Nakai Y - Search Results

1

Discovery of novel prostaglandin analogs as potent and selective EP2/EP4 dual agonists.

Kambe T, Maruyama T, Nakai Y, Yoshida H, Oida H, Maruyama T, Abe N, Nishiura A, Nakai H, Toda M. Kambe T, et al. Among authors: nakai y, nakai h. Bioorg Med Chem. 2012 Apr 1;20(7):2235-51. doi: 10.1016/j.bmc.2012.02.018. Epub 2012 Feb 16. Bioorg Med Chem. 2012. PMID: 22386979

2

Discovery of orally active prostaglandin D2 receptor antagonists.

Torisu K, Kobayashi K, Iwahashi M, Nakai Y, Onoda T, Nagase T, Sugimoto I, Okada Y, Matsumoto R, Nanbu F, Ohuchida S, Nakai H, Toda M. Torisu K, et al. Among authors: nakai y, nakai h. Bioorg Med Chem Lett. 2004 Oct 4;14(19):4891-5. doi: 10.1016/j.bmcl.2004.07.039. Bioorg Med Chem Lett. 2004. PMID: 15341946

3

Discovery of new chemical leads for prostaglandin D2 receptor antagonists.

Torisu K, Kobayashi K, Iwahashi M, Egashira H, Nakai Y, Okada Y, Nanbu F, Ohuchida S, Nakai H, Toda M. Torisu K, et al. Among authors: nakai y, nakai h. Bioorg Med Chem Lett. 2004 Sep 6;14(17):4557-62. doi: 10.1016/j.bmcl.2004.06.006. Bioorg Med Chem Lett. 2004. PMID: 15357992

4

Development of prostaglandin D2 receptor antagonist: discovery of highly potent antagonists.

Torisu K, Kobayashi K, Iwahashi M, Nakai Y, Onoda T, Nagase T, Sugimoto I, Okada Y, Matsumoto R, Nanbu F, Ohuchida S, Nakai H, Masaaki Toda. Torisu K, et al. Among authors: nakai y, nakai h. Bioorg Med Chem. 2004 Sep 1;12(17):4685-700. doi: 10.1016/j.bmc.2004.06.024. Bioorg Med Chem. 2004. PMID: 15358295

5

Discovery of a new class of potent, selective, and orally active prostaglandin D2 receptor antagonists.

Torisu K, Kobayashi K, Iwahashi M, Nakai Y, Onoda T, Nagase T, Sugimoto I, Okada Y, Matsumoto R, Nanbu F, Ohuchida S, Nakai H, Toda M. Torisu K, et al. Among authors: nakai y, nakai h. Bioorg Med Chem. 2004 Oct 15;12(20):5361-78. doi: 10.1016/j.bmc.2004.07.048. Bioorg Med Chem. 2004. PMID: 15388164

6

Development of a prostaglandin D2 receptor antagonist: discovery of a new chemical lead.

Torisu K, Kobayashi K, Iwahashi M, Egashira H, Nakai Y, Okada Y, Nanbu F, Ohuchida S, Nakai H, Toda M. Torisu K, et al. Among authors: nakai y, nakai h. Eur J Med Chem. 2005 May;40(5):505-19. doi: 10.1016/j.ejmech.2004.11.011. Eur J Med Chem. 2005. PMID: 15893024

7

3-(2-Aminocarbonylphenyl)propanoic acid analogs as potent and selective EP3 receptor antagonists. part 2: optimization of the side chains to improve in vitro and in vivo potencies.

Asada M, Iwahashi M, Obitsu T, Kinoshita A, Nakai Y, Onoda T, Nagase T, Tanaka M, Yamaura Y, Takizawa H, Yoshikawa K, Sato K, Narita M, Ohuchida S, Nakai H, Toda M. Asada M, et al. Among authors: nakai y, nakai h. Bioorg Med Chem. 2010 Feb 15;18(4):1641-58. doi: 10.1016/j.bmc.2009.12.068. Epub 2010 Jan 4. Bioorg Med Chem. 2010. PMID: 20129791

8

Discovery of novel N-acylsulfonamide analogs as potent and selective EP3 receptor antagonists.

Asada M, Obitsu T, Kinoshita A, Nakai Y, Nagase T, Sugimoto I, Tanaka M, Takizawa H, Yoshikawa K, Sato K, Narita M, Ohuchida S, Nakai H, Toda M. Asada M, et al. Among authors: nakai y, nakai h. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2639-43. doi: 10.1016/j.bmcl.2010.02.034. Epub 2010 Feb 13. Bioorg Med Chem Lett. 2010. PMID: 20346663

9

Discovery of a novel EP2/EP4 dual agonist with high subtype-selectivity.

Kambe T, Maruyama T, Nakano M, Nakai Y, Yoshida T, Matsunaga N, Oida H, Konaka A, Maruyama T, Nakai H, Toda M. Kambe T, et al. Among authors: nakai y, nakai h. Bioorg Med Chem Lett. 2012 Jan 1;22(1):396-401. doi: 10.1016/j.bmcl.2011.10.109. Epub 2011 Nov 7. Bioorg Med Chem Lett. 2012. PMID: 22119471

10

Synthesis and evaluation of γ-lactam analogs of PGE₂ as EP4 and EP2/EP4 agonists.

Kambe T, Maruyama T, Nakai Y, Oida H, Maruyama T, Abe N, Nishiura A, Nakai H, Toda M. Kambe T, et al. Among authors: nakai y, nakai h. Bioorg Med Chem. 2012 Jun 1;20(11):3502-22. doi: 10.1016/j.bmc.2012.04.008. Epub 2012 Apr 11. Bioorg Med Chem. 2012. PMID: 22546206

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