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Synthesis and optimization of novel (3S,5R)-5-(2,2-dimethyl-5-oxo-4-phenylpiperazin-1-yl)piperidine-3-carboxamides as orally active renin inhibitors.
Mori Y, Ogawa Y, Mochizuki A, Nakamura Y, Fujimoto T, Sugita C, Miyazaki S, Tamaki K, Nagayama T, Nagai Y, Inoue S, Chiba K, Nishi T. Mori Y, et al. Among authors: nakamura y. Bioorg Med Chem. 2013 Sep 15;21(18):5907-22. doi: 10.1016/j.bmc.2013.06.057. Epub 2013 Jul 2. Bioorg Med Chem. 2013. PMID: 23886807
Design and discovery of new (3S,5R)-5-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]piperidine-3-carboxamides as potent renin inhibitors.
Mori Y, Ogawa Y, Mochizuki A, Nakamura Y, Sugita C, Miyazaki S, Tamaki K, Matsui Y, Takahashi M, Nagayama T, Nagai Y, Inoue S, Nishi T. Mori Y, et al. Among authors: nakamura y. Bioorg Med Chem Lett. 2012 Dec 15;22(24):7677-82. doi: 10.1016/j.bmcl.2012.09.103. Epub 2012 Oct 17. Bioorg Med Chem Lett. 2012. PMID: 23122821
Lead optimization of 5-amino-6-(2,2-dimethyl-5-oxo-4-phenylpiperazin-1-yl)-4-hydroxyhexanamides to reduce a cardiac safety issue: discovery of DS-8108b, an orally active renin inhibitor.
Nakamura Y, Fujimoto T, Ogawa Y, Namiki H, Suzuki S, Asano M, Sugita C, Mochizuki A, Miyazaki S, Tamaki K, Nagai Y, Inoue S, Nagayama T, Kato M, Chiba K, Takasuna K, Nishi T. Nakamura Y, et al. Bioorg Med Chem. 2013 Jun 1;21(11):3175-96. doi: 10.1016/j.bmc.2013.03.022. Epub 2013 Mar 26. Bioorg Med Chem. 2013. PMID: 23598247
Discovery of DS-8108b, a Novel Orally Bioavailable Renin Inhibitor.
Nakamura Y, Fujimoto T, Ogawa Y, Sugita C, Miyazaki S, Tamaki K, Takahashi M, Matsui Y, Nagayama T, Manabe K, Mizuno M, Masubuchi N, Chiba K, Nishi T. Nakamura Y, et al. ACS Med Chem Lett. 2012 Aug 18;3(9):754-8. doi: 10.1021/ml300168e. eCollection 2012 Sep 13. ACS Med Chem Lett. 2012. PMID: 24900544 Free PMC article.
Neural-net-based cell deconvolution from DNA methylation reveals tumor microenvironment associated with cancer prognosis.
Yasumizu Y, Hagiwara M, Umezu Y, Fuji H, Iwaisako K, Asagiri M, Uemoto S, Nakamura Y, Thul S, Ueyama A, Yokoi K, Tanemura A, Nose Y, Saito T, Wada H, Kakuda M, Kohara M, Nojima S, Morii E, Doki Y, Sakaguchi S, Ohkura N. Yasumizu Y, et al. Among authors: nakamura y. NAR Cancer. 2024 May 15;6(2):zcae022. doi: 10.1093/narcan/zcae022. eCollection 2024 Jun. NAR Cancer. 2024. PMID: 38751935 Free PMC article.
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