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Page 1
The RNA-binding protein NANOS1 controls hippocampal synaptogenesis.
Maschi D, Fernández-Alvarez AJ, Boccaccio GL. Maschi D, et al. PLoS One. 2023 Apr 14;18(4):e0284589. doi: 10.1371/journal.pone.0284589. eCollection 2023. PLoS One. 2023. PMID: 37058523 Free PMC article.
In addition, Drosophila Nanos controls neuron maturation and function, and rodent Nanos1 affects cortical neuron differentiation. Here we show that rat Nanos1 is expressed in hippocampal neurons and that the siRNA-mediated knockdown of Nanos1 impairs synaptog …
In addition, Drosophila Nanos controls neuron maturation and function, and rodent Nanos1 affects cortical neuron differentiation. Her …
Pharyngeal endoderm expression of nanos1 is dispensable for craniofacial development.
Na H, Park J, Jeon H, Jin S, Choe CP. Na H, et al. Gene Expr Patterns. 2021 Sep;41:119202. doi: 10.1016/j.gep.2021.119202. Epub 2021 Aug 10. Gene Expr Patterns. 2021. PMID: 34389512
However, no craniofacial defects, such as abnormal pouches, hypoplasia of the thymus, malformed facial skeletons, have been found in nanos1 knockout animals. The normal craniofacial development of nanos1 knockout animals is unlikely a consequence of the genetic redu …
However, no craniofacial defects, such as abnormal pouches, hypoplasia of the thymus, malformed facial skeletons, have been found in nano …
Human NANOS1 Represses Apoptosis by Downregulating Pro-Apoptotic Genes in the Male Germ Cell Line.
Janecki DM, Ilaslan E, Smialek MJ, Sajek MP, Kotecki M, Ginter-Matuszewska B, Krainski P, Jaruzelska J, Kusz-Zamelczyk K. Janecki DM, et al. Int J Mol Sci. 2020 Apr 24;21(8):3009. doi: 10.3390/ijms21083009. Int J Mol Sci. 2020. PMID: 32344590 Free PMC article.
While two mouse NANOS paralogues, NANOS2 and NANOS3, are crucial for maintenance of germ cells by suppression of apoptosis, the mouse NANOS1 paralogue does not seem to regulate these processes. Previously, we described a human NANOS1 p....RNA-Seq (RNA sequencing) an …
While two mouse NANOS paralogues, NANOS2 and NANOS3, are crucial for maintenance of germ cells by suppression of apoptosis, the mouse NAN …
NANOS1 restricts oral cancer cell motility and TGF-ss signaling.
Rosemann J, Pyko J, Jacob R, Macho J, Kappler M, Eckert AW, Haemmerle M, Gutschner T. Rosemann J, et al. Eur J Cell Biol. 2024 Feb 21;103(2):151400. doi: 10.1016/j.ejcb.2024.151400. Online ahead of print. Eur J Cell Biol. 2024. PMID: 38401491 Free article.
To this end we treated oral cancer cells with TGF-ss and identified a total of 643 significantly deregulated protein-coding genes in response to TGF-ss. Of note, 19 genes encoded RBPs with NANOS1 being the most downregulated RBP. Subsequent cellular studies demonstrated a …
To this end we treated oral cancer cells with TGF-ss and identified a total of 643 significantly deregulated protein-coding genes in respons …
nanos1: a mouse nanos gene expressed in the central nervous system is dispensable for normal development.
Haraguchi S, Tsuda M, Kitajima S, Sasaoka Y, Nomura-Kitabayashid A, Kurokawa K, Saga Y. Haraguchi S, et al. Mech Dev. 2003 Jun;120(6):721-31. doi: 10.1016/s0925-4773(03)00043-1. Mech Dev. 2003. PMID: 12834871 Free article.
A mouse nanos (nanos1) gene was cloned and its function was examined by generating a gene-knockout mouse. ...The nanos1 -deficient mice develop to term without any detectable abnormality and they are fertile. ...
A mouse nanos (nanos1) gene was cloned and its function was examined by generating a gene-knockout mouse. ...The nanos1 -defic …
NANOS1 and PUMILIO2 bind microRNA biogenesis factor GEMIN3, within chromatoid body in human germ cells.
Ginter-Matuszewska B, Kusz K, Spik A, Grzeszkowiak D, Rembiszewska A, Kupryjanczyk J, Jaruzelska J. Ginter-Matuszewska B, et al. Histochem Cell Biol. 2011 Sep;136(3):279-87. doi: 10.1007/s00418-011-0842-y. Epub 2011 Jul 29. Histochem Cell Biol. 2011. PMID: 21800163
Moreover, GEMIN3 coimmunoprecipitates with NANOS1 and PUMILIO2 in transfected mammalian cells. By double immunofluorescence staining, we observed that complexes built of NANOS1, PUMILIO2 and GEMIN3 are located within cytoplasmic region of germ cells. ...NANOS1 …
Moreover, GEMIN3 coimmunoprecipitates with NANOS1 and PUMILIO2 in transfected mammalian cells. By double immunofluorescence staining, …
Distinct Roles of NANOS1 and NANOS3 in the Cell Cycle and NANOS3-PUM1-FOXM1 Axis to Control G2/M Phase in a Human Primordial Germ Cell Model.
Ilaslan E, Kwiatkowska K, Smialek MJ, Sajek MP, Lemanska Z, Alla M, Janecki DM, Jaruzelska J, Kusz-Zamelczyk K. Ilaslan E, et al. Int J Mol Sci. 2022 Jun 13;23(12):6592. doi: 10.3390/ijms23126592. Int J Mol Sci. 2022. PMID: 35743036 Free PMC article.
Our RNA-sequencing analysis in a human primordial germ cell model-TCam-2 cell line revealed distinct pools of genes involved in the cell cycle process downregulated upon NANOS1 and NANOS3 overexpression. We show that NANOS1 and NANOS3 proteins influence different st …
Our RNA-sequencing analysis in a human primordial germ cell model-TCam-2 cell line revealed distinct pools of genes involved in the cell cyc …
Nanos1 functions as a translational repressor in the Xenopus germline.
Lai F, Zhou Y, Luo X, Fox J, King ML. Lai F, et al. Mech Dev. 2011 Jan-Feb;128(1-2):153-63. doi: 10.1016/j.mod.2010.12.001. Epub 2010 Dec 30. Mech Dev. 2011. PMID: 21195170 Free PMC article.
Although Nanos1 can repress capped and polyadenylated RNAs, Nanos1 mediated repression did not require the targeted RNA to have a cap or to be polyadenylated. These results suggest that Nanos1 is capable of repressing translation by several different mechanis …
Although Nanos1 can repress capped and polyadenylated RNAs, Nanos1 mediated repression did not require the targeted RNA to hav …
Xenopus germline nanos1 is translationally repressed by a novel structure-based mechanism.
Luo X, Nerlick S, An W, King ML. Luo X, et al. Development. 2011 Feb;138(3):589-98. doi: 10.1242/dev.056705. Development. 2011. PMID: 21205802 Free PMC article.
Surprisingly, we observed that unlike other mRNAs, synthetic nanos1 RNA translates very poorly if at all after injection into Xenopus oocytes. ...Misexpression of Nanos1 in oocytes from unlocalized RNA results in abnormal development, highlighting the importance of …
Surprisingly, we observed that unlike other mRNAs, synthetic nanos1 RNA translates very poorly if at all after injection into Xenopus …
100 results