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Page 1
The Role of NCOA4-Mediated Ferritinophagy in Ferroptosis.
Santana-Codina N, Gikandi A, Mancias JD. Santana-Codina N, et al. Adv Exp Med Biol. 2021;1301:41-57. doi: 10.1007/978-3-030-62026-4_4. Adv Exp Med Biol. 2021. PMID: 34370287 Review.
Nuclear receptor coactivator 4 (NCOA4) is a selective cargo receptor that mediates the autophagic degradation of ferritin, the cytosolic iron storage complex, in a process known as ferritinophagy. NCOA4-mediated ferritinophagy is required to maintain intracellular a …
Nuclear receptor coactivator 4 (NCOA4) is a selective cargo receptor that mediates the autophagic degradation of ferritin, the cytoso …
ATM orchestrates ferritinophagy and ferroptosis by phosphorylating NCOA4.
Wu H, Liu Q, Shan X, Gao W, Chen Q. Wu H, et al. Autophagy. 2023 Jul;19(7):2062-2077. doi: 10.1080/15548627.2023.2170960. Epub 2023 Feb 8. Autophagy. 2023. PMID: 36752571 Free PMC article.
Mechanistically, ATM dominates the intracellular labile free iron by phosphorylating NCOA4, facilitating NCOA4-ferritin interaction and therefore sustaining ferritinophagy, a selective type of macroautophagy/autophagy specifically degrading ferritin for iron recycli …
Mechanistically, ATM dominates the intracellular labile free iron by phosphorylating NCOA4, facilitating NCOA4-ferritin intera …
Inhibiting Ferroptosis through Disrupting the NCOA4-FTH1 Interaction: A New Mechanism of Action.
Fang Y, Chen X, Tan Q, Zhou H, Xu J, Gu Q. Fang Y, et al. ACS Cent Sci. 2021 Jun 23;7(6):980-989. doi: 10.1021/acscentsci.0c01592. Epub 2021 May 6. ACS Cent Sci. 2021. PMID: 34235259 Free PMC article.
Compound 9a blocks ferroptosis by reducing the amount of bioavailable intracellular ferrous iron through disrupting the NCOA4-FTH1 protein-protein interaction. Further studies indicate that 9a directly binds to recombinant protein NCOA4(383-522) and effectively bloc …
Compound 9a blocks ferroptosis by reducing the amount of bioavailable intracellular ferrous iron through disrupting the NCOA4-FTH1 pr …
The Role of NCOA4-Mediated Ferritinophagy in Health and Disease.
Santana-Codina N, Mancias JD. Santana-Codina N, et al. Pharmaceuticals (Basel). 2018 Oct 23;11(4):114. doi: 10.3390/ph11040114. Pharmaceuticals (Basel). 2018. PMID: 30360520 Free PMC article. Review.
Nuclear receptor coactivator 4 (NCOA4) is a selective cargo receptor that mediates the autophagic degradation of ferritin ("ferritinophagy"), the cytosolic iron storage complex. NCOA4-mediated ferritinophagy maintains intracellular iron homeostasis by facilitating f …
Nuclear receptor coactivator 4 (NCOA4) is a selective cargo receptor that mediates the autophagic degradation of ferritin ("ferritino …
The interaction between STING and NCOA4 exacerbates lethal sepsis by orchestrating ferroptosis and inflammatory responses in macrophages.
Wu J, Liu Q, Zhang X, Tan M, Li X, Liu P, Wu L, Jiao F, Lin Z, Wu X, Wang X, Zhao Y, Ren J. Wu J, et al. Cell Death Dis. 2022 Jul 28;13(7):653. doi: 10.1038/s41419-022-05115-x. Cell Death Dis. 2022. PMID: 35902564 Free PMC article.
Mechanistically, Q237, E316, and S322 in the CBD domain of STING are critical binding sites for the interaction with the coiled-coil domain of NCOA4. Their interaction not only triggers ferritinophagy-mediated ferroptosis, but also maintains the stability of STING dimers l …
Mechanistically, Q237, E316, and S322 in the CBD domain of STING are critical binding sites for the interaction with the coiled-coil domain …
NCOA4-mediated ferritinophagy is involved in ionizing radiation-induced ferroptosis of intestinal epithelial cells.
Zhou H, Zhou YL, Mao JA, Tang LF, Xu J, Wang ZX, He Y, Li M. Zhou H, et al. Redox Biol. 2022 Sep;55:102413. doi: 10.1016/j.redox.2022.102413. Epub 2022 Jul 30. Redox Biol. 2022. PMID: 35932693 Free PMC article.
Intriguingly, pharmacological inhibition of autophagy with 3-methyladenine (3-MA) mitigated IR-induced ferritin downregulation, iron overload and ferroptosis. IR increased the levels of nuclear receptor coactivator 4 (NCOA4) mRNA and protein. NCOA4 knockdown signifi …
Intriguingly, pharmacological inhibition of autophagy with 3-methyladenine (3-MA) mitigated IR-induced ferritin downregulation, iron overloa …
TRIM7 modulates NCOA4-mediated ferritinophagy and ferroptosis in glioblastoma cells.
Li K, Chen B, Xu A, Shen J, Li K, Hao K, Hao R, Yang W, Jiang W, Zheng Y, Ge F, Wang Z. Li K, et al. Redox Biol. 2022 Oct;56:102451. doi: 10.1016/j.redox.2022.102451. Epub 2022 Aug 28. Redox Biol. 2022. PMID: 36067704 Free PMC article.
Mechanistically, TRIM7 directly bound to and ubiquitinated nuclear receptor coactivator 4 (NCOA4) using K48-linked chains, thereby reducing NCOA4-mediated ferritinophagy and ferroptosis of human glioblastoma cells. ...CONCLUSION: We for the first time demonstrate th …
Mechanistically, TRIM7 directly bound to and ubiquitinated nuclear receptor coactivator 4 (NCOA4) using K48-linked chains, thereby re …
Mycobacterium tuberculosis hijacks host TRIM21- and NCOA4-dependent ferritinophagy to enhance intracellular growth.
Dai Y, Zhu C, Xiao W, Huang K, Wang X, Shi C, Lin D, Zhang H, Liu X, Peng B, Gao Y, Liu CH, Ge B, Kaufmann SH, Feng CG, Chen X, Cai Y. Dai Y, et al. J Clin Invest. 2023 Apr 17;133(8):e159941. doi: 10.1172/JCI159941. J Clin Invest. 2023. PMID: 37066876 Free PMC article.
Of clinical relevance, the upregulation of FTH1 in macrophages was associated with tuberculosis (TB) disease progression in humans. Mechanistically, Mtb infection enhanced NCOA4-mediated ferritin degradation through p38/AKT1- and TRIM21-mediated proteasomal degradation of …
Of clinical relevance, the upregulation of FTH1 in macrophages was associated with tuberculosis (TB) disease progression in humans. Mechanis …
NCOA4 drives ferritin phase separation to facilitate macroferritinophagy and microferritinophagy.
Ohshima T, Yamamoto H, Sakamaki Y, Saito C, Mizushima N. Ohshima T, et al. J Cell Biol. 2022 Oct 3;221(10):e202203102. doi: 10.1083/jcb.202203102. Epub 2022 Sep 6. J Cell Biol. 2022. PMID: 36066504 Free PMC article.
However, it is unclear whether NCOA4 only acts as an autophagy receptor in ferritin degradation. Here, we found that ferritin particles form liquid-like condensates in a NCOA4-dependent manner. Homodimerization of NCOA4 and interaction between FTH1 and NCO …
However, it is unclear whether NCOA4 only acts as an autophagy receptor in ferritin degradation. Here, we found that ferritin particl …
Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy.
Mancias JD, Wang X, Gygi SP, Harper JW, Kimmelman AC. Mancias JD, et al. Nature. 2014 May 1;509(7498):105-9. doi: 10.1038/nature13148. Epub 2014 Mar 30. Nature. 2014. PMID: 24695223 Free PMC article.
We found that delivery of ferritin to lysosomes required NCOA4, and an inability of NCOA4-deficient cells to degrade ferritin led to decreased bioavailable intracellular iron. This work identifies NCOA4 as a selective cargo receptor for autophagic turnover of …
We found that delivery of ferritin to lysosomes required NCOA4, and an inability of NCOA4-deficient cells to degrade ferritin …
588 results