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Deep sequencing of proteotoxicity modifier genes uncovers a Presenilin-2/beta-amyloid-actin genetic risk module shared among alpha-synucleinopathies.
Nazeen S, Wang X, Zielinski D, Lam I, Hallacli E, Xu P, Ethier E, Strom R, Zanella CA, Nithianandam V, Ritter D, Henderson A, Saurat N, Afroz J, Nutter-Upham A, Benyamini H, Copty J, Ravishankar S, Morrow A, Mitchel J, Neavin D, Gupta R, Farbehi N, Grundman J, Myers RH, Scherzer CR, Trojanowski JQ, Van Deerlin VM, Cooper AA, Lee EB, Erlich Y, Lindquist S, Peng J, Geschwind DH, Powell J, Studer L, Feany MB, Sunyaev SR, Khurana V. Nazeen S, et al. Among authors: neavin d. bioRxiv [Preprint]. 2024 Mar 7:2024.03.03.583145. doi: 10.1101/2024.03.03.583145. bioRxiv. 2024. PMID: 38496508 Free PMC article. Preprint.
Molecular profiling of human substantia nigra identifies diverse neuron types associated with vulnerability in Parkinson's disease.
Wang Q, Wang M, Choi I, Sarrafha L, Liang M, Ho L, Farrell K, Beaumont KG, Sebra R, De Sanctis C, Crary JF, Ahfeldt T, Blanchard J, Neavin D, Powell J, Davis DA, Sun X, Zhang B, Yue Z. Wang Q, et al. Among authors: neavin d. Sci Adv. 2024 Jan 12;10(2):eadi8287. doi: 10.1126/sciadv.adi8287. Epub 2024 Jan 10. Sci Adv. 2024. PMID: 38198537 Free PMC article.
Novel human pluripotent stem cell-derived hypothalamus organoids demonstrate cellular diversity.
Sarrafha L, Neavin DR, Parfitt GM, Kruglikov IA, Whitney K, Reyes R, Coccia E, Kareva T, Goldman C, Tipon R, Croft G, Crary JF, Powell JE, Blanchard J, Ahfeldt T. Sarrafha L, et al. Among authors: neavin dr. iScience. 2023 Aug 2;26(9):107525. doi: 10.1016/j.isci.2023.107525. eCollection 2023 Sep 15. iScience. 2023. PMID: 37646018 Free PMC article.
A village in a dish model system for population-scale hiPSC studies.
Neavin DR, Steinmann AM, Farbehi N, Chiu HS, Daniszewski MS, Arora H, Bermudez Y, Moutinho C, Chan CL, Bax M, Tyebally M, Gnanasambandapillai V, Lam CE, Nguyen U, Hernández D, Lidgerwood GE, Graham RM, Hewitt AW, Pébay A, Palpant NJ, Powell JE. Neavin DR, et al. Nat Commun. 2023 Jun 9;14(1):3240. doi: 10.1038/s41467-023-38704-1. Nat Commun. 2023. PMID: 37296104 Free PMC article.
Transcriptomic and proteomic retinal pigment epithelium signatures of age-related macular degeneration.
Senabouth A, Daniszewski M, Lidgerwood GE, Liang HH, Hernández D, Mirzaei M, Keenan SN, Zhang R, Han X, Neavin D, Rooney L, Lopez Sanchez MIG, Gulluyan L, Paulo JA, Clarke L, Kearns LS, Gnanasambandapillai V, Chan CL, Nguyen U, Steinmann AM, McCloy RA, Farbehi N, Gupta VK, Mackey DA, Bylsma G, Verma N, MacGregor S, Watt MJ, Guymer RH, Powell JE, Hewitt AW, Pébay A. Senabouth A, et al. Among authors: neavin d. Nat Commun. 2022 Jul 26;13(1):4233. doi: 10.1038/s41467-022-31707-4. Nat Commun. 2022. PMID: 35882847 Free PMC article.
Single cell eQTL analysis identifies cell type-specific genetic control of gene expression in fibroblasts and reprogrammed induced pluripotent stem cells.
Neavin D, Nguyen Q, Daniszewski MS, Liang HH, Chiu HS, Wee YK, Senabouth A, Lukowski SW, Crombie DE, Lidgerwood GE, Hernández D, Vickers JC, Cook AL, Palpant NJ, Pébay A, Hewitt AW, Powell JE. Neavin D, et al. Genome Biol. 2021 Mar 5;22(1):76. doi: 10.1186/s13059-021-02293-3. Genome Biol. 2021. PMID: 33673841 Free PMC article.
25 results