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Sox5 regulates beta-cell phenotype and is reduced in type 2 diabetes.
Axelsson AS, Mahdi T, Nenonen HA, Singh T, Hänzelmann S, Wendt A, Bagge A, Reinbothe TM, Millstein J, Yang X, Zhang B, Gusmao EG, Shu L, Szabat M, Tang Y, Wang J, Salö S, Eliasson L, Artner I, Fex M, Johnson JD, Wollheim CB, Derry JMJ, Mecham B, Spégel P, Mulder H, Costa IG, Zhang E, Rosengren AH. Axelsson AS, et al. Among authors: nenonen ha. Nat Commun. 2017 Jun 6;8:15652. doi: 10.1038/ncomms15652. Nat Commun. 2017. PMID: 28585545 Free PMC article.
Thrombin stimulates insulin secretion via protease-activated receptor-3.
Hänzelmann S, Wang J, Güney E, Tang Y, Zhang E, Axelsson AS, Nenonen H, Salehi AS, Wollheim CB, Zetterberg E, Berntorp E, Costa IG, Castelo R, Rosengren AH. Hänzelmann S, et al. Islets. 2015;7(4):e1118195. doi: 10.1080/19382014.2015.1118195. Islets. 2015. PMID: 26742564 Free PMC article.