Nes WD - Search Results

1

CYP51 from Trypanosoma brucei is obtusifoliol-specific.

Lepesheva GI, Nes WD, Zhou W, Hill GC, Waterman MR. Lepesheva GI, et al. Among authors: nes wd. Biochemistry. 2004 Aug 24;43(33):10789-99. doi: 10.1021/bi048967t. Biochemistry. 2004. PMID: 15311940

2

CYP51 from Trypanosoma cruzi: a phyla-specific residue in the B' helix defines substrate preferences of sterol 14alpha-demethylase.

Lepesheva GI, Zaitseva NG, Nes WD, Zhou W, Arase M, Liu J, Hill GC, Waterman MR. Lepesheva GI, et al. Among authors: nes wd. J Biol Chem. 2006 Feb 10;281(6):3577-85. doi: 10.1074/jbc.M510317200. Epub 2005 Nov 30. J Biol Chem. 2006. PMID: 16321980 Free article.

3

Mechanistic analysis of a multiple product sterol methyltransferase implicated in ergosterol biosynthesis in Trypanosoma brucei.

Zhou W, Lepesheva GI, Waterman MR, Nes WD. Zhou W, et al. Among authors: nes wd. J Biol Chem. 2006 Mar 10;281(10):6290-6. doi: 10.1074/jbc.M511749200. Epub 2006 Jan 12. J Biol Chem. 2006. PMID: 16414960 Free article.

4

Sterol 14alpha-demethylase as a potential target for antitrypanosomal therapy: enzyme inhibition and parasite cell growth.

Lepesheva GI, Ott RD, Hargrove TY, Kleshchenko YY, Schuster I, Nes WD, Hill GC, Villalta F, Waterman MR. Lepesheva GI, et al. Among authors: nes wd. Chem Biol. 2007 Nov;14(11):1283-93. doi: 10.1016/j.chembiol.2007.10.011. Chem Biol. 2007. PMID: 18022567 Free PMC article.

5

CYP51: A major drug target in the cytochrome P450 superfamily.

Lepesheva GI, Hargrove TY, Kleshchenko Y, Nes WD, Villalta F, Waterman MR. Lepesheva GI, et al. Among authors: nes wd. Lipids. 2008 Dec;43(12):1117-25. doi: 10.1007/s11745-008-3225-y. Epub 2008 Sep 4. Lipids. 2008. PMID: 18769951 Free PMC article.

6

Indomethacin amides as a novel molecular scaffold for targeting Trypanosoma cruzi sterol 14alpha-demethylase.

Konkle ME, Hargrove TY, Kleshchenko YY, von Kries JP, Ridenour W, Uddin MJ, Caprioli RM, Marnett LJ, Nes WD, Villalta F, Waterman MR, Lepesheva GI. Konkle ME, et al. Among authors: nes wd. J Med Chem. 2009 May 14;52(9):2846-53. doi: 10.1021/jm801643b. J Med Chem. 2009. PMID: 19354253 Free PMC article.

7

Crystal structures of Trypanosoma brucei sterol 14alpha-demethylase and implications for selective treatment of human infections.

Lepesheva GI, Park HW, Hargrove TY, Vanhollebeke B, Wawrzak Z, Harp JM, Sundaramoorthy M, Nes WD, Pays E, Chaudhuri M, Villalta F, Waterman MR. Lepesheva GI, et al. Among authors: nes wd. J Biol Chem. 2010 Jan 15;285(3):1773-80. doi: 10.1074/jbc.M109.067470. Epub 2009 Nov 18. J Biol Chem. 2010. PMID: 19923211 Free PMC article.

8

Substrate preferences and catalytic parameters determined by structural characteristics of sterol 14alpha-demethylase (CYP51) from Leishmania infantum.

Hargrove TY, Wawrzak Z, Liu J, Nes WD, Waterman MR, Lepesheva GI. Hargrove TY, et al. Among authors: nes wd. J Biol Chem. 2011 Jul 29;286(30):26838-48. doi: 10.1074/jbc.M111.237099. Epub 2011 May 31. J Biol Chem. 2011. PMID: 21632531 Free PMC article.

9

Structural complex of sterol 14α-demethylase (CYP51) with 14α-methylenecyclopropyl-Delta7-24, 25-dihydrolanosterol.

Hargrove TY, Wawrzak Z, Liu J, Waterman MR, Nes WD, Lepesheva GI. Hargrove TY, et al. Among authors: nes wd. J Lipid Res. 2012 Feb;53(2):311-20. doi: 10.1194/jlr.M021865. Epub 2011 Nov 30. J Lipid Res. 2012. PMID: 22135275 Free PMC article.

10

Biodiversity of CYP51 in trypanosomes.

Lepesheva GI, Hargrove TY, Ott RD, Nes WD, Waterman MR. Lepesheva GI, et al. Among authors: nes wd. Biochem Soc Trans. 2006 Dec;34(Pt 6):1161-4. doi: 10.1042/BST0341161. Biochem Soc Trans. 2006. PMID: 17073776

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