Nesi G - Search Results

1

SAR study on arylmethyloxyphenyl scaffold: looking for a P-gp nanomolar affinity.

Nesi G, Colabufo NA, Contino M, Perrone MG, Digiacomo M, Perrone R, Lapucci A, Macchia M, Rapposelli S. Nesi G, et al. Eur J Med Chem. 2014 Apr 9;76:558-66. doi: 10.1016/j.ejmech.2014.02.051. Epub 2014 Feb 21. Eur J Med Chem. 2014. PMID: 24607999

2

Design and synthesis of 2-oxindole based multi-targeted inhibitors of PDK1/Akt signaling pathway for the treatment of glioblastoma multiforme.

Sestito S, Nesi G, Daniele S, Martelli A, Digiacomo M, Borghini A, Pietra D, Calderone V, Lapucci A, Falasca M, Parrella P, Notarangelo A, Breschi MC, Macchia M, Martini C, Rapposelli S. Sestito S, et al. Among authors: nesi g. Eur J Med Chem. 2015 Nov 13;105:274-88. doi: 10.1016/j.ejmech.2015.10.020. Epub 2015 Oct 22. Eur J Med Chem. 2015. PMID: 26498573

3

Locking PDK1 in DFG-out conformation through 2-oxo-indole containing molecules: Another tools to fight glioblastoma.

Sestito S, Daniele S, Nesi G, Zappelli E, Di Maio D, Marinelli L, Digiacomo M, Lapucci A, Martini C, Novellino E, Rapposelli S. Sestito S, et al. Among authors: nesi g. Eur J Med Chem. 2016 Aug 8;118:47-63. doi: 10.1016/j.ejmech.2016.04.003. Epub 2016 Apr 20. Eur J Med Chem. 2016. PMID: 27123901

4

Discovery of novel rivastigmine-hydroxycinnamic acid hybrids as multi-targeted agents for Alzheimer's disease.

Chen Z, Digiacomo M, Tu Y, Gu Q, Wang S, Yang X, Chu J, Chen Q, Han Y, Chen J, Nesi G, Sestito S, Macchia M, Rapposelli S, Pi R. Chen Z, et al. Among authors: nesi g. Eur J Med Chem. 2017 Jan 5;125:784-792. doi: 10.1016/j.ejmech.2016.09.052. Epub 2016 Sep 17. Eur J Med Chem. 2017. PMID: 27736684

5

Design, Synthesis, and Evaluation of Thyronamine Analogues as Novel Potent Mouse Trace Amine Associated Receptor 1 (mTAAR1) Agonists.

Chiellini G, Nesi G, Digiacomo M, Malvasi R, Espinoza S, Sabatini M, Frascarelli S, Laurino A, Cichero E, Macchia M, Gainetdinov RR, Fossa P, Raimondi L, Zucchi R, Rapposelli S. Chiellini G, et al. Among authors: nesi g. J Med Chem. 2015 Jun 25;58(12):5096-107. doi: 10.1021/acs.jmedchem.5b00526. Epub 2015 Jun 5. J Med Chem. 2015. PMID: 26010728

6

Synthesis and In Vivo Imaging of N-(3-[¹¹C]Methoxybenzyl)-2-(3-Methoxyphenyl)ethylaniline as a Potential Targeting Agent for P-glycoprotein.

Petroni D, Bartoli A, Rapposelli S, Digiacomo M, Burchielli S, Nesi G, Lapucci A, Pardini S, Fucci S, Macchia M, Salvadori PA, Menichetti L. Petroni D, et al. Among authors: nesi g. Mol Imaging Biol. 2016 Dec;18(6):916-923. doi: 10.1007/s11307-016-0965-6. Mol Imaging Biol. 2016. PMID: 27234445

7

Synthesis and Functional Evaluation of Novel Aldose Reductase Inhibitors Bearing a Spirobenzopyran Scaffold.

Digiacomo M, Sartini S, Nesi G, Sestito S, Coviello V, La Motta C, Rapposelli S. Digiacomo M, et al. Among authors: nesi g. Open Med Chem J. 2017 Jan 31;11:9-23. doi: 10.2174/1874104501711010009. eCollection 2017. Open Med Chem J. 2017. PMID: 28567125 Free PMC article.

8

Oxidative Stress, Mitochondrial Abnormalities and Proteins Deposition: Multitarget Approaches in Alzheimer's Disease.

Nesi G, Sestito S, Digiacomo M, Rapposelli S. Nesi G, et al. Curr Top Med Chem. 2017;17(27):3062-3079. doi: 10.2174/1568026617666170607114232. Curr Top Med Chem. 2017. PMID: 28595557 Review.

9

Iminothioethers as Hydrogen Sulfide Donors: From the Gasotransmitter Release to the Vascular Effects.

Barresi E, Nesi G, Citi V, Piragine E, Piano I, Taliani S, Da Settimo F, Rapposelli S, Testai L, Breschi MC, Gargini C, Calderone V, Martelli A. Barresi E, et al. Among authors: nesi g. J Med Chem. 2017 Sep 14;60(17):7512-7523. doi: 10.1021/acs.jmedchem.7b00888. Epub 2017 Aug 25. J Med Chem. 2017. PMID: 28799763

10

Nature-based molecules combined with rivastigmine: A symbiotic approach for the synthesis of new agents against Alzheimer's disease.

Nesi G, Chen Q, Sestito S, Digiacomo M, Yang X, Wang S, Pi R, Rapposelli S. Nesi G, et al. Eur J Med Chem. 2017 Dec 1;141:232-239. doi: 10.1016/j.ejmech.2017.10.006. Epub 2017 Oct 4. Eur J Med Chem. 2017. PMID: 29031070

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