Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1993 2
1996 1
1997 5
1998 3
1999 10
2000 17
2001 12
2002 23
2003 19
2004 23
2005 27
2006 29
2007 32
2008 34
2009 33
2010 45
2011 55
2012 51
2013 53
2014 61
2015 54
2016 56
2017 68
2018 55
2019 69
2020 79
2021 94
2022 105
2023 90
2024 42

Text availability

Article attribute

Article type

Publication date

Search Results

1,102 results

Results by year

Filters applied: . Clear all
Page 1
NeuroD1 induces microglial apoptosis and cannot induce microglia-to-neuron cross-lineage reprogramming.
Rao Y, Du S, Yang B, Wang Y, Li Y, Li R, Zhou T, Du X, He Y, Wang Y, Zhou X, Yuan TF, Mao Y, Peng B. Rao Y, et al. Neuron. 2021 Dec 15;109(24):4094-4108.e5. doi: 10.1016/j.neuron.2021.11.008. Epub 2021 Dec 6. Neuron. 2021. PMID: 34875233 Free article.
However, the extent to which NeuroD1 can exert cross-lineage reprogramming of microglia (myeloid lineage) to neurons (neuroectodermal lineage) is unclear. In this study, we unexpectedly found that NeuroD1 cannot convert microglia to neurons in mice. Instead, Neur …
However, the extent to which NeuroD1 can exert cross-lineage reprogramming of microglia (myeloid lineage) to neurons (neuroectodermal …
SCLC Subtypes Defined by ASCL1, NEUROD1, POU2F3, and YAP1: A Comprehensive Immunohistochemical and Histopathologic Characterization.
Baine MK, Hsieh MS, Lai WV, Egger JV, Jungbluth AA, Daneshbod Y, Beras A, Spencer R, Lopardo J, Bodd F, Montecalvo J, Sauter JL, Chang JC, Buonocore DJ, Travis WD, Sen T, Poirier JT, Rudin CM, Rekhtman N. Baine MK, et al. J Thorac Oncol. 2020 Dec;15(12):1823-1835. doi: 10.1016/j.jtho.2020.09.009. Epub 2020 Oct 1. J Thorac Oncol. 2020. PMID: 33011388 Free PMC article.
Subtypes defined by these markers were correlated with histologic characteristics, expression of classic neuroendocrine markers (synaptophysin, chromogranin A, CD56, INSM1), and other SCLC markers, including the neuroendocrine phenotype-associated markers TTF-1 and DLL3. RESULTS: …
Subtypes defined by these markers were correlated with histologic characteristics, expression of classic neuroendocrine markers (synaptophys …
ASCL1 and NEUROD1 Reveal Heterogeneity in Pulmonary Neuroendocrine Tumors and Regulate Distinct Genetic Programs.
Borromeo MD, Savage TK, Kollipara RK, He M, Augustyn A, Osborne JK, Girard L, Minna JD, Gazdar AF, Cobb MH, Johnson JE. Borromeo MD, et al. Cell Rep. 2016 Aug 2;16(5):1259-1272. doi: 10.1016/j.celrep.2016.06.081. Epub 2016 Jul 21. Cell Rep. 2016. PMID: 27452466 Free PMC article.
Here, we find that ASCL1 and NEUROD1 identify heterogeneity in SCLC, bind distinct genomic loci, and regulate mostly distinct genes. ...ASCL1 targets oncogenic genes including MYCL1, RET, SOX2, and NFIB while NEUROD1 targets MYC. ASCL1 and NEUROD1 regulate di …
Here, we find that ASCL1 and NEUROD1 identify heterogeneity in SCLC, bind distinct genomic loci, and regulate mostly distinct genes. …
Pioneer Factor NeuroD1 Rearranges Transcriptional and Epigenetic Profiles to Execute Microglia-Neuron Conversion.
Matsuda T, Irie T, Katsurabayashi S, Hayashi Y, Nagai T, Hamazaki N, Adefuin AMD, Miura F, Ito T, Kimura H, Shirahige K, Takeda T, Iwasaki K, Imamura T, Nakashima K. Matsuda T, et al. Neuron. 2019 Feb 6;101(3):472-485.e7. doi: 10.1016/j.neuron.2018.12.010. Epub 2019 Jan 9. Neuron. 2019. PMID: 30638745 Free article.
Exogenous NeuroD1 initially occupies closed chromatin regions associated with bivalent trimethylation of histone H3 at lysine 4 (H3K4me3) and H3K27me3 marks in microglia to induce neuronal gene expression. ...Furthermore, the transcriptional repressors Scrt1 and Meis2 are …
Exogenous NeuroD1 initially occupies closed chromatin regions associated with bivalent trimethylation of histone H3 at lysine 4 (H3K4 …
A NeuroD1 AAV-Based Gene Therapy for Functional Brain Repair after Ischemic Injury through In Vivo Astrocyte-to-Neuron Conversion.
Chen YC, Ma NX, Pei ZF, Wu Z, Do-Monte FH, Keefe S, Yellin E, Chen MS, Yin JC, Lee G, Minier-Toribio A, Hu Y, Bai YT, Lee K, Quirk GJ, Chen G. Chen YC, et al. Mol Ther. 2020 Jan 8;28(1):217-234. doi: 10.1016/j.ymthe.2019.09.003. Epub 2019 Sep 6. Mol Ther. 2020. PMID: 31551137 Free PMC article.
Specifically, using NeuroD1 adeno-associated virus (AAV)-based gene therapy, we were able to regenerate one third of the total lost neurons caused by ischemic injury and simultaneously protect another one third of injured neurons, leading to a significant neuronal recovery …
Specifically, using NeuroD1 adeno-associated virus (AAV)-based gene therapy, we were able to regenerate one third of the total lost n …
NeuroD1 administration ameliorated neuroinflammation and boosted neurogenesis in a mouse model of subarachnoid hemorrhage.
Chen P, Liu XY, Lin MH, Li YX, Kang DZ, Ye ZC, Lin QS. Chen P, et al. J Neuroinflammation. 2023 Nov 12;20(1):261. doi: 10.1186/s12974-023-02949-w. J Neuroinflammation. 2023. PMID: 37953259 Free PMC article.
SAH was established by pre-chiasmatic injection of 100 mul blood. AAV-NeuroD1-GFP virus was injected to the hippocampus 3 day post-SAH. ...Functionally, NeuroD1 treatment significantly alleviated neurocognitive dysfunction impaired by SAH. ...
SAH was established by pre-chiasmatic injection of 100 mul blood. AAV-NeuroD1-GFP virus was injected to the hippocampus 3 day post-SA …
Neurog1, Neurod1, and Atoh1 are essential for spiral ganglia, cochlear nuclei, and cochlear hair cell development.
Elliott KL, Pavlinkova G, Chizhikov VV, Yamoah EN, Fritzsch B. Elliott KL, et al. Fac Rev. 2021 May 11;10:47. doi: 10.12703/r/10-47. eCollection 2021. Fac Rev. 2021. PMID: 34131657 Free PMC article. Review.
Neuronal development requires early expression of Neurog1, followed by its downstream target Neurod1, which downregulates Atoh1 expression. In contrast, hair cells and cochlear nuclei critically depend on Atoh1 and require Neurod1 and Neurog1 expression for various …
Neuronal development requires early expression of Neurog1, followed by its downstream target Neurod1, which downregulates Atoh1 expre …
NeuroD1-GPX4 signaling leads to ferroptosis resistance in hepatocellular carcinoma.
Huang P, Duan W, Ruan C, Wang L, Hosea R, Wu Z, Zeng J, Wu S, Kasim V. Huang P, et al. PLoS Genet. 2023 Dec 22;19(12):e1011098. doi: 10.1371/journal.pgen.1011098. eCollection 2023 Dec. PLoS Genet. 2023. PMID: 38134213 Free PMC article.
These findings not only identify NeuroD1 as a regulator of tumor cell ferroptosis resistance but also reveal a novel molecular mechanism underlying the oncogenic function of NeuroD1. Furthermore, our findings suggest the potential of targeting NeuroD1 in anti …
These findings not only identify NeuroD1 as a regulator of tumor cell ferroptosis resistance but also reveal a novel molecular mechan …
Genetic Dissection and Clinical Features of MODY6 (NEUROD1-MODY).
Horikawa Y, Enya M. Horikawa Y, et al. Curr Diab Rep. 2019 Feb 22;19(3):12. doi: 10.1007/s11892-019-1130-9. Curr Diab Rep. 2019. PMID: 30793219 Review.
PURPOSE OF REVIEW: MODY6 due to mutations in the gene NEUROD1 is very rare, and details on its clinical manifestation and pathogenesis are scarce. ...
PURPOSE OF REVIEW: MODY6 due to mutations in the gene NEUROD1 is very rare, and details on its clinical manifestation and pathogenesi …
NEUROD1 reinforces endocrine cell fate acquisition in pancreatic development.
Bohuslavova R, Fabriciova V, Smolik O, Lebrón-Mora L, Abaffy P, Benesova S, Zucha D, Valihrach L, Berkova Z, Saudek F, Pavlinkova G. Bohuslavova R, et al. Nat Commun. 2023 Sep 9;14(1):5554. doi: 10.1038/s41467-023-41306-6. Nat Commun. 2023. PMID: 37689751 Free PMC article.
NEUROD1 is a transcription factor that helps maintain a mature phenotype of pancreatic beta cells. Disruption of Neurod1 during pancreatic development causes severe neonatal diabetes; however, the exact role of NEUROD1 in the differentiation programs of endoc …
NEUROD1 is a transcription factor that helps maintain a mature phenotype of pancreatic beta cells. Disruption of Neurod1 durin …
1,102 results