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Identifying dominant-negative actions of a dopamine transporter variant in patients with parkinsonism and neuropsychiatric disease.
Herborg F, Jensen KL, Tolstoy S, Arends NV, Posselt LP, Shekar A, Aguilar JI, Lund VK, Erreger K, Rickhag M, Lycas MD, Lonsdale MN, Rahbek-Clemmensen T, Sørensen AT, Newman AH, Løkkegaard A, Kjærulff O, Werge T; iPSYCH researchers; Møller LB, Matthies HJ, Galli A, Hjermind LE, Gether U. Herborg F, et al. Among authors: newman ah. JCI Insight. 2021 Sep 22;6(18):e151496. doi: 10.1172/jci.insight.151496. JCI Insight. 2021. PMID: 34375312 Free PMC article.
The N terminus of monoamine transporters is a lever required for the action of amphetamines.
Sucic S, Dallinger S, Zdrazil B, Weissensteiner R, Jørgensen TN, Holy M, Kudlacek O, Seidel S, Cha JH, Gether U, Newman AH, Ecker GF, Freissmuth M, Sitte HH. Sucic S, et al. Among authors: newman ah. J Biol Chem. 2010 Apr 2;285(14):10924-38. doi: 10.1074/jbc.M109.083154. Epub 2010 Jan 29. J Biol Chem. 2010. PMID: 20118234 Free PMC article.
A C-terminal PDZ domain-binding sequence is required for striatal distribution of the dopamine transporter.
Rickhag M, Hansen FH, Sørensen G, Strandfelt KN, Andresen B, Gotfryd K, Madsen KL, Vestergaard-Klewe I, Ammendrup-Johnsen I, Eriksen J, Newman AH, Füchtbauer EM, Gomeza J, Woldbye DP, Wörtwein G, Gether U. Rickhag M, et al. Among authors: newman ah. Nat Commun. 2013;4:1580. doi: 10.1038/ncomms2568. Nat Commun. 2013. PMID: 23481388 Free PMC article.
Missense dopamine transporter mutations associate with adult parkinsonism and ADHD.
Hansen FH, Skjørringe T, Yasmeen S, Arends NV, Sahai MA, Erreger K, Andreassen TF, Holy M, Hamilton PJ, Neergheen V, Karlsborg M, Newman AH, Pope S, Heales SJ, Friberg L, Law I, Pinborg LH, Sitte HH, Loland C, Shi L, Weinstein H, Galli A, Hjermind LE, Møller LB, Gether U. Hansen FH, et al. Among authors: newman ah. J Clin Invest. 2014 Jul;124(7):3107-20. doi: 10.1172/JCI73778. Epub 2014 Jun 9. J Clin Invest. 2014. PMID: 24911152 Free PMC article.
Empowering Voices: Inspiring Women in Medicinal Chemistry.
Blanco MJ, Bronson JJ, DiMauro EF, Dzierba C, Eggen M, Garner AL, Georg G, Giarolla J, Goodwin NC, Grenier-Davies MC, Haskell-Luevano C, Holzgrabe U, Huang R, Lagiakos HR, Leftheris K, Martin Y, Matos MJ, May-Dracka TL, Müller CE, Newman AH, Parmee E, Petter JC, Tamayo NA, Wexler RR, Bolognesi ML, Ripka A, Young W. Blanco MJ, et al. Among authors: newman ah. ACS Med Chem Lett. 2024 Mar 8;15(4):424-431. doi: 10.1021/acsmedchemlett.4c00097. eCollection 2024 Apr 11. ACS Med Chem Lett. 2024. PMID: 38628790
Development of novel tools for dissection of central versus peripheral dopamine D2-like receptor signaling in dysglycemia.
Bonifazi A, Ellenberger M, Farino ZJ, Aslanoglou D, Rais R, Pereira S, Mantilla-Rivas JO, Boateng CA, Eshleman AJ, Janowsky A, Hahn MK, Schwartz GJ, Slusher BS, Newman AH, Freyberg Z. Bonifazi A, et al. Among authors: newman ah. bioRxiv [Preprint]. 2024 Feb 24:2024.02.21.581451. doi: 10.1101/2024.02.21.581451. bioRxiv. 2024. PMID: 38529497 Free PMC article. Preprint.
Empowering Voices: Inspiring Women in Medicinal Chemistry.
Blanco MJ, Bronson JJ, DiMauro EF, Dzierba C, Eggen M, Garner AL, Georg G, Giarolla J, Goodwin NC, Grenier-Davies MC, Haskell-Luevano C, Holzgrabe U, Huang R, Lagiakos HR, Leftheris K, Martin Y, Matos MJ, May-Dracka TL, Müller CE, Newman AH, Parmee E, Petter JC, Tamayo NA, Wexler RR, Bolognesi ML, Ripka A, Young W. Blanco MJ, et al. Among authors: newman ah. J Med Chem. 2024 Mar 28;67(6):4251-4258. doi: 10.1021/acs.jmedchem.4c00493. Epub 2024 Mar 8. J Med Chem. 2024. PMID: 38456628
323 results