Nguyen B - Search Results

1

Design, synthesis, and activity of a series of pyrrolidine-3-carboxylic acid-based, highly specific, orally active ET(B) antagonists containing a diphenylmethylamine acetamide side chain.

Liu G, Kozmina NS, Winn M, von Geldern TW, Chiou WJ, Dixon DB, Nguyen B, Marsh KC, Opgenorth TJ. Liu G, et al. Among authors: nguyen b. J Med Chem. 1999 Sep 9;42(18):3679-89. doi: 10.1021/jm990171i. J Med Chem. 1999. PMID: 10479299

2

The effects of diminishing albumin binding to some Endothelin receptor antagonists.

Szczepankiewicz BG, Bal RB, von Geldern TW, Wu-Wong JR, Chiou WJ, Dixon DB, Opgenorth TJ, Hoffman DJ, Borre AJ, Marsh KC, Nguyen BN. Szczepankiewicz BG, et al. Among authors: nguyen bn. Life Sci. 1998;63(21):1905-12. doi: 10.1016/s0024-3205(98)00466-4. Life Sci. 1998. PMID: 9825768

3

Pyrrolidine-3-carboxylic acids as endothelin antagonists. 2. Sulfonamide-based ETA/ETB mixed antagonists.

Jae HS, Winn M, Dixon DB, Marsh KC, Nguyen B, Opgenorth TJ, von Geldern TW. Jae HS, et al. Among authors: nguyen b. J Med Chem. 1997 Sep 26;40(20):3217-27. doi: 10.1021/jm970101g. J Med Chem. 1997. PMID: 9379441

4

Pyrrolidine-3-carboxylic acids as endothelin antagonists. 3. Discovery of a potent, 2-nonaryl, highly selective ETA antagonist (A-216546).

Liu G, Henry KJ Jr, Szczepankiewicz BG, Winn M, Kozmina NS, Boyd SA, Wasicak J, von Geldern TW, Wu-Wong JR, Chiou WJ, Dixon DB, Nguyen B, Marsh KC, Opgenorth TJ. Liu G, et al. Among authors: nguyen b. J Med Chem. 1998 Aug 13;41(17):3261-75. doi: 10.1021/jm980217s. J Med Chem. 1998. PMID: 9703472

5

Discovery of a series of pyrrolidine-based endothelin receptor antagonists with enhanced ET(A) receptor selectivity.

Boyd SA, Mantei RA, Tasker AS, Liu G, Sorensen BK, Henry KJ Jr, von Geldern TW, Winn M, Wu-Wong JR, Chiou WJ, Dixon DB, Hutchins CW, Marsh KC, Nguyen B, Opgenorth TJ. Boyd SA, et al. Among authors: nguyen b. Bioorg Med Chem. 1999 Jun;7(6):991-1002. doi: 10.1016/s0968-0896(99)00022-x. Bioorg Med Chem. 1999. PMID: 10428367

6

Pyrrolidine-3-carboxylic acids as endothelin antagonists. 4. Side chain conformational restriction leads to ET(B) selectivity.

von Geldern TW, Tasker AS, Sorensen BK, Winn M, Szczepankiewicz BG, Dixon DB, Chiou WJ, Wang L, Wessale JL, Adler A, Marsh KC, Nguyen B, Opgenorth TJ. von Geldern TW, et al. Among authors: nguyen b. J Med Chem. 1999 Sep 9;42(18):3668-78. doi: 10.1021/jm990170q. J Med Chem. 1999. PMID: 10479298

7

Discovery of novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intracellular adhesion molecule-1 interaction. 1. Identification of an additional binding pocket based on an anilino diaryl sulfide lead.

Liu G, Link JT, Pei Z, Reilly EB, Leitza S, Nguyen B, Marsh KC, Okasinski GF, von Geldern TW, Ormes M, Fowler K, Gallatin M. Liu G, et al. Among authors: nguyen b. J Med Chem. 2000 Oct 19;43(21):4025-40. doi: 10.1021/jm0002782. J Med Chem. 2000. PMID: 11052808

8

Pyrrolidine-3-carboxylic acids as endothelin antagonists. 5. Highly selective, potent, and orally active ET(A) antagonists.

Jae HS, Winn M, von Geldern TW, Sorensen BK, Chiou WJ, Nguyen B, Marsh KC, Opgenorth TJ. Jae HS, et al. Among authors: nguyen b. J Med Chem. 2001 Nov 8;44(23):3978-84. doi: 10.1021/jm010237l. J Med Chem. 2001. PMID: 11689084

9

Thrombospondin-1 mimetic peptide inhibitors of angiogenesis and tumor growth: design, synthesis, and optimization of pharmacokinetics and biological activities.

Haviv F, Bradley MF, Kalvin DM, Schneider AJ, Davidson DJ, Majest SM, McKay LM, Haskell CJ, Bell RL, Nguyen B, Marsh KC, Surber BW, Uchic JT, Ferrero J, Wang YC, Leal J, Record RD, Hodde J, Badylak SF, Lesniewski RR, Henkin J. Haviv F, et al. Among authors: nguyen b. J Med Chem. 2005 Apr 21;48(8):2838-46. doi: 10.1021/jm0401560. J Med Chem. 2005. PMID: 15828822

10

2-Pyridyl P1'-substituted symmetry-based human immunodeficiency virus protease inhibitors (A-792611 and A-790742) with potential for convenient dosing and reduced side effects.

Degoey DA, Grampovnik DJ, Flentge CA, Flosi WJ, Chen HJ, Yeung CM, Randolph JT, Klein LL, Dekhtyar T, Colletti L, Marsh KC, Stoll V, Mamo M, Morfitt DC, Nguyen B, Schmidt JM, Swanson SJ, Mo H, Kati WM, Molla A, Kempf DJ. Degoey DA, et al. Among authors: nguyen b. J Med Chem. 2009 Apr 23;52(8):2571-86. doi: 10.1021/jm900044w. J Med Chem. 2009. PMID: 19323562

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