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Potent inhibitors of platelet aggregation based upon the Arg-Gly-Asp-Phe sequence of fibrinogen. A proposal on the nature of the binding interaction between the Asp-carboxylate of RGDX mimetics and the platelet GP IIb-IIIa receptor.
Zablocki JA, Miyano M, Rao SN, Panzer-Knodle S, Nicholson N, Feigen L. Zablocki JA, et al. Among authors: nicholson n. J Med Chem. 1992 Dec 25;35(26):4914-7. doi: 10.1021/jm00104a019. J Med Chem. 1992. PMID: 1479591 No abstract available.
SC-49992--a potent and specific inhibitor of platelet aggregation.
Nicholson NS, Panzer-Knodle SG, King LW, Taite BB, Keller BT, Tjoeng FS, Engleman VW, Giorgio TD, Feigen LP. Nicholson NS, et al. Thromb Res. 1994 Jun 1;74(5):523-35. doi: 10.1016/0049-3848(94)90273-9. Thromb Res. 1994. PMID: 8085253
Potent in vitro and in vivo inhibitors of platelet aggregation based upon the Arg-Gly-Asp-Phe sequence of fibrinogen. A proposal on the nature of the binding interaction between the Arg-guanidine of RGDX mimetics and the platelet GP IIb-IIIa receptor.
Zablocki JA, Miyano M, Garland RB, Pireh D, Schretzman L, Rao SN, Lindmark RJ, Panzer-Knodle SG, Nicholson NS, Taite BB, et al. Zablocki JA, et al. Among authors: nicholson ns. J Med Chem. 1993 Jun 25;36(13):1811-9. doi: 10.1021/jm00065a003. J Med Chem. 1993. PMID: 8515420
SC-49992, a mimetic of the peptide arginine-glycine-aspartic acid-phenylalanine that blocks platelet aggregation, enhances recombinant tissue plasminogen activator-induced thrombolysis and prevents reocclusion in a canine model of coronary artery thrombosis.
Feigen LP, Nicholson NS, King LW, Campion JG, Tjoeng FS, Panzer-Knodle SG. Feigen LP, et al. Among authors: nicholson ns. J Pharmacol Exp Ther. 1993 Dec;267(3):1191-7. J Pharmacol Exp Ther. 1993. PMID: 8263779
Assessment of platelet function assays.
Nicholson NS, Panzer-Knodle SG, Haas NF, Taite BB, Szalony JA, Page JD, Feigen LP, Lansky DM, Salyers AK. Nicholson NS, et al. Am Heart J. 1998 May;135(5 Pt 2 Su):S170-8. doi: 10.1016/s0002-8703(98)70245-5. Am Heart J. 1998. PMID: 9588396 Review.
140 results