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The synthesis of novel GABA uptake inhibitors. 1. Elucidation of the structure-activity studies leading to the choice of (R)-1-[4,4-bis(3-methyl-2-thienyl)-3-butenyl]-3-piperidinecarboxylic acid (tiagabine) as an anticonvulsant drug candidate.
Andersen KE, Braestrup C, Grønwald FC, Jørgensen AS, Nielsen EB, Sonnewald U, Sørensen PO, Suzdak PD, Knutsen LJ. Andersen KE, et al. Among authors: nielsen eb. J Med Chem. 1993 Jun 11;36(12):1716-25. doi: 10.1021/jm00064a005. J Med Chem. 1993. PMID: 8510100
Future directions in anxiety research.
Braestrup C, Nielsen EB. Braestrup C, et al. Among authors: nielsen eb. Psychopharmacol Ser. 1988;5:180-6. doi: 10.1007/978-3-642-73280-5_17. Psychopharmacol Ser. 1988. PMID: 2901081 Review.
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