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A cell-based screening for TAZ activators identifies ethacridine, a widely used antiseptic and abortifacient, as a compound that promotes dephosphorylation of TAZ and inhibits adipogenesis in C3H10T1/2 cells.
Kawano S, Maruyama J, Nagashima S, Inami K, Qiu W, Iwasa H, Nakagawa K, Ishigami-Yuasa M, Kagechika H, Nishina H, Hata Y. Kawano S, et al. Among authors: nishina h. J Biochem. 2015 Nov;158(5):413-23. doi: 10.1093/jb/mvv051. Epub 2015 May 14. J Biochem. 2015. PMID: 25979969
Screening with a novel cell-based assay for TAZ activators identifies a compound that enhances myogenesis in C2C12 cells and facilitates muscle repair in a muscle injury model.
Yang Z, Nakagawa K, Sarkar A, Maruyama J, Iwasa H, Bao Y, Ishigami-Yuasa M, Ito S, Kagechika H, Hata S, Nishina H, Abe S, Kitagawa M, Hata Y. Yang Z, et al. Among authors: nishina h. Mol Cell Biol. 2014 May;34(9):1607-21. doi: 10.1128/MCB.01346-13. Epub 2014 Feb 18. Mol Cell Biol. 2014. PMID: 24550007 Free PMC article.
Validation of chemical compound library screening for transcriptional co-activator with PDZ-binding motif inhibitors using GFP-fused transcriptional co-activator with PDZ-binding motif.
Nagashima S, Maruyama J, Kawano S, Iwasa H, Nakagawa K, Ishigami-Yuasa M, Kagechika H, Nishina H, Hata Y. Nagashima S, et al. Among authors: nishina h. Cancer Sci. 2016 Jun;107(6):791-802. doi: 10.1111/cas.12936. Epub 2016 May 12. Cancer Sci. 2016. PMID: 27009852 Free PMC article.
Characterization of a novel compound that promotes myogenesis via Akt and transcriptional co-activator with PDZ-binding motif (TAZ) in mouse C2C12 cells.
Kodaka M, Mao F, Arimoto-Matsuzaki K, Kitamura M, Xu X, Yang Z, Nakagawa K, Maruyama J, Ishii K, Akazawa C, Oyaizu T, Yamamoto N, Ishigami-Yuasa M, Tsuemoto N, Ito S, Kagechika H, Nishina H, Hata Y. Kodaka M, et al. Among authors: nishina h. PLoS One. 2020 Apr 8;15(4):e0231265. doi: 10.1371/journal.pone.0231265. eCollection 2020. PLoS One. 2020. PMID: 32267872 Free PMC article.
CSE1L promotes nuclear accumulation of transcriptional coactivator TAZ and enhances invasiveness of human cancer cells.
Nagashima S, Maruyama J, Honda K, Kondoh Y, Osada H, Nawa M, Nakahama KI, Ishigami-Yuasa M, Kagechika H, Sugimura H, Iwasa H, Arimoto-Matsuzaki K, Nishina H, Hata Y. Nagashima S, et al. Among authors: nishina h. J Biol Chem. 2021 Jul;297(1):100803. doi: 10.1016/j.jbc.2021.100803. Epub 2021 May 20. J Biol Chem. 2021. PMID: 34022224 Free PMC article.
Blockage by SP600125 of Fcepsilon receptor-induced degranulation and cytokine gene expression in mast cells is mediated through inhibition of phosphatidylinositol 3-kinase signalling pathway.
Tanemura S, Momose H, Shimizu N, Kitagawa D, Seo J, Yamasaki T, Nakagawa K, Kajiho H, Penninger JM, Katada T, Nishina H. Tanemura S, et al. Among authors: nishina h. J Biochem. 2009 Mar;145(3):345-54. doi: 10.1093/jb/mvn172. Epub 2008 Dec 23. J Biochem. 2009. PMID: 19106158
304 results