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49 results

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Mitochondrial damage activates the NLRP10 inflammasome.
Próchnicki T, Vasconcelos MB, Robinson KS, Mangan MSJ, De Graaf D, Shkarina K, Lovotti M, Standke L, Kaiser R, Stahl R, Duthie FG, Rothe M, Antonova K, Jenster LM, Lau ZH, Rösing S, Mirza N, Gottschild C, Wachten D, Günther C, Kufer TA, Schmidt FI, Zhong FL, Latz E. Próchnicki T, et al. Nat Immunol. 2023 Apr;24(4):595-603. doi: 10.1038/s41590-023-01451-y. Epub 2023 Mar 20. Nat Immunol. 2023. PMID: 36941400
The triggers and activation mechanisms of several inflammasome-forming sensors are not well understood. Here we show that mitochondrial damage activates the NLRP10 inflammasome, leading to ASC speck formation and caspase-1-dependent cytokine release. ...NLRP10 is hi …
The triggers and activation mechanisms of several inflammasome-forming sensors are not well understood. Here we show that mitochondrial dama …
Epithelial Nlrp10 inflammasome mediates protection against intestinal autoinflammation.
Zheng D, Mohapatra G, Kern L, He Y, Shmueli MD, Valdés-Mas R, Kolodziejczyk AA, Próchnicki T, Vasconcelos MB, Schorr L, Hertel F, Lee YS, Rufino MC, Ceddaha E, Shimshy S, Hodgetts RJ, Dori-Bachash M, Kleimeyer C, Goldenberg K, Heinemann M, Stettner N, Harmelin A, Shapiro H, Puschhof J, Chen M, Flavell RA, Latz E, Merbl Y, Abdeen SK, Elinav E. Zheng D, et al. Nat Immunol. 2023 Apr;24(4):585-594. doi: 10.1038/s41590-023-01450-z. Epub 2023 Mar 20. Nat Immunol. 2023. PMID: 36941399
Here we show that mouse Nlrp10 is expressed in distal colonic intestinal epithelial cells (IECs) and modulated by the intestinal microbiome. ...In vivo, Nlrp10 signaling is dispensable during steady state but becomes functional during autoinflammation in antagonizin …
Here we show that mouse Nlrp10 is expressed in distal colonic intestinal epithelial cells (IECs) and modulated by the intestinal micr …
Ten things to know about NLRP10.
Masters SL. Masters SL. Nat Immunol. 2023 Apr;24(4):561-562. doi: 10.1038/s41590-023-01466-5. Nat Immunol. 2023. PMID: 36949288 No abstract available.
NLRP10 ablation protects against ischemia/reperfusion-associated brain injury by suppression of neuroinflammation.
Li ZG, Shui SF, Han XW, Yan L. Li ZG, et al. Exp Cell Res. 2020 Apr 15;389(2):111912. doi: 10.1016/j.yexcr.2020.111912. Epub 2020 Feb 19. Exp Cell Res. 2020. PMID: 32084391
The results above were mainly verified in LPS-incubated astrocytes in the absence of NLRP10. Correspondingly, in LPS-treated astrocytes, NLRP10 knockout-reduced inflammation via impairing TLR-4/NF-kappaB and NLRP12/ASC/Caspase-1 pathways was evidently restored by ov …
The results above were mainly verified in LPS-incubated astrocytes in the absence of NLRP10. Correspondingly, in LPS-treated astrocyt …
NLRP10 Affects the Stability of Abin-1 To Control Inflammatory Responses.
Mirza N, Sowa AS, Lautz K, Kufer TA. Mirza N, et al. J Immunol. 2019 Jan 1;202(1):218-227. doi: 10.4049/jimmunol.1800334. Epub 2018 Dec 3. J Immunol. 2019. PMID: 30510071
In this study, we identify Abin-1, a negative regulator of NF-kappaB, as an interaction partner of NLRP10 that binds to the NACHT domain of NLRP10. Using S. flexneri as an infection model in human epithelial cells, our work reveals a novel function of NLRP10 …
In this study, we identify Abin-1, a negative regulator of NF-kappaB, as an interaction partner of NLRP10 that binds to the NACHT dom …
Cigarette smoke-induced inflammation: NLRP10-mediated mechanisms.
Kaur G, Bagam P, Pinkston R, Singh DP, Batra S. Kaur G, et al. Toxicology. 2018 Apr 1;398-399:52-67. doi: 10.1016/j.tox.2018.02.010. Epub 2018 Mar 6. Toxicology. 2018. PMID: 29501574
Therefore, instead of functioning as a PRR, NLRP10 may have a broader regulatory role. To elucidate the role of NLRP10 in secondhand smoke (SHS)-induced inflammation, we exposed C57Bl/6 (WT) and Nlrp10-deficient mice (Nlrp10(-/-)) on the C57Bl/6 backgr …
Therefore, instead of functioning as a PRR, NLRP10 may have a broader regulatory role. To elucidate the role of NLRP10 in seco …
Epidermal NLRP10 contributes to contact hypersensitivity responses in mice.
Damm A, Giebeler N, Zamek J, Zigrino P, Kufer TA. Damm A, et al. Eur J Immunol. 2016 Aug;46(8):1959-69. doi: 10.1002/eji.201646401. Epub 2016 Jun 16. Eur J Immunol. 2016. PMID: 27221772 Free article.
Nlrp10(-/-) mice were phenotypically normal and skin repair after wounding was not affected by lack of NLRP10. ...Taken together, we provide evidence that NLRP10 contributes to T-cell-mediated inflammatory responses in the skin and highlight a physiological r …
Nlrp10(-/-) mice were phenotypically normal and skin repair after wounding was not affected by lack of NLRP10. ...Taken togeth …
Roles of NLRP10 in innate and adaptive immunity.
Damm A, Lautz K, Kufer TA. Damm A, et al. Microbes Infect. 2013 Jun;15(6-7):516-23. doi: 10.1016/j.micinf.2013.03.008. Epub 2013 Apr 4. Microbes Infect. 2013. PMID: 23562614 Free article. Review.
Here we review first insights into the molecular function of NLRP10 highlighting the role of this specific NLR in innate and adaptive immune responses....
Here we review first insights into the molecular function of NLRP10 highlighting the role of this specific NLR in innate and adaptive …
NLRP10 Enhances CD4(+) T-Cell-Mediated IFNgamma Response via Regulation of Dendritic Cell-Derived IL-12 Release.
Vacca M, Böhme J, Zambetti LP, Khameneh HJ, Paleja BS, Laudisi F, Ho AWS, Neo K, Leong KWK, Marzuki M, Lee B, Poidinger M, Santambrogio L, Tsenova L, Zolezzi F, De Libero G, Singhal A, Mortellaro A. Vacca M, et al. Front Immunol. 2017 Nov 2;8:1462. doi: 10.3389/fimmu.2017.01462. eCollection 2017. Front Immunol. 2017. PMID: 29163529 Free PMC article.
NLRP10 is a nucleotide-binding oligomerization domain-like receptor that functions as an intracellular pattern recognition receptor for microbial products. Here, we generated a Nlrp10(-/-) mouse to delineate the role of NLRP10 in the host immune response and …
NLRP10 is a nucleotide-binding oligomerization domain-like receptor that functions as an intracellular pattern recognition receptor f …
NLRP10 enhances Shigella-induced pro-inflammatory responses.
Lautz K, Damm A, Menning M, Wenger J, Adam AC, Zigrino P, Kremmer E, Kufer TA. Lautz K, et al. Cell Microbiol. 2012 Oct;14(10):1568-83. doi: 10.1111/j.1462-5822.2012.01822.x. Epub 2012 Jun 21. Cell Microbiol. 2012. PMID: 22672233
This effect is dependent on the ATPase activity of NLRP10 and its PYD domain. Mechanistically, NLRP10 interacts with NOD1, a NLR that is pivotally involved in sensing of invasive microbes, and both proteins are recruited to the bacterial entry point at the plasma me …
This effect is dependent on the ATPase activity of NLRP10 and its PYD domain. Mechanistically, NLRP10 interacts with NOD1, a N …
49 results