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SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function.
Price NL, Gomes AP, Ling AJ, Duarte FV, Martin-Montalvo A, North BJ, Agarwal B, Ye L, Ramadori G, Teodoro JS, Hubbard BP, Varela AT, Davis JG, Varamini B, Hafner A, Moaddel R, Rolo AP, Coppari R, Palmeira CM, de Cabo R, Baur JA, Sinclair DA. Price NL, et al. Among authors: north bj. Cell Metab. 2012 May 2;15(5):675-90. doi: 10.1016/j.cmet.2012.04.003. Cell Metab. 2012. PMID: 22560220 Free PMC article.
Sirtuins: a conserved key unlocking AceCS activity.
North BJ, Sinclair DA. North BJ, et al. Trends Biochem Sci. 2007 Jan;32(1):1-4. doi: 10.1016/j.tibs.2006.11.002. Epub 2006 Dec 1. Trends Biochem Sci. 2007. PMID: 17141505 Free PMC article.
SIRT2 induces the checkpoint kinase BubR1 to increase lifespan.
North BJ, Rosenberg MA, Jeganathan KB, Hafner AV, Michan S, Dai J, Baker DJ, Cen Y, Wu LE, Sauve AA, van Deursen JM, Rosenzweig A, Sinclair DA. North BJ, et al. EMBO J. 2014 Jul 1;33(13):1438-53. doi: 10.15252/embj.201386907. Epub 2014 May 12. EMBO J. 2014. PMID: 24825348 Free PMC article.
Selective Sirt2 inhibition by ligand-induced rearrangement of the active site.
Rumpf T, Schiedel M, Karaman B, Roessler C, North BJ, Lehotzky A, Oláh J, Ladwein KI, Schmidtkunz K, Gajer M, Pannek M, Steegborn C, Sinclair DA, Gerhardt S, Ovádi J, Schutkowski M, Sippl W, Einsle O, Jung M. Rumpf T, et al. Among authors: north bj. Nat Commun. 2015 Feb 12;6:6263. doi: 10.1038/ncomms7263. Nat Commun. 2015. PMID: 25672491 Free PMC article.
Sir-two-homolog 2 (Sirt2) modulates peripheral myelination through polarity protein Par-3/atypical protein kinase C (aPKC) signaling.
Beirowski B, Gustin J, Armour SM, Yamamoto H, Viader A, North BJ, Michán S, Baloh RH, Golden JP, Schmidt RE, Sinclair DA, Auwerx J, Milbrandt J. Beirowski B, et al. Among authors: north bj. Proc Natl Acad Sci U S A. 2011 Oct 25;108(43):E952-61. doi: 10.1073/pnas.1104969108. Epub 2011 Sep 26. Proc Natl Acad Sci U S A. 2011. PMID: 21949390 Free PMC article.
Acetylation-dependent regulation of PD-L1 nuclear translocation dictates the efficacy of anti-PD-1 immunotherapy.
Gao Y, Nihira NT, Bu X, Chu C, Zhang J, Kolodziejczyk A, Fan Y, Chan NT, Ma L, Liu J, Wang D, Dai X, Liu H, Ono M, Nakanishi A, Inuzuka H, North BJ, Huang YH, Sharma S, Geng Y, Xu W, Liu XS, Li L, Miki Y, Sicinski P, Freeman GJ, Wei W. Gao Y, et al. Among authors: north bj. Nat Cell Biol. 2020 Sep;22(9):1064-1075. doi: 10.1038/s41556-020-0562-4. Epub 2020 Aug 24. Nat Cell Biol. 2020. PMID: 32839551 Free PMC article.
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