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Page 1
T Cell Activation Depends on Extracellular Alanine.
Ron-Harel N, Ghergurovich JM, Notarangelo G, LaFleur MW, Tsubosaka Y, Sharpe AH, Rabinowitz JD, Haigis MC. Ron-Harel N, et al. Among authors: notarangelo g. Cell Rep. 2019 Sep 17;28(12):3011-3021.e4. doi: 10.1016/j.celrep.2019.08.034. Cell Rep. 2019. PMID: 31533027 Free PMC article.
Defective respiration and one-carbon metabolism contribute to impaired naïve T cell activation in aged mice.
Ron-Harel N, Notarangelo G, Ghergurovich JM, Paulo JA, Sage PT, Santos D, Satterstrom FK, Gygi SP, Rabinowitz JD, Sharpe AH, Haigis MC. Ron-Harel N, et al. Among authors: notarangelo g. Proc Natl Acad Sci U S A. 2018 Dec 26;115(52):13347-13352. doi: 10.1073/pnas.1804149115. Epub 2018 Dec 10. Proc Natl Acad Sci U S A. 2018. PMID: 30530686 Free PMC article.
SIRT4 is an early regulator of branched-chain amino acid catabolism that promotes adipogenesis.
Zaganjor E, Yoon H, Spinelli JB, Nunn ER, Laurent G, Keskinidis P, Sivaloganathan S, Joshi S, Notarangelo G, Mulei S, Chvasta MT, Tucker SA, Kalafut K, van de Ven RAH, Clish CB, Haigis MC. Zaganjor E, et al. Among authors: notarangelo g. Cell Rep. 2021 Jul 13;36(2):109345. doi: 10.1016/j.celrep.2021.109345. Cell Rep. 2021. PMID: 34260923 Free PMC article.
Oncometabolite d-2HG alters T cell metabolism to impair CD8+ T cell function.
Notarangelo G, Spinelli JB, Perez EM, Baker GJ, Kurmi K, Elia I, Stopka SA, Baquer G, Lin JR, Golby AJ, Joshi S, Baron HF, Drijvers JM, Georgiev P, Ringel AE, Zaganjor E, McBrayer SK, Sorger PK, Sharpe AH, Wucherpfennig KW, Santagata S, Agar NYR, Suvà ML, Haigis MC. Notarangelo G, et al. Science. 2022 Sep 30;377(6614):1519-1529. doi: 10.1126/science.abj5104. Epub 2022 Sep 29. Science. 2022. PMID: 36173860 Free PMC article.
Metabolic modulation of mitochondrial mass during CD4+ T cell activation.
Kurmi K, Liang D, van de Ven R, Georgiev P, Gassaway BM, Han S, Notarangelo G, Harris IS, Yao CH, Park JS, Hu SH, Peng J, Drijvers JM, Boswell S, Sokolov A, Dougan SK, Sorger PK, Gygi SP, Sharpe AH, Haigis MC. Kurmi K, et al. Among authors: notarangelo g. Cell Chem Biol. 2023 Sep 21;30(9):1064-1075.e8. doi: 10.1016/j.chembiol.2023.08.008. Cell Chem Biol. 2023. PMID: 37716347
Mitochondrial Reprogramming Underlies Resistance to BCL-2 Inhibition in Lymphoid Malignancies.
Guièze R, Liu VM, Rosebrock D, Jourdain AA, Hernández-Sánchez M, Martinez Zurita A, Sun J, Ten Hacken E, Baranowski K, Thompson PA, Heo JM, Cartun Z, Aygün O, Iorgulescu JB, Zhang W, Notarangelo G, Livitz D, Li S, Davids MS, Biran A, Fernandes SM, Brown JR, Lako A, Ciantra ZB, Lawlor MA, Keskin DB, Udeshi ND, Wierda WG, Livak KJ, Letai AG, Neuberg D, Harper JW, Carr SA, Piccioni F, Ott CJ, Leshchiner I, Johannessen CM, Doench J, Mootha VK, Getz G, Wu CJ. Guièze R, et al. Among authors: notarangelo g. Cancer Cell. 2019 Oct 14;36(4):369-384.e13. doi: 10.1016/j.ccell.2019.08.005. Epub 2019 Sep 19. Cancer Cell. 2019. PMID: 31543463 Free PMC article.
Defective glycosylation and multisystem abnormalities characterize the primary immunodeficiency XMEN disease.
Ravell JC, Matsuda-Lennikov M, Chauvin SD, Zou J, Biancalana M, Deeb SJ, Price S, Su HC, Notarangelo G, Jiang P, Morawski A, Kanellopoulou C, Binder K, Mukherjee R, Anibal JT, Sellers B, Zheng L, He T, George AB, Pittaluga S, Powers A, Kleiner DE, Kapuria D, Ghany M, Hunsberger S, Cohen JI, Uzel G, Bergerson J, Wolfe L, Toro C, Gahl W, Folio LR, Matthews H, Angelus P, Chinn IK, Orange JS, Trujillo-Vargas CM, Franco JL, Orrego-Arango J, Gutiérrez-Hincapié S, Patel NC, Raymond K, Patiroglu T, Unal E, Karakukcu M, Day AG, Mehta P, Masutani E, De Ravin SS, Malech HL, Altan-Bonnet G, Rao VK, Mann M, Lenardo MJ. Ravell JC, et al. Among authors: notarangelo g. J Clin Invest. 2020 Jan 2;130(1):507-522. doi: 10.1172/JCI131116. J Clin Invest. 2020. PMID: 31714901 Free PMC article.
14 results