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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1980 1
1988 2
1992 2
1993 1
1994 2
1995 3
1996 5
1997 6
1998 11
1999 11
2000 18
2001 24
2002 18
2003 32
2004 35
2005 27
2006 24
2007 43
2008 68
2009 70
2010 69
2011 89
2012 107
2013 115
2014 127
2015 119
2016 117
2017 161
2018 171
2019 135
2020 184
2021 157
2022 172
2023 139
2024 63

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2,055 results

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Page 1
NOTCH2 related disorders: Description and review of the fetal presentation.
Deb W, Joubert M, Cogné B, Vincent M, Ghesh L, Bézieau S, Le Vaillant C, Beneteau C. Deb W, et al. Eur J Med Genet. 2023 Jul;66(7):104769. doi: 10.1016/j.ejmg.2023.104769. Epub 2023 Apr 28. Eur J Med Genet. 2023. PMID: 37121269 Review.
After fetopathological and radiological examinations, Exome Sequencing (ES) was performed and revealed a de novo truncating mutation in the last exon of NOTCH2, responsible for Hajdu-Cheney or Serpentine Fibula Polycystic Kidney syndromes....
After fetopathological and radiological examinations, Exome Sequencing (ES) was performed and revealed a de novo truncating mutation in the …
Alagille syndrome mutation update: Comprehensive overview of JAG1 and NOTCH2 mutation frequencies and insight into missense variant classification.
Gilbert MA, Bauer RC, Rajagopalan R, Grochowski CM, Chao G, McEldrew D, Nassur JA, Rand EB, Krock BL, Kamath BM, Krantz ID, Piccoli DA, Loomes KM, Spinner NB. Gilbert MA, et al. Hum Mutat. 2019 Dec;40(12):2197-2220. doi: 10.1002/humu.23879. Epub 2019 Aug 26. Hum Mutat. 2019. PMID: 31343788 Free PMC article.
Conversely, the majority of NOTCH2 variants are missense, though fewer of these variants have been described. ...Combining our cohort of 86 novel JAG1 and three novel NOTCH2 variants with previously published data (totaling 713 variants), we present the most compreh …
Conversely, the majority of NOTCH2 variants are missense, though fewer of these variants have been described. ...Combining our cohort …
Notch2 and immune function.
Sakata-Yanagimoto M, Chiba S. Sakata-Yanagimoto M, et al. Curr Top Microbiol Immunol. 2012;360:151-61. doi: 10.1007/82_2012_235. Curr Top Microbiol Immunol. 2012. PMID: 22695918 Review.
Notch2 appears to play some specific roles in the intestinal immunity, given that the fate of mast cells and a subset of DCs is regulated by Notch2 in the intestine. ...Moreover, recent genetic evidence suggests that both gain-and loss-of-function abnormalities of …
Notch2 appears to play some specific roles in the intestinal immunity, given that the fate of mast cells and a subset of DCs is regul …
Perspectives on the discovery of NOTCH2-specific inhibitors.
Dobranowski P, Ban F, Contreras-Sanz A, Cherkasov A, Black PC. Dobranowski P, et al. Chem Biol Drug Des. 2018 Mar;91(3):691-706. doi: 10.1111/cbdd.13132. Epub 2017 Nov 15. Chem Biol Drug Des. 2018. PMID: 29078041 Review.
This perspective explores the feasibility of developing Notch-specific small molecule inhibitors targeting the anti-NOTCH2 antibody-binding epitopes or the "S2-Leu-plug-binding site" using a computer-aided drug discovery approach....
This perspective explores the feasibility of developing Notch-specific small molecule inhibitors targeting the anti-NOTCH2 antibody-b …
The role of oncogenic Notch2 signaling in cancer: a novel therapeutic target.
Xiu MX, Liu YM. Xiu MX, et al. Am J Cancer Res. 2019 May 1;9(5):837-854. eCollection 2019. Am J Cancer Res. 2019. PMID: 31218097 Free PMC article. Review.
Successful efforts to block Notch2 signaling will depend upon doing so both efficiently and specifically in patients. As such, in the present review we will explore the role of Notch2 signaling in the development and progression of cancer, and we will assess agents …
Successful efforts to block Notch2 signaling will depend upon doing so both efficiently and specifically in patients. As such, in the …
Notch2 Blockade Mitigates Methotrexate Chemotherapy-Induced Bone Loss and Marrow Adiposity.
Peymanfar Y, Su YW, Xian CJ. Peymanfar Y, et al. Cells. 2022 May 2;11(9):1521. doi: 10.3390/cells11091521. Cells. 2022. PMID: 35563828 Free PMC article.
To confirm the roles of Notch2 signalling, a neutralising anti-Notch2 antibody or a control IgG was administered to rats during MTX treatment. ...Thus, Notch2 signalling plays an important role in mediating MTX treatment-induced bone loss and bone marrow adip …
To confirm the roles of Notch2 signalling, a neutralising anti-Notch2 antibody or a control IgG was administered to rats durin …
Alagille Syndrome.
Mitchell E, Gilbert M, Loomes KM. Mitchell E, et al. Clin Liver Dis. 2018 Nov;22(4):625-641. doi: 10.1016/j.cld.2018.06.001. Epub 2018 Aug 22. Clin Liver Dis. 2018. PMID: 30266153 Review.
A majority of patients have pathogenic mutations in either the JAG1 gene, encoding a Notch pathway ligand, or the receptor NOTCH2. No genotype-phenotype correlations have been found in any organ system. ...
A majority of patients have pathogenic mutations in either the JAG1 gene, encoding a Notch pathway ligand, or the receptor NOTCH2. No …
NOTCH2 sensitizes the chondrocyte to the inflammatory response of tumor necrosis factor alpha.
Canalis E, Yu J, Singh V, Mocarska M, Schilling L. Canalis E, et al. J Biol Chem. 2023 Dec;299(12):105372. doi: 10.1016/j.jbc.2023.105372. Epub 2023 Oct 20. J Biol Chem. 2023. PMID: 37865314 Free PMC article.
We examined the effects of tumor necrosis factor alpha (TNFalpha) in chondrocytes from Notch2(tm1.1Ecan) mice and found that NOTCH2 enhanced the effect of TNFalpha on Il6 and Il1b expression. Similar results were obtained in cells from a conditional model of NOTC …
We examined the effects of tumor necrosis factor alpha (TNFalpha) in chondrocytes from Notch2(tm1.1Ecan) mice and found that NOTCH …
A brief overview of clinical significance of novel Notch2 regulators.
Pancewicz J. Pancewicz J. Mol Cell Oncol. 2020 Jun 30;7(5):1776084. doi: 10.1080/23723556.2020.1776084. eCollection 2020. Mol Cell Oncol. 2020. PMID: 32944632 Free PMC article. Review.
Consequently, Notch2 function in the carcinogenesis process is unquestionable, whereas information according to the effect of its inhibition in tumor is still obscure. Hence, the aim of our study was to evaluate the current state of knowledge conferring Notch2 inhib …
Consequently, Notch2 function in the carcinogenesis process is unquestionable, whereas information according to the effect of its inh …
Notch2-mediated plasticity between marginal zone and follicular B cells.
Lechner M, Engleitner T, Babushku T, Schmidt-Supprian M, Rad R, Strobl LJ, Zimber-Strobl U. Lechner M, et al. Nat Commun. 2021 Feb 17;12(1):1111. doi: 10.1038/s41467-021-21359-1. Nat Commun. 2021. PMID: 33597542 Free PMC article.
In the B cell follicle, a Notch2-signal is provided by DLL-1-expressing fibroblasts. However, it is unclear whether FoB cells, which are in close contact with these DLL-1 expressing fibroblasts, can also differentiate to MZB cells if they receive a Notch2-signal. .. …
In the B cell follicle, a Notch2-signal is provided by DLL-1-expressing fibroblasts. However, it is unclear whether FoB cells, which …
2,055 results