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2000 2
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754 results

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Page 1
The role of NPC1L1 in cancer.
Zhang R, Zeng J, Liu W, Meng J, Wang C, Shi L, Yang S, Chang J, Xing D. Zhang R, et al. Front Pharmacol. 2022 Aug 10;13:956619. doi: 10.3389/fphar.2022.956619. eCollection 2022. Front Pharmacol. 2022. PMID: 36034854 Free PMC article. Review.
NPC1L1 also has the potential to develop into a new therapeutic target and a cancer marker. There is, however, no comprehensive review that summarizes NPC1L1's function in cancer. To this end, we outlined NPC1L1's functions in carcinogenesis and treatment, al …
NPC1L1 also has the potential to develop into a new therapeutic target and a cancer marker. There is, however, no comprehensive revie …
Inhibition of NPC1L1 disrupts adaptive responses of drug-tolerant persister cells to chemotherapy.
Zhang Z, Qin S, Chen Y, Zhou L, Yang M, Tang Y, Zuo J, Zhang J, Mizokami A, Nice EC, Chen HN, Huang C, Wei X. Zhang Z, et al. EMBO Mol Med. 2022 Feb 7;14(2):e14903. doi: 10.15252/emmm.202114903. Epub 2022 Jan 13. EMBO Mol Med. 2022. PMID: 35023619 Free PMC article.
Characterization of MDR cancer cells with a DTP state by RNA-seq revealed that these cells partially prevented chemotherapy-triggered oxidative stress by promoting NPC1L1-regulated uptake of vitamin E. Treatment with the NPC1L1 inhibitor ezetimibe further enhanced t …
Characterization of MDR cancer cells with a DTP state by RNA-seq revealed that these cells partially prevented chemotherapy-triggered oxidat …
Bile acids-mediated intracellular cholesterol transport promotes intestinal cholesterol absorption and NPC1L1 recycling.
Xiao J, Dong LW, Liu S, Meng FH, Xie C, Lu XY, Zhang WJ, Luo J, Song BL. Xiao J, et al. Nat Commun. 2023 Oct 13;14(1):6469. doi: 10.1038/s41467-023-42179-5. Nat Commun. 2023. PMID: 37833289 Free PMC article.
Niemann-Pick C1-like 1 (NPC1L1) is essential for intestinal cholesterol absorption. Together with the cholesterol-rich and Flotillin-positive membrane microdomain, NPC1L1 is internalized via clathrin-mediated endocytosis and transported to endocytic recycling compar …
Niemann-Pick C1-like 1 (NPC1L1) is essential for intestinal cholesterol absorption. Together with the cholesterol-rich and Flotillin- …
Associations of genetically proxied inhibition of HMG-CoA reductase, NPC1L1, and PCSK9 with breast cancer and prostate cancer.
Sun L, Ding H, Jia Y, Shi M, Guo D, Yang P, Wang Y, Liu F, Zhang Y, Zhu Z. Sun L, et al. Breast Cancer Res. 2022 Feb 12;24(1):12. doi: 10.1186/s13058-022-01508-0. Breast Cancer Res. 2022. PMID: 35151363 Free PMC article.
METHODS: Single-nucleotide polymorphisms (SNPs) in HMGCR, NPC1L1, and PCSK9 associated with LDL-C in a genome-wide association study (GWAS) meta-analysis from the Global Lipids Genetics Consortium (GLGC; up to 188,577 European individuals) were used to proxy inhibition of …
METHODS: Single-nucleotide polymorphisms (SNPs) in HMGCR, NPC1L1, and PCSK9 associated with LDL-C in a genome-wide association study …
NPC1L1 Plays a Novel Role in Nonalcoholic Fatty Liver Disease.
Xu C, Fu F, She Y, Xu C. Xu C, et al. ACS Omega. 2023 Dec 13;8(51):48586-48589. doi: 10.1021/acsomega.3c07337. eCollection 2023 Dec 26. ACS Omega. 2023. PMID: 38162748 Free PMC article. Review.
Niemann-Pick C1-Like 1 (NPC1L1) is a key protein in the transport of cholesterol, which exists in the brush marginal membrane of the intestinal epithelial cells and the timid duct membrane of the liver. ...NASH can progress to fibrosis and cirrhosis, with serious consequen …
Niemann-Pick C1-Like 1 (NPC1L1) is a key protein in the transport of cholesterol, which exists in the brush marginal membrane of the …
NPC1L1 and cholesterol transport.
Betters JL, Yu L. Betters JL, et al. FEBS Lett. 2010 Jul 2;584(13):2740-7. doi: 10.1016/j.febslet.2010.03.030. Epub 2010 Mar 19. FEBS Lett. 2010. PMID: 20307540 Free PMC article. Review.
It is essential for intestinal sterol absorption and is the molecular target of ezetimibe, a potent cholesterol absorption inhibitor that lowers blood cholesterol in humans. NPC1L1 is also highly expressed in human liver. The hepatic function of NPC1L1 may be to lim …
It is essential for intestinal sterol absorption and is the molecular target of ezetimibe, a potent cholesterol absorption inhibitor that lo …
Recent advances in the screening methods of NPC1L1 inhibitors.
Zhang R, Liu W, Zeng J, Meng J, Shi L, Yang S, Chang J, Wang C, Xing K, Wen J, Liu N, Liang B, Xing D. Zhang R, et al. Biomed Pharmacother. 2022 Nov;155:113732. doi: 10.1016/j.biopha.2022.113732. Epub 2022 Sep 24. Biomed Pharmacother. 2022. PMID: 36166964 Free article. Review.
NPC1L1 is a crucial protein involved in sterol lipid absorption and has been shown to play an important role in intestinal cholesterol absorption. Hypercholesterolemia is a significant risk factor for cardiovascular diseases such as coronary heart disease. Screening of …
NPC1L1 is a crucial protein involved in sterol lipid absorption and has been shown to play an important role in intestinal cholestero …
NPC1L1: evolution from pharmacological target to physiological sterol transporter.
Huff MW, Pollex RL, Hegele RA. Huff MW, et al. Arterioscler Thromb Vasc Biol. 2006 Nov;26(11):2433-8. doi: 10.1161/01.ATV.0000245791.53245.ee. Epub 2006 Sep 14. Arterioscler Thromb Vasc Biol. 2006. PMID: 16973966 Review.
Since its discovery, NPC1L1 has also been shown to play a focal physiological role in intestinal absorption of sterols, including plant sterols and cholesterol. ...The example of NPC1L1 shows how the elucidation of a pharmacological target can serve as a means to ga …
Since its discovery, NPC1L1 has also been shown to play a focal physiological role in intestinal absorption of sterols, including pla …
Lactobacillus mediates the expression of NPC1L1, CYP7A1, and ABCG5 genes to regulate cholesterol.
Cao K, Zhang K, Ma M, Ma J, Tian J, Jin Y. Cao K, et al. Food Sci Nutr. 2021 Sep 30;9(12):6882-6891. doi: 10.1002/fsn3.2600. eCollection 2021 Dec. Food Sci Nutr. 2021. PMID: 34925816 Free PMC article. Review.
This article reviews the biological effects and mechanisms of lactobacillus that mediate the expression of NPC1L1, CYP7A1, ABCG5, ABCG8, and other genes to inhibit cholesterol absorption, and discusses the mechanism of reducing cholesterol by lactobacillus in cells in vitr …
This article reviews the biological effects and mechanisms of lactobacillus that mediate the expression of NPC1L1, CYP7A1, ABCG5, ABC …
FGF15 promotes hepatic NPC1L1 degradation in lithogenic diet-fed mice.
Mo P, Chen H, Jiang X, Hu F, Zhang F, Shan G, Chen W, Li S, Li Y, Xu G. Mo P, et al. Lipids Health Dis. 2022 Oct 8;21(1):97. doi: 10.1186/s12944-022-01709-8. Lipids Health Dis. 2022. PMID: 36209166 Free PMC article.
Ezetimibe (EZE) can inhibit both hepatic and intestinal NPC1L1. However, whether hepatic NPC1L1 can affect CGD progress remains unknown. METHODS: Mice expressing hepatic NPC1L1 (NPC1L1(hepatic-OE) mice) were generated using Adeno-associated viruses (AA …
Ezetimibe (EZE) can inhibit both hepatic and intestinal NPC1L1. However, whether hepatic NPC1L1 can affect CGD progress remain …
754 results