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NPFFR2-deficient mice fed a high-fat diet develop strong intolerance to glucose.
Karnošová A, Strnadová V, Železná B, Kuneš J, Kašpárek P, Maletínská L. Karnošová A, et al. Clin Sci (Lond). 2023 May 31;137(10):847-862. doi: 10.1042/CS20220880. Clin Sci (Lond). 2023. PMID: 37191311 Free PMC article.
A previous study on neuropeptide FF receptor 2 (NPFFR2)-deficient mice has demonstrated that NPFFR2 is involved in the control of energy balance and thermogenesis. ...HFD feeding did not cause liver steatosis in NPFFR2 KO mice of either sex, but NPFFR2 …
A previous study on neuropeptide FF receptor 2 (NPFFR2)-deficient mice has demonstrated that NPFFR2 is involved in the control …
NPFFR2 Contributes to the Malignancy of Hepatocellular Carcinoma Development by Activating RhoA/YAP Signaling.
Shin Y, Jung W, Kim MY, Shin D, Kim GH, Kim CH, Park SH, Cho EH, Choi DW, Han CJ, Lee KH, Kim SB, Shin HJ. Shin Y, et al. Cancers (Basel). 2022 Nov 27;14(23):5850. doi: 10.3390/cancers14235850. Cancers (Basel). 2022. PMID: 36497331 Free PMC article.
Moreover, we found that the malignant function of NPFFR2 depends on RhoA and YAP signaling. Inhibition of Rho kinase activity completely restored the phenotypes induced by NPFFR2, and RhoA/F-Actin/YAP signaling was controlled by NPFFR2. These findings demonst …
Moreover, we found that the malignant function of NPFFR2 depends on RhoA and YAP signaling. Inhibition of Rho kinase activity complet …
Knockout of NPFFR2 Prevents LPS-Induced Depressive-Like Responses in Mice.
Yu Z, Lin YT, Chen JC. Yu Z, et al. Int J Mol Sci. 2021 Jul 16;22(14):7611. doi: 10.3390/ijms22147611. Int J Mol Sci. 2021. PMID: 34299230 Free PMC article.
Moreover, we previously demonstrated that neuropeptide FF receptor 2 (NPFFR2) overexpression provokes depressive-like behaviors in mice. ...Taken together, these results suggest that NPFFR2 modulates LPS-induced depressive-like behavioral phenotypes by downregulatin …
Moreover, we previously demonstrated that neuropeptide FF receptor 2 (NPFFR2) overexpression provokes depressive-like behaviors in mi …
NPFFR2 gene compound heterozygous variants associated with preeclampsia identified by whole-exome sequencing.
Jiang H, Wang L, Zhu J, Ping Z. Jiang H, et al. Gene. 2023 Feb 20;854:147108. doi: 10.1016/j.gene.2022.147108. Epub 2022 Dec 16. Gene. 2023. PMID: 36535464 Free article.
RESULTS: After a rigorous bioinformatics analysis, compound heterozygous variants in the NPFFR2 gene, NM_004885.2: c.601A > G, p.Met201Val and c.995C > T, p.Ala332Val were found in the No.4 pedigree. ...CONCLUSIONS: We demonstrated for the first time that compound he …
RESULTS: After a rigorous bioinformatics analysis, compound heterozygous variants in the NPFFR2 gene, NM_004885.2: c.601A > G, p.M …
NPFFR2 Activates the HPA Axis and Induces Anxiogenic Effects in Rodents.
Lin YT, Yu YL, Hong WC, Yeh TS, Chen TC, Chen JC. Lin YT, et al. Int J Mol Sci. 2017 Aug 21;18(8):1810. doi: 10.3390/ijms18081810. Int J Mol Sci. 2017. PMID: 28825666 Free PMC article.
However, little is known about the action of NPFF on HPA axis activity and anxiety-like behaviors, and the role of the individual receptors remains unclear. In this study, NPFFR2 agonists were used to examine the role of NPFFR2 in activating the HPA axis in rodents. …
However, little is known about the action of NPFF on HPA axis activity and anxiety-like behaviors, and the role of the individual receptors …
Ablation of NPFFR2 in Mice Reduces Response to Single Prolonged Stress Model.
Lin YT, Huang YL, Tsai SC, Chen JC. Lin YT, et al. Cells. 2020 Nov 14;9(11):2479. doi: 10.3390/cells9112479. Cells. 2020. PMID: 33202667 Free PMC article.
In this study, we further examined the role of NPFFR2 in stress response in mice by utilizing a single prolonged stress (SPS). ...The NPFFR2 knockouts showed resistance to stress exposure-induced anxiety-like behaviors and HPA axis hyperactivity. ...
In this study, we further examined the role of NPFFR2 in stress response in mice by utilizing a single prolonged stress (SPS). ...The …
Activation of NPFFR2 leads to hyperalgesia through the spinal inflammatory mediator CGRP in mice.
Lin YT, Liu HL, Day YJ, Chang CC, Hsu PH, Chen JC. Lin YT, et al. Exp Neurol. 2017 May;291:62-73. doi: 10.1016/j.expneurol.2017.02.003. Epub 2017 Feb 5. Exp Neurol. 2017. PMID: 28179153
Neuropeptide FF (NPFF) is recognized as an opioid modulating peptide that regulates morphine-induced analgesia. The aim of this study was to delineate the role of NPFFR2 in pain transmission. We found the expression levels of NPFF and NPFFR2 were increased in the lu …
Neuropeptide FF (NPFF) is recognized as an opioid modulating peptide that regulates morphine-induced analgesia. The aim of this study was to …
Chronic activation of NPFFR2 stimulates the stress-related depressive behaviors through HPA axis modulation.
Lin YT, Liu TY, Yang CY, Yu YL, Chen TC, Day YJ, Chang CC, Huang GJ, Chen JC. Lin YT, et al. Psychoneuroendocrinology. 2016 Sep;71:73-85. doi: 10.1016/j.psyneuen.2016.05.014. Epub 2016 May 18. Psychoneuroendocrinology. 2016. PMID: 27243477
Neuropeptide FF (NPFF) is a morphine-modulating peptide that regulates the analgesic effect of opioids, and also controls food consumption and cardiovascular function through its interaction with two cognate receptors, NPFFR1 and NPFFR2. In the present study, we explore a …
Neuropeptide FF (NPFF) is a morphine-modulating peptide that regulates the analgesic effect of opioids, and also controls food consumption a …
Hypothalamic NPFFR2 attenuates central insulin signaling and its knockout diminishes metabolic dysfunction in mouse models of diabetes mellitus.
Lin YT, Wu KH, Jhang JJ, Jhang JL, Yu Z, Tsai SC, Chen JC, Hsu PH, Li HY. Lin YT, et al. Clin Nutr. 2024 Mar;43(3):603-619. doi: 10.1016/j.clnu.2024.01.013. Epub 2024 Jan 18. Clin Nutr. 2024. PMID: 38301284
The impacts of central NPFFR2 were demonstrated specifically through Npffr2 overexpression in the hypothalamic arcuate nucleus, which subsequently induced type 2 diabetes. RESULTS: We found that stimulating NPFFR2 in the hypothalamus blocked hypothalamic insu …
The impacts of central NPFFR2 were demonstrated specifically through Npffr2 overexpression in the hypothalamic arcuate nucleus …
NPFF stimulates human ovarian cancer cell invasion by upregulating MMP-9 via ERK1/2 signaling.
Wu Z, Jia Q, Liu B, Fang L, Leung PCK, Cheng JC. Wu Z, et al. Exp Cell Res. 2023 Sep 1;430(1):113693. doi: 10.1016/j.yexcr.2023.113693. Epub 2023 Jun 29. Exp Cell Res. 2023. PMID: 37392963
The TaqMan probe-based RT-qPCR showed that NPFF and NPFFR2 were expressed in three human EOC cells, CaOV3, OVCAR3, and SKOV3. In comparison, NPFF and NPFFR2 expression levels were higher in SKOV3 cells than in CaOV3 or OVCAR3 cells. ...
The TaqMan probe-based RT-qPCR showed that NPFF and NPFFR2 were expressed in three human EOC cells, CaOV3, OVCAR3, and SKOV3. In comp …
74 results