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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1975 1
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1982 5
1983 3
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1986 2
1987 6
1988 2
1989 4
1990 2
1991 1
1992 3
1994 1
1995 3
1996 1
1997 1
1998 3
1999 2
2000 6
2001 4
2002 2
2003 5
2004 1
2005 4
2006 5
2007 6
2008 3
2009 4
2010 4
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2012 9
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2015 15
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2020 31
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2023 29
2024 5

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318 results

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Page 1
Nppc/Npr2/cGMP signaling cascade maintains oocyte developmental capacity.
Celik O, Celik N, Ugur K, Hatirnaz S, Celik S, Muderris II, Yavuzkir S, Sahin İ, Yardim M, Aydin S. Celik O, et al. Cell Mol Biol (Noisy-le-grand). 2019 Apr 30;65(4):83-89. Cell Mol Biol (Noisy-le-grand). 2019. PMID: 31078160 Review.
While Nppc is expressed in mural cells, cumulus cells express Npr2. Nppc/Npr2 system exerts its biological function on developing follicles by increasing the production of intracellular cyclic guanosine monophosphate (cGMP). ...Disorganized chromosomes, abnormal cum …
While Nppc is expressed in mural cells, cumulus cells express Npr2. Nppc/Npr2 system exerts its biological function on develop …
New developments in the genetic diagnosis of short stature.
Jee YH, Baron J, Nilsson O. Jee YH, et al. Curr Opin Pediatr. 2018 Aug;30(4):541-547. doi: 10.1097/MOP.0000000000000653. Curr Opin Pediatr. 2018. PMID: 29787394 Free PMC article. Review.
RECENT FINDINGS: In addition to SHOX deficiency which is one of the most common causes of isolated short stature, PAPPA2, ACAN, NPPC, NPR2, PTPN11 (and other rasopathies), FBN1, IHH and BMP2 have been identified in isolated growth disorders with or without other mild skele …
RECENT FINDINGS: In addition to SHOX deficiency which is one of the most common causes of isolated short stature, PAPPA2, ACAN, NPPC, …
A novel variant of NPPC causes abnormal post-translational cleavage: A candidate gene for premature ovarian insufficiency.
Park JY, Go M, Lyu SW, Yoon TK, Kang KM, Kim JW, Shim SH. Park JY, et al. Maturitas. 2022 Mar;157:40-48. doi: 10.1016/j.maturitas.2021.09.008. Epub 2021 Oct 30. Maturitas. 2022. PMID: 35120671
RESULTS: The wild-type NPPC and mutant NPPC (NPPC(131A>)(G)) were expressed in HeLa cells, and cells expressing NPPC(131A>)(G) secreted unique peptides. ...We therefore suggest that a mutation of the NPPC gene is involved in the pathogenes …
RESULTS: The wild-type NPPC and mutant NPPC (NPPC(131A>)(G)) were expressed in HeLa cells, and cells expressing N …
Signaling mechanisms and their regulation during in vivo or in vitro maturation of mammalian oocytes.
Strączyńska P, Papis K, Morawiec E, Czerwiński M, Gajewski Z, Olejek A, Bednarska-Czerwińska A. Strączyńska P, et al. Reprod Biol Endocrinol. 2022 Feb 24;20(1):37. doi: 10.1186/s12958-022-00906-5. Reprod Biol Endocrinol. 2022. PMID: 35209923 Free PMC article. Review.
This level is maintained by the activity of C-type natriuretic peptide (CNP, NPPC) produced by granulosa cells. The CNP binds to the NPR2 receptor in cumulus cells and is responsible for the production of cyclic guanosine monophosphate (cGMP). ...
This level is maintained by the activity of C-type natriuretic peptide (CNP, NPPC) produced by granulosa cells. The CNP binds to the …
Mutations in C-natriuretic peptide (NPPC): a novel cause of autosomal dominant short stature.
Hisado-Oliva A, Ruzafa-Martin A, Sentchordi L, Funari MFA, Bezanilla-López C, Alonso-Bernáldez M, Barraza-García J, Rodriguez-Zabala M, Lerario AM, Benito-Sanz S, Aza-Carmona M, Campos-Barros A, Jorge AAL, Heath KE. Hisado-Oliva A, et al. Genet Med. 2018 Jan;20(1):91-97. doi: 10.1038/gim.2017.66. Epub 2017 Jun 28. Genet Med. 2018. PMID: 28661490 Free article.
Interestingly, one has been previously linked to skeletal abnormalities in the spontaneous Nppc mouse long-bone abnormality (lbab) mutant.ConclusionsOur results demonstrate, for the first time, that NPPC mutations cause autosomal dominant short stature in humans. Th …
Interestingly, one has been previously linked to skeletal abnormalities in the spontaneous Nppc mouse long-bone abnormality (lbab) mu …
The Mature COC Promotes the Ampullary NPPC Required for Sperm Release from Porcine Oviduct Cells.
Wu Z, Li B, Yu K, Zheng N, Yuan F, Miao J, Zhang M, Wang Z. Wu Z, et al. Int J Mol Sci. 2023 Feb 4;24(4):3118. doi: 10.3390/ijms24043118. Int J Mol Sci. 2023. PMID: 36834527 Free PMC article.
NPPC increased sperm motility and intracellular Ca(2+) levels, and induced sperm release from oviduct isthmic cell aggregates. ...Taken together, the mature COCs promote NPPC expression in the ampullae via TGF-beta signaling, and NPPC is required for the rele …
NPPC increased sperm motility and intracellular Ca(2+) levels, and induced sperm release from oviduct isthmic cell aggregates. ...Tak …
The mRNA-destabilizing protein Tristetraprolin targets "meiosis arrester" Nppc mRNA in mammalian preovulatory follicles.
Xi G, An L, Wang W, Hao J, Yang Q, Ma L, Lu J, Wang Y, Wang W, Zhao W, Liu J, Yang M, Wang X, Zhang Z, Zhang C, Chu M, Yue Y, Yao F, Zhang M, Tian J. Xi G, et al. Proc Natl Acad Sci U S A. 2021 Jun 1;118(22):e2018345118. doi: 10.1073/pnas.2018345118. Proc Natl Acad Sci U S A. 2021. PMID: 34031239 Free PMC article.
In preovulatory ovarian follicles, the luteinizing hormone (LH)-induced decrease in CNP and its encoding messenger RNA (mRNA) natriuretic peptide precursor C (Nppc) are a prerequisite for oocyte meiotic resumption. However, it has never been determined how LH decreases CNP …
In preovulatory ovarian follicles, the luteinizing hormone (LH)-induced decrease in CNP and its encoding messenger RNA (mRNA) natriuretic pe …
NPPC/NPR2 signaling is essential for oocyte meiotic arrest and cumulus oophorus formation during follicular development in the mouse ovary.
Kiyosu C, Tsuji T, Yamada K, Kajita S, Kunieda T. Kiyosu C, et al. Reproduction. 2012 Aug;144(2):187-93. doi: 10.1530/REP-12-0050. Epub 2012 Jun 13. Reproduction. 2012. PMID: 22696190
However, the overall role of NPPC/NPR2 signaling in female reproduction and ovarian function is still less clear. Here we report the defects observed in oocytes and follicles of mice homozygous for Nppc(lbab) or Npr2(cn), mutant alleles of Nppc or Npr2 respec …
However, the overall role of NPPC/NPR2 signaling in female reproduction and ovarian function is still less clear. Here we report the …
De novo 2q36.3q37.1 deletion encompassing TRIP12 and NPPC yields distinct phenotypes.
Kondo Y, Aoyama K, Suzuki H, Hattori A, Hori I, Ito K, Yoshida A, Koroki M, Ueda K, Kosaki K, Saitoh S. Kondo Y, et al. Hum Genome Var. 2020 Jun 1;7:19. doi: 10.1038/s41439-020-0107-1. eCollection 2020. Hum Genome Var. 2020. PMID: 32528716 Free PMC article.
We report a patient with developmental delay, extremely short stature, small hands, dysmorphic facial features, hearing loss, and epilepsy carrying a de novo 2.76-Mb deletion of 2q36.3q37.1, including TRIP12 and NPPC. TRIP12 haploinsufficiency causes developmental delay wi …
We report a patient with developmental delay, extremely short stature, small hands, dysmorphic facial features, hearing loss, and epilepsy c …
Granulosa cell ligand NPPC and its receptor NPR2 maintain meiotic arrest in mouse oocytes.
Zhang M, Su YQ, Sugiura K, Xia G, Eppig JJ. Zhang M, et al. Science. 2010 Oct 15;330(6002):366-9. doi: 10.1126/science.1193573. Science. 2010. PMID: 20947764 Free PMC article.
We show that mouse mural granulosa cells, which line the follicle wall, express natriuretic peptide precursor type C (Nppc) messenger RNA (mRNA), whereas cumulus cells surrounding oocytes express mRNA of the NPPC receptor NPR2, a guanylyl cyclase. NPPC increa …
We show that mouse mural granulosa cells, which line the follicle wall, express natriuretic peptide precursor type C (Nppc) messenger …
318 results