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2006 3
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198 results

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NSUN2 is a glucose sensor suppressing cGAS/STING to maintain tumorigenesis and immunotherapy resistance.
Chen T, Xu ZG, Luo J, Manne RK, Wang Z, Hsu CC, Pan BS, Cai Z, Tsai PJ, Tsai YS, Chen ZZ, Li HY, Lin HK. Chen T, et al. Cell Metab. 2023 Oct 3;35(10):1782-1798.e8. doi: 10.1016/j.cmet.2023.07.009. Epub 2023 Aug 15. Cell Metab. 2023. PMID: 37586363
Here, we report that glucose is a cofactor binding to methyltransferase NSUN2 at amino acid 1-28 to promote NSUN2 oligomerization and activation. ...An NSUN2 mutant defective in glucose binding or disrupting glucose/NSUN2 interaction abolishes NSUN2 …
Here, we report that glucose is a cofactor binding to methyltransferase NSUN2 at amino acid 1-28 to promote NSUN2 oligomerizat …
Aberrant m5C hypermethylation mediates intrinsic resistance to gefitinib through NSUN2/YBX1/QSOX1 axis in EGFR-mutant non-small-cell lung cancer.
Wang Y, Wei J, Feng L, Li O, Huang L, Zhou S, Xu Y, An K, Zhang Y, Chen R, He L, Wang Q, Wang H, Du Y, Liu R, Huang C, Zhang X, Yang YG, Kan Q, Tian X. Wang Y, et al. Mol Cancer. 2023 May 9;22(1):81. doi: 10.1186/s12943-023-01780-4. Mol Cancer. 2023. PMID: 37161388 Free PMC article.
RESULTS: RNA m(5)C hypermethylation and NSUN2 were significantly correlated with intrinsic resistance to EGFR-TKIs. Overexpression of NSUN2 resulted in gefitinib resistance and tumor recurrence, while genetic inhibition of NSUN2 led to tumor regression and ov …
RESULTS: RNA m(5)C hypermethylation and NSUN2 were significantly correlated with intrinsic resistance to EGFR-TKIs. Overexpression of …
NSUN2 modified by SUMO-2/3 promotes gastric cancer progression and regulates mRNA m5C methylation.
Hu Y, Chen C, Tong X, Chen S, Hu X, Pan B, Sun X, Chen Z, Shi X, Hu Y, Shen X, Xue X, Lu M. Hu Y, et al. Cell Death Dis. 2021 Sep 9;12(9):842. doi: 10.1038/s41419-021-04127-3. Cell Death Dis. 2021. PMID: 34504059 Free PMC article.
However, the biological significance of NSUN2 in gastric cancer (GC) and the modification of NSUN2 itself have not been fully investigated. ...NSUN2 was upregulated in GC, and that it was a predictor of poor prognosis. ...
However, the biological significance of NSUN2 in gastric cancer (GC) and the modification of NSUN2 itself have not been fully …
NSUN2-mediated RNA 5-methylcytosine promotes esophageal squamous cell carcinoma progression via LIN28B-dependent GRB2 mRNA stabilization.
Su J, Wu G, Ye Y, Zhang J, Zeng L, Huang X, Zheng Y, Bai R, Zhuang L, Li M, Pan L, Deng J, Li R, Deng S, Zhang S, Zuo Z, Liu Z, Lin J, Lin D, Zheng J. Su J, et al. Oncogene. 2021 Sep;40(39):5814-5828. doi: 10.1038/s41388-021-01978-0. Epub 2021 Aug 3. Oncogene. 2021. PMID: 34345012 Free PMC article.
Here, by detecting the transcriptome-wide m(5)C profiling in esophageal squamous cell carcinoma (ESCC), we showed increased m(5)C methylation in ESCC tumors due to the overexpressed m(5)C methyltransferase NSUN2. Aberrant expression of NSUN2 was positively regulated …
Here, by detecting the transcriptome-wide m(5)C profiling in esophageal squamous cell carcinoma (ESCC), we showed increased m(5)C methylatio …
NSUN2 promotes osteosarcoma progression by enhancing the stability of FABP5 mRNA via m(5)C methylation.
Yang M, Wei R, Zhang S, Hu S, Liang X, Yang Z, Zhang C, Zhang Y, Cai L, Xie Y. Yang M, et al. Cell Death Dis. 2023 Feb 15;14(2):125. doi: 10.1038/s41419-023-05646-x. Cell Death Dis. 2023. PMID: 36792587 Free PMC article.
However, the functions and underlying molecular mechanisms of NSUN2-mediated m(5)C in osteosarcoma (OS) remain unclear. In this study, we found NSUN2 was highly expressed in OS tissues and cells. We also discovered that higher expression of NSUN2 predicted po …
However, the functions and underlying molecular mechanisms of NSUN2-mediated m(5)C in osteosarcoma (OS) remain unclear. In this study …
NSUN2-mediated M(5)c methylation of IRF3 mRNA negatively regulates type I interferon responses during various viral infections.
Wang H, Feng J, Zeng C, Liu J, Fu Z, Wang D, Wang Y, Zhang L, Li J, Jiang A, He M, Cao Y, Yan K, Tang H, Guo D, Xu K, Zhou X, Zhou L, Lan K, Zhou Y, Chen Y. Wang H, et al. Emerg Microbes Infect. 2023 Dec;12(1):2178238. doi: 10.1080/22221751.2023.2178238. Emerg Microbes Infect. 2023. PMID: 36748584 Free PMC article.
Knockout or knockdown of NSUN2 enhanced type I interferon and downstream ISGs during various viral infection in vitro. And in vivo, the antiviral innate response is more dramatically enhanced in Nsun2(+/-) mice than in Nsun2(+/+) mice. The highly m(5)C methyl …
Knockout or knockdown of NSUN2 enhanced type I interferon and downstream ISGs during various viral infection in vitro. And in vivo, t …
NSUN2-mediated m(5) C RNA methylation dictates retinoblastoma progression through promoting PFAS mRNA stability and expression.
Zuo S, Li L, Wen X, Gu X, Zhuang A, Li R, Ye F, Ge S, Fan X, Fan J, Chai P, Lu L. Zuo S, et al. Clin Transl Med. 2023 May;13(5):e1273. doi: 10.1002/ctm2.1273. Clin Transl Med. 2023. PMID: 37228185 Free PMC article.
Organoid-based single-cell analysis and gene-correlation analysis were performed to verify the NSUN2/ALYREF/m(5) C-PFAS oncogenic cascade. RESULTS: Herein, we report that NSUN2-mediated m(5) C RNA methylation fuels purine biosynthesis during the oncogenic progressio …
Organoid-based single-cell analysis and gene-correlation analysis were performed to verify the NSUN2/ALYREF/m(5) C-PFAS oncogenic cas …
The RNA Methyltransferase NSUN2 and Its Potential Roles in Cancer.
Chellamuthu A, Gray SG. Chellamuthu A, et al. Cells. 2020 Jul 22;9(8):1758. doi: 10.3390/cells9081758. Cells. 2020. PMID: 32708015 Free PMC article. Review.
In mammalian cells, the addition of m5C to RNA cytosines is carried out by enzymes of the NOL1/NOP2/SUN domain (NSUN) family as well as the DNA methyltransferase homologue DNMT2. In this regard, NSUN2 is a critical RNA methyltransferase for adding m5C to mRNA. ...
In mammalian cells, the addition of m5C to RNA cytosines is carried out by enzymes of the NOL1/NOP2/SUN domain (NSUN) family as well as the …
NSUN2 stimulates tumor progression via enhancing TIAM2 mRNA stability in pancreatic cancer.
Zhang G, Liu L, Li J, Chen Y, Wang Y, Zhang Y, Dong Z, Xue W, Sun R, Cui G. Zhang G, et al. Cell Death Discov. 2023 Jul 1;9(1):219. doi: 10.1038/s41420-023-01521-y. Cell Death Discov. 2023. PMID: 37393317 Free PMC article.
Contrarily, overexpression of NSUN2 stimulated PC growth and metastasis. Mechanistically, m5C-sequencing (m5C-seq) and RNA-sequencing (RNA-seq) were carried out to identify downstream targets of NSUN2 and results showed that loss of NSUN2 led to decreased m5C …
Contrarily, overexpression of NSUN2 stimulated PC growth and metastasis. Mechanistically, m5C-sequencing (m5C-seq) and RNA-sequencing …
5-methylcytosine promotes mRNA export - NSUN2 as the methyltransferase and ALYREF as an m(5)C reader.
Yang X, Yang Y, Sun BF, Chen YS, Xu JW, Lai WY, Li A, Wang X, Bhattarai DP, Xiao W, Sun HY, Zhu Q, Ma HL, Adhikari S, Sun M, Hao YJ, Zhang B, Huang CM, Huang N, Jiang GB, Zhao YL, Wang HL, Sun YP, Yang YG. Yang X, et al. Cell Res. 2017 May;27(5):606-625. doi: 10.1038/cr.2017.55. Epub 2017 Apr 18. Cell Res. 2017. PMID: 28418038 Free PMC article.
NSUN2 modulates ALYREF's nuclear-cytoplasmic shuttling, RNA-binding affinity and associated mRNA export. Dysregulation of ALYREF-mediated mRNA export upon NSUN2 depletion could be restored by reconstitution of wild-type but not methyltransferase-defective NSUN2 …
NSUN2 modulates ALYREF's nuclear-cytoplasmic shuttling, RNA-binding affinity and associated mRNA export. Dysregulation of ALYREF-medi …
198 results