Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1964 1
1970 1
1972 1
1973 1
1975 3
1976 1
1977 3
1978 1
1979 2
1980 2
1981 1
1982 1
1983 1
1991 1
1998 1
2005 1
2007 1
2008 2
2010 4
2011 3
2012 4
2013 6
2014 8
2015 14
2016 11
2017 10
2018 20
2019 6
2020 18
2021 17
2022 28
2023 29
2024 10

Text availability

Article attribute

Article type

Publication date

Search Results

190 results

Results by year

Filters applied: . Clear all
Page 1
Nuciferine protects against folic acid-induced acute kidney injury by inhibiting ferroptosis.
Li D, Liu B, Fan Y, Liu M, Han B, Meng Y, Xu X, Song Z, Liu X, Hao Q, Duan X, Nakai A, Chang Y, Cao P, Tan K. Li D, et al. Br J Pharmacol. 2021 Mar;178(5):1182-1199. doi: 10.1111/bph.15364. Br J Pharmacol. 2021. PMID: 33450067 Free article.
In HK-2 and HEK293T cells, nuciferine significantly prevented RSL3-induced ferroptotic cell death. ...Nuciferine may represent a novel treatment that improves recovery from acute kidney injury by targeting ferroptosis....
In HK-2 and HEK293T cells, nuciferine significantly prevented RSL3-induced ferroptotic cell death. ...Nuciferine may represent …
Nuciferine ameliorates hepatic steatosis in high-fat diet/streptozocin-induced diabetic mice through a PPARalpha/PPARgamma coactivator-1alpha pathway.
Zhang C, Deng J, Liu D, Tuo X, Xiao L, Lai B, Yao Q, Liu J, Yang H, Wang N. Zhang C, et al. Br J Pharmacol. 2018 Nov;175(22):4218-4228. doi: 10.1111/bph.14482. Epub 2018 Oct 11. Br J Pharmacol. 2018. PMID: 30129056 Free PMC article.
BACKGROUND AND PURPOSE: Nuciferine, an alkaloid found in Nelumbo nucifera leaves, alleviates dyslipidemia in vivo. ...Hepatic levels of total cholesterol, triglycerides and LDL were decreased, as were the number of lipid droplets, by nuciferine treatment. Furthermor …
BACKGROUND AND PURPOSE: Nuciferine, an alkaloid found in Nelumbo nucifera leaves, alleviates dyslipidemia in vivo. ...Hepatic levels …
Structure-activity relationship, bioactivities, molecular mechanisms, and clinical application of nuciferine on inflammation-related diseases.
Zhao T, Zhu Y, Zhao R, Xiong S, Sun J, Zhang J, Fan D, Deng J, Yang H. Zhao T, et al. Pharmacol Res. 2023 Jul;193:106820. doi: 10.1016/j.phrs.2023.106820. Epub 2023 Jun 12. Pharmacol Res. 2023. PMID: 37315822 Free article. Review.
However, no review has summarized the anti-inflammatory effect of nuciferine. This review critically summarized the information regarding the structure-activity relationships of dietary nuciferine. ...The current work provides a better understanding of the anti-infl …
However, no review has summarized the anti-inflammatory effect of nuciferine. This review critically summarized the information regar …
Nuciferine protects against high-fat diet-induced hepatic steatosis and insulin resistance via activating TFEB-mediated autophagy-lysosomal pathway.
Du X, Di Malta C, Fang Z, Shen T, Niu X, Chen M, Jin B, Yu H, Lei L, Gao W, Song Y, Wang Z, Xu C, Cao Z, Liu G, Li X. Du X, et al. Acta Pharm Sin B. 2022 Jun;12(6):2869-2886. doi: 10.1016/j.apsb.2021.12.012. Epub 2021 Dec 22. Acta Pharm Sin B. 2022. PMID: 35755273 Free PMC article.
The objective of this study was to investigate the effects of nuciferine, a major active component from lotus leaf, on NAFLD and its underlying mechanism of action. Here we show that nuciferine activated ALP and alleviated steatosis, insulin resistance in the livers …
The objective of this study was to investigate the effects of nuciferine, a major active component from lotus leaf, on NAFLD and its …
Nuciferine Protects against Obesity-Induced Nephrotoxicity through Its Hypolipidemic, Anti-Inflammatory, and Antioxidant Effects.
Zhu X, Si F, Hao R, Zheng J, Zhang C. Zhu X, et al. J Agric Food Chem. 2023 Dec 6;71(48):18769-18779. doi: 10.1021/acs.jafc.3c05735. Epub 2023 Nov 25. J Agric Food Chem. 2023. PMID: 38006352
Nuciferine also effectively attenuated HFD-induced renal lipid accumulation via the AMPK-mediated regulation of FAS and HSL expressions and suppressed inflammation and oxidative stress via the AMPK-mediated Nrf-2/HO-1 and TLR4/MyD88/NF-kappaB pathways. ...Therefore, nuc …
Nuciferine also effectively attenuated HFD-induced renal lipid accumulation via the AMPK-mediated regulation of FAS and HSL expressio …
Nuciferine improves random skin flap survival via TFEB-mediated activation of autophagy-lysosomal pathway.
Xue K, Zhang G, Zhou Y, Wang K, Yao Z, Chen J, Zhang Y, Li Z, Li Z, Zheng Z, Feng Y, Mao C, Lin C, Xia W. Xue K, et al. Int Immunopharmacol. 2023 Jun;119:110204. doi: 10.1016/j.intimp.2023.110204. Epub 2023 Apr 29. Int Immunopharmacol. 2023. PMID: 37126988
However, the post-operative necrosis frequently happens because of the ischemia and high-level of oxidative stress of random skin flaps, which can severely affect the healing outcomes. Earlier evidence has shown promising effect of Nuciferine (NF) on preventing hydrogen pe …
However, the post-operative necrosis frequently happens because of the ischemia and high-level of oxidative stress of random skin flaps, whi …
1-(2'-Bromobenzyl)-6,7-dihydroxy-N-methyl-tetrahydroisoquinoline and 1,2-Demethyl-nuciferine as Agonists in Human D(2) Dopamine Receptors.
Silva AG, Vila L, Marques P, Moreno L, Loza M, Sanz MJ, Cortes D, Castro M, Cabedo N. Silva AG, et al. J Nat Prod. 2020 Jan 24;83(1):127-133. doi: 10.1021/acs.jnatprod.9b00921. Epub 2020 Jan 14. J Nat Prod. 2020. PMID: 31933369
Two isoquinoline derivatives, 1-(2'-bromobenzyl)-6,7-dihydroxy-N-methyl-tetrahydroisoquinoline (Br-BTHIQ, 1) and 1,2-demethyl-nuciferine (aporphine, 2), were herein synthesized, and their dopaminergic affinity in cloned human D(2)R, D(3)R, and D(4)R subtypes and their beha …
Two isoquinoline derivatives, 1-(2'-bromobenzyl)-6,7-dihydroxy-N-methyl-tetrahydroisoquinoline (Br-BTHIQ, 1) and 1,2-demethyl-nuciferine …
Nuciferine Protects Against High-Fat Diet-Induced Hepatic Steatosis via Modulation of Gut Microbiota and Bile Acid Metabolism in Rats.
Sun J, Fan J, Li T, Yan X, Jiang Y. Sun J, et al. J Agric Food Chem. 2022 Sep 28;70(38):12014-12028. doi: 10.1021/acs.jafc.2c04817. Epub 2022 Sep 15. J Agric Food Chem. 2022. PMID: 36106619
Our previous study showed that nuciferine (NF) attenuated non-alcoholic fatty liver disease (NAFLD), which is attributed to a high-fat diet (HFD) through reinforcing intestinal barrier functions, regulating lipid metabolism, and improving inflammation. ...
Our previous study showed that nuciferine (NF) attenuated non-alcoholic fatty liver disease (NAFLD), which is attributed to a high-fa …
Nuciferine attenuates lipopolysaccharide-stimulated inflammatory responses by inhibiting p38 MAPK/ATF2 signaling pathways.
Kim SM, Park EJ, Lee HJ. Kim SM, et al. Inflammopharmacology. 2022 Dec;30(6):2373-2383. doi: 10.1007/s10787-022-01075-y. Epub 2022 Oct 11. Inflammopharmacology. 2022. PMID: 36219321
However, little is known about the mechanism of nuciferine action on the inflammatory response. This study aimed to investigate the anti-inflammatory effects of nuciferine and its underlying molecular mechanisms in lipopolysaccharide (LPS)-stimulated murine macropha …
However, little is known about the mechanism of nuciferine action on the inflammatory response. This study aimed to investigate the a …
Preventive Effect of Nuciferine on H(2)O(2)-Induced Fibroblast Senescence and Pro-Inflammatory Cytokine Gene Expression.
Charoensin S, Weera W. Charoensin S, et al. Molecules. 2022 Nov 23;27(23):8148. doi: 10.3390/molecules27238148. Molecules. 2022. PMID: 36500241 Free PMC article.
We found that H(2)O(2) treatment resulted in a significant increase in senescence-associated beta-galactosidase (SA-beta-gal)-positive cells. Nuciferine-treated cells, however, showed a reduction in senescent phenotype. ...The mRNA levels of CXCL1, CXCL2, IL-6, and IL-8 (p …
We found that H(2)O(2) treatment resulted in a significant increase in senescence-associated beta-galactosidase (SA-beta-gal)-positive cells …
190 results