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Paralogous murine Nudt10 and Nudt11 genes have differential expression patterns but encode identical proteins that are physiologically competent diphosphoinositol polyphosphate phosphohydrolases.
Hua LV, Hidaka K, Pesesse X, Barnes LD, Shears SB. Hua LV, et al. Biochem J. 2003 Jul 1;373(Pt 1):81-9. doi: 10.1042/BJ20030142. Biochem J. 2003. PMID: 12689335 Free PMC article.
One possible functional consequence is gene neofunctionalization, but we exclude that, since Nudt10 and Nudt11 encode identical proteins. Another possibility is gene subfunctionalization, which we studied by conducting the first quantitative expression analysis of these ge …
One possible functional consequence is gene neofunctionalization, but we exclude that, since Nudt10 and Nudt11 encode identical prote …
Clinical correlations and prognostic value of Nudix hydroxylase 10 in patients with gastric cancer.
Chen D, Zhang R, Xie A, Yuan J, Zhang J, Huang Y, Zhang H, Zhang F. Chen D, et al. Bioengineered. 2021 Dec;12(2):9779-9789. doi: 10.1080/21655979.2021.1995104. Bioengineered. 2021. PMID: 34696672 Free PMC article. Clinical Trial.
Patients with higher NUDT10 expression had a significantly worse prognosis than those with lower NUDT10 expression. ...To our knowledge, this study is the first to characterize NUDT10 expression in GC. Our study demonstrates that NUDT10 is a promising …
Patients with higher NUDT10 expression had a significantly worse prognosis than those with lower NUDT10 expression. ...To our …
NUDT11 rs5945572 polymorphism and prostate cancer risk: a meta-analysis.
Li W, Gu M. Li W, et al. Int J Clin Exp Med. 2015 Mar 15;8(3):3474-81. eCollection 2015. Int J Clin Exp Med. 2015. PMID: 26064238 Free PMC article.
The association between the NUDT10 rs5945572 polymorphism and prostate cancer (PCa) was not clear. We thus conducted a meta-analysis to assess the association between NUDT10 rs5945572 polymorphism and PCa risk. ...In conclusion, this meta-analysis found a significan …
The association between the NUDT10 rs5945572 polymorphism and prostate cancer (PCa) was not clear. We thus conducted a meta-analysis …
A signature of five 7-methylguanosine-related genes is a prognostic marker for lung squamous cell carcinoma.
Liu W, Wang Y, Ulivi P, Tavolari S, Rizvi SAA, Capobianco E, Navarro A, Zhang Y. Liu W, et al. J Thorac Dis. 2023 Nov 30;15(11):6265-6278. doi: 10.21037/jtd-23-1504. Epub 2023 Nov 27. J Thorac Dis. 2023. PMID: 38090319 Free PMC article.
The expression of five m7G-related genes (EIF3D, LSM1, NCBP2, NUDT10, and NUDT11) was identified as an independent prognostic marker for OS in LSCC patients. ...
The expression of five m7G-related genes (EIF3D, LSM1, NCBP2, NUDT10, and NUDT11) was identified as an independent prognostic marker …
Exploring targets of TET2-mediated methylation reprogramming as potential discriminators of prostate cancer progression.
Kamdar S, Isserlin R, Van der Kwast T, Zlotta AR, Bader GD, Fleshner NE, Bapat B. Kamdar S, et al. Clin Epigenetics. 2019 Mar 27;11(1):54. doi: 10.1186/s13148-019-0651-z. Clin Epigenetics. 2019. PMID: 30917865 Free PMC article.
RESULTS: Using a CRISPR/Cas9-derived TET2-knockout prostate cell line, and through whole-transcriptome and whole-methylome sequencing, we identified seven candidate genes-ASB2, ETNK2, MEIS2, NRG1, NTN1, NUDT10, and SRPX-exhibiting reduced expression and increased promoter …
RESULTS: Using a CRISPR/Cas9-derived TET2-knockout prostate cell line, and through whole-transcriptome and whole-methylome sequencing, we id …
Validation of genome-wide prostate cancer associations in men of African descent.
Chang BL, Spangler E, Gallagher S, Haiman CA, Henderson B, Isaacs W, Benford ML, Kidd LR, Cooney K, Strom S, Ingles SA, Stern MC, Corral R, Joshi AD, Xu J, Giri VN, Rybicki B, Neslund-Dudas C, Kibel AS, Thompson IM, Leach RJ, Ostrander EA, Stanford JL, Witte J, Casey G, Eeles R, Hsing AW, Chanock S, Hu JJ, John EM, Park J, Stefflova K, Zeigler-Johnson C, Rebbeck TR. Chang BL, et al. Cancer Epidemiol Biomarkers Prev. 2011 Jan;20(1):23-32. doi: 10.1158/1055-9965.EPI-10-0698. Epub 2010 Nov 11. Cancer Epidemiol Biomarkers Prev. 2011. PMID: 21071540 Free PMC article.
RESULTS: We identified significant associations for SNP rs10486567 at JAZF1, rs10993994 at MSMB, rs12418451 and rs7931342 at 11q13, and rs5945572 and rs5945619 at NUDT10/11. These associations were in the same direction and of similar magnitude as those reported in men of …
RESULTS: We identified significant associations for SNP rs10486567 at JAZF1, rs10993994 at MSMB, rs12418451 and rs7931342 at 11q13, and rs59 …
m7G Methylation-Related Genes as Biomarkers for Predicting Overall Survival Outcomes for Hepatocellular Carcinoma.
Li XY, Zhao ZJ, Wang JB, Shao YH, Hui-Liu, You JX, Yang XT. Li XY, et al. Front Bioeng Biotechnol. 2022 May 10;10:849756. doi: 10.3389/fbioe.2022.849756. eCollection 2022. Front Bioeng Biotechnol. 2022. PMID: 35620469 Free PMC article.
Results: The prognostic model was built using the seven genes, namely, CYFIP1, EIF4E2, EIF4G3, GEMIN5, NCBP2, NUDT10, and WDR4. The Kaplan-Meier survival analysis showed poorer 5-years overall survival in the high-risk group compared with the low-risk group, and the receiv …
Results: The prognostic model was built using the seven genes, namely, CYFIP1, EIF4E2, EIF4G3, GEMIN5, NCBP2, NUDT10, and WDR4. The K …
A Novel 7-Methylguanosine (m7G)-Related Gene Signature for Overall Survival Prediction in Patient with Clear Cell Renal Cell Carcinoma.
Fu Y, Wang J, Hu Z, Gou Y, Li Y, Jiang Q. Fu Y, et al. J Oncol. 2023 Apr 8;2023:9645038. doi: 10.1155/2023/9645038. eCollection 2023. J Oncol. 2023. PMID: 37089261 Free PMC article.
Based on Lasso regression analysis, five optimal genes (CYFIP2, EIF4A1, NUDT1, NUDT10, and NUDT4) were chosen to build a new predictive risk model in the TCGA cohort. ...
Based on Lasso regression analysis, five optimal genes (CYFIP2, EIF4A1, NUDT1, NUDT10, and NUDT4) were chosen to build a new predicti …
Suggestive association between variants in IL1RAPL and asthma symptoms in Latin American children.
Marques CR, Costa GN, da Silva TM, Oliveira P, Cruz AA, Alcantara-Neves NM, Fiaccone RL, Horta BL, Hartwig FP, Burchard EG, Pino-Yanes M, Rodrigues LC, Lima-Costa MF, Pereira AC, Gouveia MH, Sant Anna HP, Tarazona-Santos E, Lima Barreto M, Figueiredo CA. Marques CR, et al. Eur J Hum Genet. 2017 Apr;25(4):439-445. doi: 10.1038/ejhg.2016.197. Epub 2017 Jan 25. Eur J Hum Genet. 2017. PMID: 28120837 Free PMC article.
Furthermore, investigating the functional role of the rs12007907 on the production a Th2-type cytokine, IL-13, we found a negative association between the minor allele A with IL-13 production in the discovery set (P=0.044). Gene-based analysis revealed that NUDT10 was the …
Furthermore, investigating the functional role of the rs12007907 on the production a Th2-type cytokine, IL-13, we found a negative associati …
M7G-related molecular subtypes can predict the prognosis and correlate with immunotherapy and chemotherapy responses in bladder cancer patients.
Li DX, Feng DC, Wang XM, Wu RC, Zhu WZ, Chen K, Han P. Li DX, et al. Eur J Med Res. 2023 Feb 2;28(1):55. doi: 10.1186/s40001-023-01012-x. Eur J Med Res. 2023. PMID: 36732869 Free PMC article.
RESULTS: The m7G-related cluster was ultimately established by EIF4G1, NUDT11, NUDT10, and CCNB1. The independent prognostic value of the m7G-related cluster was validated by the TCGA and GSE13507 datasets. ...
RESULTS: The m7G-related cluster was ultimately established by EIF4G1, NUDT11, NUDT10, and CCNB1. The independent prognostic value of …
19 results