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Chronic antidepressants potentiate via sigma-1 receptors the brain-derived neurotrophic factor-induced signaling for glutamate release.
Yagasaki Y, Numakawa T, Kumamaru E, Hayashi T, Su TP, Kunugi H. Yagasaki Y, et al. Among authors: numakawa t. J Biol Chem. 2006 May 5;281(18):12941-9. doi: 10.1074/jbc.M508157200. Epub 2006 Mar 6. J Biol Chem. 2006. PMID: 16522641 Free article.
Because BDNF has been shown by us to reinforce excitatory glutamatergic transmission in cultured cortical neurons via the phospholipase-gamma (PLC-gamma)/inositol 1,4,5-trisphosphate (IP3)/Ca2+ pathway (Numakawa, T., Yamagishi, S., Adachi, N., Matsumoto, T., …
Because BDNF has been shown by us to reinforce excitatory glutamatergic transmission in cultured cortical neurons via the phospholipase-gamm …
Impact of the DISC1 Ser704Cys polymorphism on risk for major depression, brain morphology and ERK signaling.
Hashimoto R, Numakawa T, Ohnishi T, Kumamaru E, Yagasaki Y, Ishimoto T, Mori T, Nemoto K, Adachi N, Izumi A, Chiba S, Noguchi H, Suzuki T, Iwata N, Ozaki N, Taguchi T, Kamiya A, Kosuga A, Tatsumi M, Kamijima K, Weinberger DR, Sawa A, Kunugi H. Hashimoto R, et al. Among authors: numakawa t. Hum Mol Genet. 2006 Oct 15;15(20):3024-33. doi: 10.1093/hmg/ddl244. Epub 2006 Sep 7. Hum Mol Genet. 2006. PMID: 16959794
17beta-estradiol protects cortical neurons against oxidative stress-induced cell death through reduction in the activity of mitogen-activated protein kinase and in the accumulation of intracellular calcium.
Numakawa Y, Matsumoto T, Yokomaku D, Taguchi T, Niki E, Hatanaka H, Kunugi H, Numakawa T. Numakawa Y, et al. Among authors: numakawa t. Endocrinology. 2007 Feb;148(2):627-37. doi: 10.1210/en.2006-1210. Epub 2006 Nov 2. Endocrinology. 2007. PMID: 17082253
88 results