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Page 1
Synthetic Approaches to New Drugs Approved during 2018.
Flick AC, Leverett CA, Ding HX, McInturff E, Fink SJ, Helal CJ, DeForest JC, Morse PD, Mahapatra S, O'Donnell CJ. Flick AC, et al. J Med Chem. 2020 Oct 8;63(19):10652-10704. doi: 10.1021/acs.jmedchem.0c00345. Epub 2020 May 22. J Med Chem. 2020. PMID: 32338902
Synthetic approaches to the 2007 new drugs.
Liu KK, Sakya SM, O'Donnell CJ, Li J. Liu KK, et al. Mini Rev Med Chem. 2008 Dec;8(14):1526-48. doi: 10.2174/138955708786786435. Mini Rev Med Chem. 2008. PMID: 19075810 Review.
Discovery of 4-(5-methyloxazolo[4,5-b]pyridin-2-yl)-1,4-diazabicyclo[3.2.2]nonane (CP-810,123), a novel alpha 7 nicotinic acetylcholine receptor agonist for the treatment of cognitive disorders in schizophrenia: synthesis, SAR development, and in vivo efficacy in cognition models.
O'Donnell CJ, Rogers BN, Bronk BS, Bryce DK, Coe JW, Cook KK, Duplantier AJ, Evrard E, Hajós M, Hoffmann WE, Hurst RS, Maklad N, Mather RJ, McLean S, Nedza FM, O'Neill BT, Peng L, Qian W, Rottas MM, Sands SB, Schmidt AW, Shrikhande AV, Spracklin DK, Wong DF, Zhang A, Zhang L. O'Donnell CJ, et al. J Med Chem. 2010 Feb 11;53(3):1222-37. doi: 10.1021/jm9015075. J Med Chem. 2010. PMID: 20043678
Synthetic approaches to the 2008 new drugs.
Liu KK, Sakya SM, O'Donnell CJ, Li J. Liu KK, et al. Mini Rev Med Chem. 2009 Dec;9(14):1655-75. doi: 10.2174/138955709791012201. Mini Rev Med Chem. 2009. PMID: 20088782 Review.
Synthetic approaches to the 2009 new drugs.
Liu KK, Sakya SM, O'Donnell CJ, Flick AC, Li J. Liu KK, et al. Bioorg Med Chem. 2011 Feb 1;19(3):1136-54. doi: 10.1016/j.bmc.2010.12.038. Epub 2010 Dec 24. Bioorg Med Chem. 2011. PMID: 21256756 Review.
Metabolism-directed design of oxetane-containing arylsulfonamide derivatives as γ-secretase inhibitors.
Stepan AF, Karki K, McDonald WS, Dorff PH, Dutra JK, Dirico KJ, Won A, Subramanyam C, Efremov IV, O'Donnell CJ, Nolan CE, Becker SL, Pustilnik LR, Sneed B, Sun H, Lu Y, Robshaw AE, Riddell D, O'Sullivan TJ, Sibley E, Capetta S, Atchison K, Hallgren AJ, Miller E, Wood A, Obach RS. Stepan AF, et al. J Med Chem. 2011 Nov 24;54(22):7772-83. doi: 10.1021/jm200893p. Epub 2011 Oct 26. J Med Chem. 2011. PMID: 21995460
Synthetic approaches to the 2010 new drugs.
Liu KK, Sakya SM, O'Donnell CJ, Flick AC, Ding HX. Liu KK, et al. Bioorg Med Chem. 2012 Feb 1;20(3):1155-74. doi: 10.1016/j.bmc.2011.12.049. Epub 2012 Jan 2. Bioorg Med Chem. 2012. PMID: 22261026 Review.
Application of the bicyclo[1.1.1]pentane motif as a nonclassical phenyl ring bioisostere in the design of a potent and orally active γ-secretase inhibitor.
Stepan AF, Subramanyam C, Efremov IV, Dutra JK, O'Sullivan TJ, DiRico KJ, McDonald WS, Won A, Dorff PH, Nolan CE, Becker SL, Pustilnik LR, Riddell DR, Kauffman GW, Kormos BL, Zhang L, Lu Y, Capetta SH, Green ME, Karki K, Sibley E, Atchison KP, Hallgren AJ, Oborski CE, Robshaw AE, Sneed B, O'Donnell CJ. Stepan AF, et al. J Med Chem. 2012 Apr 12;55(7):3414-24. doi: 10.1021/jm300094u. Epub 2012 Mar 29. J Med Chem. 2012. PMID: 22420884
Synthetic approaches to the 2011 new drugs.
Ding HX, Liu KK, Sakya SM, Flick AC, O'Donnell CJ. Ding HX, et al. Bioorg Med Chem. 2013 Jun 1;21(11):2795-825. doi: 10.1016/j.bmc.2013.02.061. Epub 2013 Apr 6. Bioorg Med Chem. 2013. PMID: 23623674 Review.
744 results