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A patent review of MALT1 inhibitors (2013-present).
Hamp I, O'Neill TJ, Plettenburg O, Krappmann D. Hamp I, et al. Among authors: o neill tj. Expert Opin Ther Pat. 2021 Dec;31(12):1079-1096. doi: 10.1080/13543776.2021.1951703. Epub 2021 Jul 15. Expert Opin Ther Pat. 2021. PMID: 34214002 Review.
TRAF6 prevents fatal inflammation by homeostatic suppression of MALT1 protease.
O'Neill TJ, Seeholzer T, Gewies A, Gehring T, Giesert F, Hamp I, Graß C, Schmidt H, Kriegsmann K, Tofaute MJ, Demski K, Poth T, Rosenbaum M, Schnalzger T, Ruland J, Göttlicher M, Kriegsmann M, Naumann R, Heissmeyer V, Plettenburg O, Wurst W, Krappmann D. O'Neill TJ, et al. Sci Immunol. 2021 Nov 12;6(65):eabh2095. doi: 10.1126/sciimmunol.abh2095. Epub 2021 Nov 12. Sci Immunol. 2021. PMID: 34767456
Function and targeting of MALT1 paracaspase in cancer.
O'Neill TJ, Tofaute MJ, Krappmann D. O'Neill TJ, et al. Cancer Treat Rev. 2023 Jun;117:102568. doi: 10.1016/j.ctrv.2023.102568. Epub 2023 Apr 26. Cancer Treat Rev. 2023. PMID: 37126937 Free article. Review.
Unrestrained cleavage of Roquin-1 by MALT1 induces spontaneous T cell activation and the development of autoimmunity.
Schmidt H, Raj T, O'Neill TJ, Muschaweckh A, Giesert F, Negraschus A, Hoefig KP, Behrens G, Esser L, Baumann C, Feederle R, Plaza-Sirvent C, Geerlof A, Gewies A, Isay SE, Ruland J, Schmitz I, Wurst W, Korn T, Krappmann D, Heissmeyer V. Schmidt H, et al. Among authors: o neill tj. Proc Natl Acad Sci U S A. 2023 Nov 28;120(48):e2309205120. doi: 10.1073/pnas.2309205120. Epub 2023 Nov 21. Proc Natl Acad Sci U S A. 2023. PMID: 37988467 Free PMC article.
TPC1 deficiency or blockade augments systemic anaphylaxis and mast cell activity.
Arlt E, Fraticelli M, Tsvilovskyy V, Nadolni W, Breit A, O'Neill TJ, Resenberger S, Wennemuth G, Wahl-Schott C, Biel M, Grimm C, Freichel M, Gudermann T, Klugbauer N, Boekhoff I, Zierler S. Arlt E, et al. Proc Natl Acad Sci U S A. 2020 Jul 28;117(30):18068-18078. doi: 10.1073/pnas.1920122117. Epub 2020 Jul 13. Proc Natl Acad Sci U S A. 2020. PMID: 32661165 Free PMC article.
169 results