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29 results

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Page 1
Abnormal accumulation of OFD1 in endometrial cancer with poor prognosis inhibits ciliogenesis.
Kojima R, Hassan E, Ozawa F, Yamada-Namikawa C, Ogawa S, Mase S, Goto S, Nishikawa R, Inagaki H, Kato Y, Sugiura-Ogasawara M. Kojima R, et al. Oncol Lett. 2022 May 17;24(1):214. doi: 10.3892/ol.2022.13334. eCollection 2022 Jul. Oncol Lett. 2022. PMID: 35720483 Free PMC article.
To examine the association between autophagy and ciliogenesis in endometrioid carcinoma, the expression of p62/Sequestosome-1, a selective substrate for autophagy, and oral-facial-digital syndrome 1 protein (OFD1), a protein associated with ciliogenesis, were examined usin …
To examine the association between autophagy and ciliogenesis in endometrioid carcinoma, the expression of p62/Sequestosome-1, a selective s …
The Relationship Between Human Papillomavirus, OFD1 and Primary Ciliogenesis in the Progression of Oropharyngeal Cancer: A Retrospective Cohort Study.
Meng HX, Yang XX, Liu RQ, Bao JJ, Hou YJ, Sun J, Miao SS, Qu GF. Meng HX, et al. Pharmgenomics Pers Med. 2020 Nov 17;13:633-644. doi: 10.2147/PGPM.S271735. eCollection 2020. Pharmgenomics Pers Med. 2020. PMID: 33244255 Free PMC article.
Primary ciliogenesis defects contribute to tumorigenesis, and OFD1 at centriolar satellites is a crucial suppressor of primary ciliogenesis. ...Expression of TSLP on dendritic cells in HPV-positive OPSCC correlated with the expression of OFD1. HPV-positive OPSCC sho …
Primary ciliogenesis defects contribute to tumorigenesis, and OFD1 at centriolar satellites is a crucial suppressor of primary ciliog …
An actin filament branching surveillance system regulates cell cycle progression, cytokinesis and primary ciliogenesis.
Cao M, Zou X, Li C, Lin Z, Wang N, Zou Z, Ye Y, Seemann J, Levine B, Tang Z, Zhong Q. Cao M, et al. Nat Commun. 2023 Mar 27;14(1):1687. doi: 10.1038/s41467-023-37340-z. Nat Commun. 2023. PMID: 36973243 Free PMC article.
Inhibition of OFD1 leads to suppression of multiple cancer cell growth in mouse xenograft models. Thus, targeting OFD1-mediated actin filament branching surveillance system provides a direction for cancer therapy....
Inhibition of OFD1 leads to suppression of multiple cancer cell growth in mouse xenograft models. Thus, targeting OFD1- …
Ciliary Genes in Renal Cystic Diseases.
Adamiok-Ostrowska A, Piekiełko-Witkowska A. Adamiok-Ostrowska A, et al. Cells. 2020 Apr 8;9(4):907. doi: 10.3390/cells9040907. Cells. 2020. PMID: 32276433 Free PMC article. Review.
The impaired functioning of primary cilia leads to formation of cysts which in turn contribute to development of diverse renal diseases, including kidney ciliopathies and renal cancer. Here, we review current knowledge on the role of ciliary genes in kidney ciliopathies an …
The impaired functioning of primary cilia leads to formation of cysts which in turn contribute to development of diverse renal diseases, inc …
The TBC1D31/praja2 complex controls primary ciliogenesis through PKA-directed OFD1 ubiquitylation.
Senatore E, Chiuso F, Rinaldi L, Intartaglia D, Delle Donne R, Pedone E, Catalanotti B, Pirone L, Fiorillo B, Moraca F, Giamundo G, Scala G, Raffeiner A, Torres-Quesada O, Stefan E, Kwiatkowski M, van Pijkeren A, Morleo M, Franco B, Garbi C, Conte I, Feliciello A. Senatore E, et al. EMBO J. 2021 May 17;40(10):e106503. doi: 10.15252/embj.2020106503. Epub 2021 May 2. EMBO J. 2021. PMID: 33934390 Free PMC article.
OFD1 plays a key role in cilium biogenesis. However, the impact of signalling pathways and the role of the ubiquitin-proteasome system (UPS) in the control of OFD1 stability remain unknown. Here, we identify a novel complex assembled at centrosomes by TBC1D31, inclu …
OFD1 plays a key role in cilium biogenesis. However, the impact of signalling pathways and the role of the ubiquitin-proteasome syste …
A new deep learning technique reveals the exclusive functional contributions of individual cancer mutations.
Gupta P, Jindal A, Ahuja G, Jayadeva, Sengupta D. Gupta P, et al. J Biol Chem. 2022 Aug;298(8):102177. doi: 10.1016/j.jbc.2022.102177. Epub 2022 Jun 24. J Biol Chem. 2022. PMID: 35753349 Free PMC article.
Cancers are caused by genomic alterations that may be inherited, induced by environmental carcinogens, or caused due to random replication errors. ...Second, the proposed approach also enables identification and exploration of driver genes; our analyses implicate DMD, RSK4 …
Cancers are caused by genomic alterations that may be inherited, induced by environmental carcinogens, or caused due to random replic …
Autophagy promotes primary ciliogenesis by removing OFD1 from centriolar satellites.
Tang Z, Lin MG, Stowe TR, Chen S, Zhu M, Stearns T, Franco B, Zhong Q. Tang Z, et al. Nature. 2013 Oct 10;502(7470):254-7. doi: 10.1038/nature12606. Epub 2013 Oct 2. Nature. 2013. PMID: 24089205 Free PMC article.
These defects are fully rescued by OFD1 partial knockdown that reduces the population of OFD1 at centriolar satellites. More strikingly, OFD1 depletion at centriolar satellites promotes cilia formation in both cycling cells and transformed breast cancer …
These defects are fully rescued by OFD1 partial knockdown that reduces the population of OFD1 at centriolar satellites. More s …
OFD1 and flotillins are integral components of a ciliary signaling protein complex organized by polycystins in renal epithelia and odontoblasts.
Jerman S, Ward HH, Lee R, Lopes CA, Fry AM, MacDougall M, Wandinger-Ness A. Jerman S, et al. PLoS One. 2014 Sep 2;9(9):e106330. doi: 10.1371/journal.pone.0106330. eCollection 2014. PLoS One. 2014. PMID: 25180832 Free PMC article.
Mutation of the X-linked oral-facial-digital syndrome type 1 (OFD1) gene is embryonic lethal in males and results in craniofacial malformations and adult onset polycystic kidney disease in females. While the OFD1 protein localizes to centriolar satellites, centrosom …
Mutation of the X-linked oral-facial-digital syndrome type 1 (OFD1) gene is embryonic lethal in males and results in craniofacial mal …
Oral-facial-digital syndrome type I cells exhibit impaired DNA repair; unanticipated consequences of defective OFD1 outside of the cilia network.
Abramowicz I, Carpenter G, Alfieri M, Colnaghi R, Outwin E, Parent P, Thauvin-Robinet C, Iaconis D, Franco B, O'Driscoll M. Abramowicz I, et al. Hum Mol Genet. 2017 Jan 1;26(1):19-32. doi: 10.1093/hmg/ddw364. Hum Mol Genet. 2017. PMID: 27798113
Defects in OFD1 underlie the clinically complex ciliopathy, Oral-Facial-Digital syndrome Type I (OFD Type I). ...These data extend our knowledge of the molecular and cellular consequences of impaired OFD1, demonstrating that loss of OFD1 can negatively impact …
Defects in OFD1 underlie the clinically complex ciliopathy, Oral-Facial-Digital syndrome Type I (OFD Type I). ...These data extend ou …
Self-eating to remove cilia roadblock.
Tang Z, Zhu M, Zhong Q. Tang Z, et al. Autophagy. 2014 Feb;10(2):379-81. doi: 10.4161/auto.27346. Epub 2013 Dec 12. Autophagy. 2014. PMID: 24343661 Free PMC article.
OFD1 regulation and primary cilium formation are defective in autophagy-deficient cells, and reducing OFD1 protein levels through RNA interference rescues primary cilium formation. More strikingly, knockdown of OFD1 induces primary cilium formation in unstres …
OFD1 regulation and primary cilium formation are defective in autophagy-deficient cells, and reducing OFD1 protein levels thro …
29 results