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The expression of kappa-opioid receptor promotes the migration of breast cancer cells in vitro.
Li H, Ma Z, Lei Y. Li H, et al. BMC Anesthesiol. 2021 Aug 30;21(1):210. doi: 10.1186/s12871-021-01429-z. BMC Anesthesiol. 2021. PMID: 34461834 Free PMC article.
BACKGROUND: Opioid receptors are implicated in cell proliferation and cancer migration. However, the effects and underlying mechanisms of opioid receptor kappa (OPRK1) in breast cancer remain unknown. ...OPRK1 knockdown could inhibited cell viability a …
BACKGROUND: Opioid receptors are implicated in cell proliferation and cancer migration. However, the effects and underlying mechanism …
Pan-Cancer Analysis and Validation of Opioid-Related Receptors Reveals the Immunotherapeutic Value of Toll-Like Receptor 4.
Wu S, Chen J, Huang E, Zhang Y. Wu S, et al. Int J Gen Med. 2023 Nov 24;16:5527-5548. doi: 10.2147/IJGM.S434076. eCollection 2023. Int J Gen Med. 2023. PMID: 38034898 Free PMC article.
INTRODUCTION: The relationship between the expression of opioid-associated receptors and cancer outcomes is complex and varies among studies. METHODS: This study focused on six opioid-related receptors (OPRM1, OPRD1, OPRK1, OPRL1, OGFR, and TLR4) and their impact on …
INTRODUCTION: The relationship between the expression of opioid-associated receptors and cancer outcomes is complex and varies among …
The role of miRNA-144-3p/Oprk1/KOR in nicotine dependence and nicotine withdrawal in male rats.
Shao J, Fei Y, Xiao J, Wang L, Zou S, Yang J. Shao J, et al. Nicotine Tob Res. 2023 Nov 22;25(12):1856-1864. doi: 10.1093/ntr/ntad118. Nicotine Tob Res. 2023. PMID: 37455648 Free PMC article.
Biochemical analyses demonstrated that miR-144-3p expression decreased and Oprk1/KOR expression increased in the prefrontal cortex, nucleus accumben, and hippocampus. Further investigation suggested that miR-144-3p exerted an inhibitory effect on Oprk1 expression in …
Biochemical analyses demonstrated that miR-144-3p expression decreased and Oprk1/KOR expression increased in the prefrontal cortex, n …
Comprehensive genomics in androgen receptor-dependent castration-resistant prostate cancer identifies an adaptation pathway mediated by opioid receptor kappa 1.
Makino Y, Kamiyama Y, Brown JB, Tanaka T, Murakami R, Teramoto Y, Goto T, Akamatsu S, Terada N, Inoue T, Kodama T, Ogawa O, Kobayashi T. Makino Y, et al. Commun Biol. 2022 Apr 1;5(1):299. doi: 10.1038/s42003-022-03227-w. Commun Biol. 2022. PMID: 35365763 Free PMC article.
Castration resistance is a lethal form of treatment failure of prostate cancer (PCa) and is associated with ligand-independent activation of the androgen receptor (AR). ...Immunohistochemical analysis showed that expression of OPRK1, a G protein-coupled receptor, wa …
Castration resistance is a lethal form of treatment failure of prostate cancer (PCa) and is associated with ligand-independent activa …
miRNAs in the Expression Regulation of Dopamine-Related Genes and Proteins in Endometrial Cancer.
Czerwiński M, Bednarska-Czerwińska A, Zmarzły N, Boroń D, Oplawski M, Grabarek BO. Czerwiński M, et al. J Clin Med. 2021 Oct 26;10(21):4939. doi: 10.3390/jcm10214939. J Clin Med. 2021. PMID: 34768458 Free PMC article.
Sixty women were recruited for the study: 30 with endometrial cancer and 30 without cancer. The expression profiles of dopamine-related genes were determined in endometrial tissue samples using microarrays and qRT-PCR. ...Low COMT expression was probably not associa …
Sixty women were recruited for the study: 30 with endometrial cancer and 30 without cancer. The expression profiles of dopamin …
Intraoperative opioids are associated with improved recurrence-free survival in triple-negative breast cancer.
Montagna G, Gupta HV, Hannum M, Tan KS, Lee J, Scarpa JR, Plitas G, Irie T, McCormick PJ, Fischer GW, Morrow M, Mincer JS. Montagna G, et al. Br J Anaesth. 2021 Feb;126(2):367-376. doi: 10.1016/j.bja.2020.10.021. Epub 2020 Nov 19. Br J Anaesth. 2021. PMID: 33220939 Free PMC article.
At a single-cell level, OPRM1 and OPRD1 were not detectable; OPRK1 was expressed mainly on tumour cells, whereas OGFR and TLR4 were more highly expressed on immune cells. ...In this era of personalised medicine, efforts to differentiate the effects of opioids across breast …
At a single-cell level, OPRM1 and OPRD1 were not detectable; OPRK1 was expressed mainly on tumour cells, whereas OGFR and TLR4 were m …
Opioid treatment failure in cancer patients: the role of clinical and genetic factors.
Oosten AW, Matic M, van Schaik RH, Look MP, Jongen JL, Mathijssen RH, van der Rijt CC. Oosten AW, et al. Pharmacogenomics. 2016 Aug;17(13):1391-403. doi: 10.2217/pgs-2016-0082. Epub 2016 Jul 29. Pharmacogenomics. 2016. PMID: 27472837
PATIENTS & METHODS: We performed an exploratory analysis in a cohort of 353 patients treated with fentanyl, morphine, oxycodone and/or hydromorphone for cancer-related pain, exploring selected clinical and pharmacogenetic factors for a correlation with treatment failur …
PATIENTS & METHODS: We performed an exploratory analysis in a cohort of 353 patients treated with fentanyl, morphine, oxycodone and/or h …
LNCaP Atlas: gene expression associated with in vivo progression to castration-recurrent prostate cancer.
Romanuik TL, Wang G, Morozova O, Delaney A, Marra MA, Sadar MD. Romanuik TL, et al. BMC Med Genomics. 2010 Sep 24;3:43. doi: 10.1186/1755-8794-3-43. BMC Med Genomics. 2010. PMID: 20868494 Free PMC article.
BACKGROUND: There is no cure for castration-recurrent prostate cancer (CRPC) and the mechanisms underlying this stage of the disease are unknown. METHODS: We analyzed the transcriptome of human LNCaP prostate cancer cells as they progress to CRPC in vivo using repli …
BACKGROUND: There is no cure for castration-recurrent prostate cancer (CRPC) and the mechanisms underlying this stage of the disease …
Exploration of the Tumor Mutational Burden as a Prognostic Biomarker and Related Hub Gene Identification in Prostate Cancer.
Wang L, Yao Y, Xu C, Wang X, Wu D, Hong Z. Wang L, et al. Technol Cancer Res Treat. 2021 Jan-Dec;20:15330338211052154. doi: 10.1177/15330338211052154. Technol Cancer Res Treat. 2021. PMID: 34806485 Free PMC article.
To explore the signature function of the tumor mutational burden (TMB) and potential biomarkers in prostate cancer (PCa), transcriptome profiles, somatic mutation data, and clinicopathologic feature information were downloaded from The Cancer Genome Atlas (TCGA) dat …
To explore the signature function of the tumor mutational burden (TMB) and potential biomarkers in prostate cancer (PCa), transcripto …
Androgen represses opioid growth factor receptor (OGFR) in human prostate cancer LNCaP cells and OGFR expression in human prostate cancer tissue.
Yamashita H, Shuman L, Warrick JI, Raman JD, Degraff DJ. Yamashita H, et al. Am J Clin Exp Urol. 2018 Aug 20;6(4):164-171. eCollection 2018. Am J Clin Exp Urol. 2018. PMID: 30246052 Free PMC article.
In the present study, we examined opioid receptor expression in human prostate cancer cell lines and in prostate cancer tissue. We observed using quantitative real-time PCR analysis that OGFR and OGFRL1 mRNA is expressed in all examined prostate cancer cell l …
In the present study, we examined opioid receptor expression in human prostate cancer cell lines and in prostate cancer tissue …
27 results