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Integrated analysis of histone lysine lactylation (Kla)-specific genes suggests that NR6A1, OSBP2 and UNC119B are novel therapeutic targets for hepatocellular carcinoma.
Wu Q, Li X, Long M, Xie X, Liu Q. Wu Q, et al. Sci Rep. 2023 Oct 30;13(1):18642. doi: 10.1038/s41598-023-46057-4. Sci Rep. 2023. PMID: 37903971 Free PMC article.
OSBP2 and UNC119B were identified to be related to chemotherapy resistance. ...In summary, histone Kla was related to HCC prognosis and might serve as an independent biomarker. NR6A1, OSBP2 and UNC119B were associated with the prognosis, immunotherapy, and chemother …
OSBP2 and UNC119B were identified to be related to chemotherapy resistance. ...In summary, histone Kla was related to HCC prognosis a …
Oxysterol-Binding Protein 2 Promotes Pancreatic Ductal Adenocarcinoma Progression Through Epithelial-Mesenchymal Transition.
Huang S, Zhang X, Luo K, Jiang L, Jiang J, Li R. Huang S, et al. Front Oncol. 2022 Jan 20;11:762233. doi: 10.3389/fonc.2021.762233. eCollection 2021. Front Oncol. 2022. PMID: 35127474 Free PMC article.
Oxysterol-binding protein 2 (OSBP2) is crucial for promoting the growth and development of cancers; however, its effects on pancreatic ductal adenocarcinoma (PDAC) are still unclear. ...Taken together, our findings indicated that OSBP2 was overexpressed in PD …
Oxysterol-binding protein 2 (OSBP2) is crucial for promoting the growth and development of cancers; however, its effects on pa …
HLM/OSBP2 is expressed in chronic myeloid leukemia.
Henriques Silva N, Vasconcellos Fournier M, Pimenta G, Pulcheri WA, Spector N, da Costa Carvalho Mda G. Henriques Silva N, et al. Int J Mol Med. 2003 Oct;12(4):663-6. Int J Mol Med. 2003. PMID: 12964051
In this study we focused on the evaluation of HLM/OSBP2 expression in malignant cell lines from different origins (blood and solid tumors) and we also evaluated its expression in chronic myeloid leukemia patients, correlating the molecular findings with clinical outcome. O …
In this study we focused on the evaluation of HLM/OSBP2 expression in malignant cell lines from different origins (blood and solid tu …
Expression of oxysterol binding protein isoforms in opisthorchiasis-associated cholangiocarcinoma: a potential molecular marker for tumor metastasis.
Loilome W, Wechagama P, Namwat N, Jusakul A, Sripa B, Miwa M, Kuver R, Yongvanit P. Loilome W, et al. Parasitol Int. 2012 Mar;61(1):136-9. doi: 10.1016/j.parint.2011.07.003. Epub 2011 Jul 8. Parasitol Int. 2012. PMID: 21763455
Interestingly, in our preliminary results, significantly higher levels of OSBP2 and OSBPL-7 mRNA were seen in blood samples from CCA patients than in healthy controls. These results suggest that OSBP2 and OSBPL-7 might serve as molecular markers for the identificati …
Interestingly, in our preliminary results, significantly higher levels of OSBP2 and OSBPL-7 mRNA were seen in blood samples from CCA …
Essential role of PTPN11 mutation in enhanced haematopoietic differentiation potential of induced pluripotent stem cells of juvenile myelomonocytic leukaemia.
Shigemura T, Matsuda K, Kurata T, Sakashita K, Okuno Y, Muramatsu H, Yue F, Ebihara Y, Tsuji K, Sasaki K, Nakahata T, Nakazawa Y, Koike K. Shigemura T, et al. Br J Haematol. 2019 Oct;187(2):163-173. doi: 10.1111/bjh.16060. Epub 2019 Jun 20. Br J Haematol. 2019. PMID: 31222725 Free article.
The haematopoietic differentiation potential of non-mutated JMML iPSC colonies was similar to or lower than that of iPSC colonies from a healthy individual. The PTPN11 mutation coexisted with the OSBP2 c.389C>T mutation. Zinc-finger nuclease-mediated homologous recombin …
The haematopoietic differentiation potential of non-mutated JMML iPSC colonies was similar to or lower than that of iPSC colonies from a hea …
A novel variant in SMG9 causes intellectual disability, confirming a role for nonsense-mediated decay components in neurocognitive development.
Rahikkala E, Urpa L, Ghimire B, Topa H, Kurki MI, Koskela M, Airavaara M, Hämäläinen E, Pylkäs K, Körkkö J, Savolainen H, Suoranta A, Bertoli-Avella A, Rolfs A, Mattila P, Daly M, Palotie A, Pietiläinen O, Moilanen J, Kuismin O. Rahikkala E, et al. Eur J Hum Genet. 2022 May;30(5):619-627. doi: 10.1038/s41431-022-01046-5. Epub 2022 Jan 28. Eur J Hum Genet. 2022. PMID: 35087184 Free PMC article.
Differential gene expression analysis identified prevalent upregulation of genes in patients, including the genes SMOX, OSBP2, GPX3, and ZNF155. These findings suggest that normal SMG9 function may be involved in transcriptional regulation without affecting nonsense mRNA-i …
Differential gene expression analysis identified prevalent upregulation of genes in patients, including the genes SMOX, OSBP2, GPX3, …
Identification and validation of candidate clinical signatures of apolipoprotein L isoforms in hepatocellular carcinoma.
Wang XK, Guo YX, Wang M, Zhang XD, Liu ZY, Wang MS, Luo K, Huang S, Li RF. Wang XK, et al. Sci Rep. 2023 Nov 28;13(1):20969. doi: 10.1038/s41598-023-48366-0. Sci Rep. 2023. PMID: 38017264 Free PMC article.
Apolipoprotein (APOL) isoforms have been explored for their associations with HCC.The GSE14520 cohort was used for training data; The Cancer Genome Atlas (TCGA) database was used for validated data. Diagnostic, prognostic significance and mechanisms were explored using the …
Apolipoprotein (APOL) isoforms have been explored for their associations with HCC.The GSE14520 cohort was used for training data; The Can …