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Osr2 functions as a biomechanical checkpoint to aggravate CD8(+) T cell exhaustion in tumor.
Zhang J, Li J, Hou Y, Lin Y, Zhao H, Shi Y, Chen K, Nian C, Tang J, Pan L, Xing Y, Gao H, Yang B, Song Z, Cheng Y, Liu Y, Sun M, Linghu Y, Li J, Huang H, Lai Z, Zhou Z, Li Z, Sun X, Chen Q, Su D, Li W, Peng Z, Liu P, Chen W, Huang H, Chen Y, Xiao B, Ye L, Chen L, Zhou D. Zhang J, et al. Cell. 2024 May 9:S0092-8674(24)00448-3. doi: 10.1016/j.cell.2024.04.023. Online ahead of print. Cell. 2024. PMID: 38744281
Consistently, depletion of Osr2 alleviates the exhaustion of tumor-specific CD8(+) T cells or CAR-T cells, whereas forced Osr2 expression aggravates their exhaustion in solid tumor models. ...Thus, our results unravel Osr2 functions as a biomechanical checkpo …
Consistently, depletion of Osr2 alleviates the exhaustion of tumor-specific CD8(+) T cells or CAR-T cells, whereas forced Osr2 …
Detection of OSR2, VAV3, and PPFIA3 Methylation in the Serum of Patients with Gastric Cancer.
Li WH, Zhou ZJ, Huang TH, Guo K, Chen W, Wang Y, Zhang H, Song YC, Chang DM. Li WH, et al. Dis Markers. 2016;2016:5780538. doi: 10.1155/2016/5780538. Epub 2016 Apr 7. Dis Markers. 2016. PMID: 27143812 Free PMC article.
AIM: This study was to evaluate the diagnostic value of OSR2, VAV3, and PPFIA3 hypermethylation in gastric cancer (GC) patients. PATIENTS AND METHODS: By using methylation-specific polymerase chain reaction (MSP), we detected the methylation status in tissue and ser …
AIM: This study was to evaluate the diagnostic value of OSR2, VAV3, and PPFIA3 hypermethylation in gastric cancer (GC) patient …
A comprehensive molecular characterization of the 8q22.2 region reveals the prognostic relevance of OSR2 mRNA in muscle invasive bladder cancer.
Uysal D, Kowalewski KF, Kriegmair MC, Wirtz R, Popovic ZV, Erben P. Uysal D, et al. PLoS One. 2021 Mar 12;16(3):e0248342. doi: 10.1371/journal.pone.0248342. eCollection 2021. PLoS One. 2021. PMID: 33711044 Free PMC article.
To investigate the prognostic role of 8q22.2 and to compare different amplicon definitions, an in-silico analysis of 357 patients from The Cancer Genome Atlas, who underwent radical cystectomy for MIBC, was performed. ...In this study, OSR2 is identified as a potent …
To investigate the prognostic role of 8q22.2 and to compare different amplicon definitions, an in-silico analysis of 357 patients from The …
A bespoke target selection tool to guide biomarker discovery in tubo-ovarian cancer.
Beirne JP, Gilmore A, McInerney CE, Roddy A, Glenn McCluggage W, Harley IJG, Abdullah Alvi M, Prise KM, McArt DG, Mullan PB. Beirne JP, et al. Comput Struct Biotechnol J. 2022 Jun 17;20:3359-3371. doi: 10.1016/j.csbj.2022.06.016. eCollection 2022. Comput Struct Biotechnol J. 2022. PMID: 35832628 Free PMC article.
INTRODUCTION: Cancers presenting at advanced stages inherently have poor prognosis. ...The OSR2 methylation biomarker could discriminate HGSC with high specificity (95%) and sensitivity (93.18%). ...
INTRODUCTION: Cancers presenting at advanced stages inherently have poor prognosis. ...The OSR2 methylation biomarker could di …
Identification of core genes in the progression of endometrial cancer and cancer cell-derived exosomes by an integrative analysis.
Shi S, Tan Q, Feng F, Huang H, Liang J, Cao D, Wang Z. Shi S, et al. Sci Rep. 2020 Jun 17;10(1):9862. doi: 10.1038/s41598-020-66872-3. Sci Rep. 2020. PMID: 32555395 Free PMC article.
In addition, exosomes derived from endometrial cancer cells were also isolated and identified. First, we analyzed the differentially expressed genes (DEGs) between endometrial cancer tissues and normal tissues in clinic samples. We found that HAND2-AS1, PEG3, OGN, S …
In addition, exosomes derived from endometrial cancer cells were also isolated and identified. First, we analyzed the differentially …
Establishment of a DNA methylation marker to evaluate cancer cell fraction in gastric cancer.
Zong L, Hattori N, Yoda Y, Yamashita S, Takeshima H, Takahashi T, Maeda M, Katai H, Nanjo S, Ando T, Seto Y, Ushijima T. Zong L, et al. Gastric Cancer. 2016 Apr;19(2):361-369. doi: 10.1007/s10120-015-0475-2. Epub 2015 Feb 13. Gastric Cancer. 2016. PMID: 25678126
RESULTS: Genome-wide DNA methylation analysis of 12 GC cell lines, 30 GCs, six normal gastric mucosae, one sample of peripheral leukocytes, and four noncancerous gastric mucosae identified OSR2, PPFIA3, and VAV3 as barely methylated in normal cells and highly methylated in …
RESULTS: Genome-wide DNA methylation analysis of 12 GC cell lines, 30 GCs, six normal gastric mucosae, one sample of peripheral leukocytes, …
Integrative genomics analysis reveals the multilevel dysregulation and oncogenic characteristics of TEAD4 in gastric cancer.
Lim B, Park JL, Kim HJ, Park YK, Kim JH, Sohn HA, Noh SM, Song KS, Kim WH, Kim YS, Kim SY. Lim B, et al. Carcinogenesis. 2014 May;35(5):1020-7. doi: 10.1093/carcin/bgt409. Epub 2013 Dec 9. Carcinogenesis. 2014. PMID: 24325916
To uncover previously unrecognized genes that undergo multilevel perturbations in gastric cancer (GC), we integrated epigenomic and transcriptomic approaches using two recently developed tools: MENT and GENT. ...Finally, chromatin immunoprecipitation-sequencing and microar …
To uncover previously unrecognized genes that undergo multilevel perturbations in gastric cancer (GC), we integrated epigenomic and t …
Molecular cloning and characterization of OSR1 on human chromosome 2p24.
Katoh M. Katoh M. Int J Mol Med. 2002 Aug;10(2):221-5. Int J Mol Med. 2002. PMID: 12119563
Three zinc fingers and a tyrosine phosphorylation site were conserved among human OSR1, OSR2, Drosophila odd, sob, and bowl. OSR1 showed 63.6% total amino-acid identity with OSR2. ...OSR1 mRNA of 2.3-kb in size was detected in adult colon, small intestine, prostate, …
Three zinc fingers and a tyrosine phosphorylation site were conserved among human OSR1, OSR2, Drosophila odd, sob, and bowl. OSR1 sho …
MicroRNA-361-3p is a potent therapeutic target for oral squamous cell carcinoma.
Ogawa H, Nakashiro KI, Tokuzen N, Kuribayashi N, Goda H, Uchida D. Ogawa H, et al. Cancer Sci. 2020 May;111(5):1645-1651. doi: 10.1111/cas.14359. Epub 2020 Mar 18. Cancer Sci. 2020. PMID: 32086979 Free PMC article.
Transfection with a synthetic mimic of mature miR-361-3p resulted in an approximately 20% increase in the growth of GFP-SAS cells. We identified odd-skipped related 2 (OSR2) as a miR-361-3p target gene. Transfection of GFP-SAS cells with LNA-miR-361-3p caused a significant …
Transfection with a synthetic mimic of mature miR-361-3p resulted in an approximately 20% increase in the growth of GFP-SAS cells. We identi …
Differentially methylated genes in proliferative verrucous leukoplakia reveal potential malignant biomarkers for oral squamous cell carcinoma.
Herreros-Pomares A, Llorens C, Soriano B, Bagan L, Moreno A, Calabuig-Fariñas S, Jantus-Lewintre E, Bagan J. Herreros-Pomares A, et al. Oral Oncol. 2021 May;116:105191. doi: 10.1016/j.oraloncology.2021.105191. Epub 2021 Feb 28. Oral Oncol. 2021. PMID: 33657465
Network analysis revealed three major hubs, two of them collecting proteins related to the response of the patients to PVL and treatment and one hub collecting proteins related to PVL and cancer. The integrative analysis revealed 8 genes (ARTN, CD8A, GATA3, HOXD10, MYO7A, …
Network analysis revealed three major hubs, two of them collecting proteins related to the response of the patients to PVL and treatment and …
14 results