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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1877 1
1899 2
1904 1
1945 1
1947 1
1948 2
1949 1
1950 1
1951 4
1952 1
1953 2
1954 1
1956 2
1957 1
1958 2
1959 3
1960 2
1961 2
1962 4
1963 10
1964 32
1965 10
1966 2
1967 6
1968 7
1969 4
1970 6
1971 4
1972 4
1973 3
1974 3
1975 10
1976 12
1977 13
1978 17
1979 15
1980 13
1981 22
1982 18
1983 27
1984 22
1985 37
1986 22
1987 31
1988 38
1989 35
1990 55
1991 53
1992 55
1993 70
1994 57
1995 67
1996 90
1997 87
1998 120
1999 108
2000 166
2001 189
2002 198
2003 249
2004 258
2005 319
2006 357
2007 338
2008 387
2009 415
2010 400
2011 422
2012 441
2013 527
2014 479
2015 547
2016 564
2017 573
2018 621
2019 649
2020 677
2021 765
2022 789
2023 690
2024 361

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The following term was not found in PubMed: Oen-Hiang
Page 1
Therapeutic targeting of the angiopoietin-TIE pathway.
Saharinen P, Eklund L, Alitalo K. Saharinen P, et al. Nat Rev Drug Discov. 2017 Sep;16(9):635-661. doi: 10.1038/nrd.2016.278. Epub 2017 May 19. Nat Rev Drug Discov. 2017. PMID: 28529319 Review.
Drugs that target the ANG-TIE pathway are in clinical development for oncological and ophthalmological applications. ...This Review covers key aspects of the function of the ANG-TIE pathway in vascular disease and describes the recent development of novel therapeuti …
Drugs that target the ANG-TIE pathway are in clinical development for oncological and ophthalmological applications. ...This Review c …
Effectiveness of tongue-tie assessment tools in diagnosing and fulfilling lingual frenectomy criteria: a systematic review.
Hatami A, Dreyer CW, Meade MJ, Kaur S. Hatami A, et al. Aust Dent J. 2022 Sep;67(3):212-219. doi: 10.1111/adj.12921. Epub 2022 Jul 4. Aust Dent J. 2022. PMID: 35689515 Free PMC article. Review.
It is unclear how effective tongue-tie classification assessment tools are in diagnosing symptomatic tongue-tie and fulfilling lingual frenectomy criteria. The purpose of this systematic review is to determine and evaluate any association between tongue-tie s …
It is unclear how effective tongue-tie classification assessment tools are in diagnosing symptomatic tongue-tie and fulfilling …
Lymphangiogenesis requires Ang2/Tie/PI3K signaling for VEGFR3 cell-surface expression.
Korhonen EA, Murtomäki A, Jha SK, Anisimov A, Pink A, Zhang Y, Stritt S, Liaqat I, Stanczuk L, Alderfer L, Sun Z, Kapiainen E, Singh A, Sultan I, Lantta A, Leppänen VM, Eklund L, He Y, Augustin HG, Vaahtomeri K, Saharinen P, Mäkinen T, Alitalo K. Korhonen EA, et al. J Clin Invest. 2022 Aug 1;132(15):e155478. doi: 10.1172/JCI155478. J Clin Invest. 2022. PMID: 35763346 Free PMC article.
A similar effect was observed in LECs upon deletion of the PI3K catalytic p110alpha subunit or with small-molecule inhibition of a constitutively active PI3K located downstream of Ang2. Deletion of Tie receptors or blockade of Ang2 decreased VEGF-C-induced lymphangiogenesi …
A similar effect was observed in LECs upon deletion of the PI3K catalytic p110alpha subunit or with small-molecule inhibition of a constitut …
Angiopoietins in angiogenesis.
Fagiani E, Christofori G. Fagiani E, et al. Cancer Lett. 2013 Jan 1;328(1):18-26. doi: 10.1016/j.canlet.2012.08.018. Epub 2012 Aug 23. Cancer Lett. 2013. PMID: 22922303 Review.
Tie-1 and Tie-2 are essential for vascular maturation during developmental, physiological and pathological angiogenesis. Angiopoietin 1-4 (Ang-1-4) have been identified as bona fide ligands of the Tie-2 receptor, while Tie-1 remains an orphan receptor …
Tie-1 and Tie-2 are essential for vascular maturation during developmental, physiological and pathological angiogenesis. Angio …
Ankyloglossia and Other Oral Ties.
Walsh J, McKenna Benoit M. Walsh J, et al. Otolaryngol Clin North Am. 2019 Oct;52(5):795-811. doi: 10.1016/j.otc.2019.06.008. Epub 2019 Jul 25. Otolaryngol Clin North Am. 2019. PMID: 31353141 Review.
This article presents the latest evidence on the diagnosis and management of tongue-tie and outlines some of the controversies and gaps in the existing evidence. Anterior tongue-tie is accepted in most clinical practices as a potential risk for breastfeeding difficu …
This article presents the latest evidence on the diagnosis and management of tongue-tie and outlines some of the controversies and ga …
The effect of frenectomy for tongue-tie, lip-tie, or cheek-tie on breastfeeding outcomes: A systematic review of articles over time and suggestions for management.
Carnino JM, Walia AS, Lara FR, Mwaura AM, Levi JR. Carnino JM, et al. Int J Pediatr Otorhinolaryngol. 2023 Aug;171:111638. doi: 10.1016/j.ijporl.2023.111638. Epub 2023 Jun 17. Int J Pediatr Otorhinolaryngol. 2023. PMID: 37352592
In addition to tongue-tie, abnormal frenulums such as the labial frenulum and buccal frenulum can cause lip-tie and cheek-tie, respectively. ...The findings highlight the need for more comprehensive research and attention to lip-tie and cheek-tie …
In addition to tongue-tie, abnormal frenulums such as the labial frenulum and buccal frenulum can cause lip-tie and cheek-t …
Tie-1: A potential target for anti-angiogenesis therapy.
Yang P, Chen N, Jia JH, Gao XJ, Li SH, Cai J, Wang Z. Yang P, et al. J Huazhong Univ Sci Technolog Med Sci. 2015 Oct;35(5):615-622. doi: 10.1007/s11596-015-1479-1. Epub 2015 Oct 22. J Huazhong Univ Sci Technolog Med Sci. 2015. PMID: 26489611 Review.
Since all Angs are able to bind to Tie-2 but none binds to Tie-1, the function of Tie-2 and its ligands have captured attention. ...It is required for maintaining vascular endothelial cell integrity and survival during murine embryo development and in adult a …
Since all Angs are able to bind to Tie-2 but none binds to Tie-1, the function of Tie-2 and its ligands have captured a …
Role of Angiopoietin-Tie axis in vascular and lymphatic systems and therapeutic interventions.
Wang R, Yang M, Jiang L, Huang M. Wang R, et al. Pharmacol Res. 2022 Aug;182:106331. doi: 10.1016/j.phrs.2022.106331. Epub 2022 Jun 27. Pharmacol Res. 2022. PMID: 35772646 Review.
The Ang-Tie axis is involved in regulating angiogenesis, vascular remodeling, vascular permeability, and inflammation to maintain vascular quiescence. ...Given recent advances in the Ang-Tie axis in the vascular and lymphatic systems, this review focuses on the mult …
The Ang-Tie axis is involved in regulating angiogenesis, vascular remodeling, vascular permeability, and inflammation to maintain vas …
Angiopoietin-Tie signaling in kidney diseases: an updated review.
He FF, Zhang D, Chen Q, Zhao Y, Wu L, Li ZQ, Zhang C, Jiang ZH, Wang YM. He FF, et al. FEBS Lett. 2019 Oct;593(19):2706-2715. doi: 10.1002/1873-3468.13568. Epub 2019 Aug 11. FEBS Lett. 2019. PMID: 31380564 Free article. Review.
Angiopoietins (Angs) are a family of vascular growth factors that share multiple cellular functions related to cell survival, proliferation, and migration. Angs play physiological and pathological roles through the Tie tyrosine kinase receptors. The Ang-Tie signalin …
Angiopoietins (Angs) are a family of vascular growth factors that share multiple cellular functions related to cell survival, proliferation, …
Tongue tie: the evidence for frenotomy.
Brookes A, Bowley DM. Brookes A, et al. Early Hum Dev. 2014 Nov;90(11):765-8. doi: 10.1016/j.earlhumdev.2014.08.021. Epub 2014 Sep 23. Early Hum Dev. 2014. PMID: 25258296 Review.
Tongue tie or ankyloglossia is a congenital variation characterised by a short lingual frenulum which may result in restriction of tongue movement and thus impact on function. ...For the majority of mothers, frenotomy appears to enhance maintenance of breastfeeding. Tongue …
Tongue tie or ankyloglossia is a congenital variation characterised by a short lingual frenulum which may result in restriction of to …
11,346 results
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