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Simultaneous activation of Kras-Akt and Notch pathways induces extrahepatic biliary cancer via the mTORC1 pathway.
Namikawa M, Fukuda A, Mizukoshi K, Iwane K, Kawai M, Yamakawa G, Omatsu M, Sono M, Masuda T, Araki O, Nagao M, Yoshikawa T, Ogawa S, Hiramatsu Y, Muta Y, Tsuda M, Maruno T, Nakanishi Y, Tsuruyama T, Taura K, Hatano E, Seno H. Namikawa M, et al. Among authors: ogawa s. J Pathol. 2023 Aug;260(4):478-492. doi: 10.1002/path.6139. Epub 2023 Jun 13. J Pathol. 2023. PMID: 37310065
ARID1A Maintains Differentiation of Pancreatic Ductal Cells and Inhibits Development of Pancreatic Ductal Adenocarcinoma in Mice.
Kimura Y, Fukuda A, Ogawa S, Maruno T, Takada Y, Tsuda M, Hiramatsu Y, Araki O, Nagao M, Yoshikawa T, Ikuta K, Yoshioka T, Wang Z, Akiyama H, Wright CV, Takaori K, Uemoto S, Chiba T, Seno H. Kimura Y, et al. Among authors: ogawa s. Gastroenterology. 2018 Jul;155(1):194-209.e2. doi: 10.1053/j.gastro.2018.03.039. Epub 2018 Mar 29. Gastroenterology. 2018. PMID: 29604291
The BRG1/SOX9 axis is critical for acinar cell-derived pancreatic tumorigenesis.
Tsuda M, Fukuda A, Roy N, Hiramatsu Y, Leonhardt L, Kakiuchi N, Hoyer K, Ogawa S, Goto N, Ikuta K, Kimura Y, Matsumoto Y, Takada Y, Yoshioka T, Maruno T, Yamaga Y, Kim GE, Akiyama H, Ogawa S, Wright CV, Saur D, Takaori K, Uemoto S, Hebrok M, Chiba T, Seno H. Tsuda M, et al. Among authors: ogawa s. J Clin Invest. 2018 Aug 1;128(8):3475-3489. doi: 10.1172/JCI94287. Epub 2018 Jul 16. J Clin Invest. 2018. PMID: 30010625 Free PMC article.
Arid1a is essential for intestinal stem cells through Sox9 regulation.
Hiramatsu Y, Fukuda A, Ogawa S, Goto N, Ikuta K, Tsuda M, Matsumoto Y, Kimura Y, Yoshioka T, Takada Y, Maruno T, Hanyu Y, Tsuruyama T, Wang Z, Akiyama H, Takaishi S, Miyoshi H, Taketo MM, Chiba T, Seno H. Hiramatsu Y, et al. Among authors: ogawa s. Proc Natl Acad Sci U S A. 2019 Jan 29;116(5):1704-1713. doi: 10.1073/pnas.1804858116. Epub 2019 Jan 11. Proc Natl Acad Sci U S A. 2019. PMID: 30635419 Free PMC article.
Bmi1 marks gastric stem cells located in the isthmus in mice.
Yoshioka T, Fukuda A, Araki O, Ogawa S, Hanyu Y, Matsumoto Y, Yamaga Y, Nakanishi Y, Kawada K, Sakai Y, Chiba T, Seno H. Yoshioka T, et al. Among authors: ogawa s. J Pathol. 2019 Jun;248(2):179-190. doi: 10.1002/path.5244. Epub 2019 Feb 20. J Pathol. 2019. PMID: 30689202
Epithelial EP4 plays an essential role in maintaining homeostasis in colon.
Matsumoto Y, Nakanishi Y, Yoshioka T, Yamaga Y, Masuda T, Fukunaga Y, Sono M, Yoshikawa T, Nagao M, Araki O, Ogawa S, Goto N, Hiramatsu Y, Breyer RM, Fukuda A, Seno H. Matsumoto Y, et al. Among authors: ogawa s. Sci Rep. 2019 Oct 23;9(1):15244. doi: 10.1038/s41598-019-51639-2. Sci Rep. 2019. PMID: 31645712 Free PMC article.
SETDB1 Inhibits p53-Mediated Apoptosis and Is Required for Formation of Pancreatic Ductal Adenocarcinomas in Mice.
Ogawa S, Fukuda A, Matsumoto Y, Hanyu Y, Sono M, Fukunaga Y, Masuda T, Araki O, Nagao M, Yoshikawa T, Goto N, Hiramatsu Y, Tsuda M, Maruno T, Nakanishi Y, Hussein MS, Tsuruyama T, Takaori K, Uemoto S, Seno H. Ogawa S, et al. Gastroenterology. 2020 Aug;159(2):682-696.e13. doi: 10.1053/j.gastro.2020.04.047. Epub 2020 Apr 28. Gastroenterology. 2020. PMID: 32360551 Free article.
Brg1 is required to maintain colorectal cancer stem cells.
Yoshikawa T, Fukuda A, Omatsu M, Namikawa M, Sono M, Fukunaga Y, Masuda T, Araki O, Nagao M, Ogawa S, Masuo K, Goto N, Hiramatsu Y, Muta Y, Tsuda M, Maruno T, Nakanishi Y, Kawada K, Takaishi S, Seno H. Yoshikawa T, et al. Among authors: ogawa s. J Pathol. 2021 Nov;255(3):257-269. doi: 10.1002/path.5759. Epub 2021 Aug 20. J Pathol. 2021. PMID: 34415580
4,153 results