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Pyridone 6, a pan-Janus-activated kinase inhibitor, suppresses osteoclast formation and bone resorption through down-regulation of receptor activator of nuclear factor-kappaB (NF-kappaB) ligand (RANKL)-induced c-Fos and nuclear factor of activated T cells (NFAT) c1 expression.
Kwak HB, Kim HS, Lee MS, Kim KJ, Choi EY, Choi MK, Kim JJ, Cho HJ, Kim JW, Bae JM, Kim YK, Park BH, Ha H, Chun CH, Oh J. Kwak HB, et al. Among authors: oh j. Biol Pharm Bull. 2009 Jan;32(1):45-50. doi: 10.1248/bpb.32.45. Biol Pharm Bull. 2009. PMID: 19122279 Free article.
Risedronate directly inhibits osteoclast differentiation and inflammatory bone loss.
Kwak HB, Kim JY, Kim KJ, Choi MK, Kim JJ, Kim KM, Shin YI, Lee MS, Kim HS, Kim JW, Chun CH, Cho HJ, Hong GY, Juhng SK, Yoon KH, Park BH, Bae JM, Han JK, Oh J. Kwak HB, et al. Among authors: oh j. Biol Pharm Bull. 2009 Jul;32(7):1193-8. doi: 10.1248/bpb.32.1193. Biol Pharm Bull. 2009. PMID: 19571384 Free article.
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