Ohno K - Search Results

1

Effect of YM928, a novel AMPA receptor antagonist, on seizures in EL mice and kainate-induced seizures in rats.

Yamashita H, Ohno K, Amada Y, Inami H, Shishikura J, Sakamoto S, Okada M, Yamaguchi T. Yamashita H, et al. Among authors: ohno k. Naunyn Schmiedebergs Arch Pharmacol. 2004 Aug;370(2):99-105. doi: 10.1007/s00210-004-0953-2. Epub 2004 Jul 31. Naunyn Schmiedebergs Arch Pharmacol. 2004. PMID: 15322731

2

Functional characterization of YM928, a novel moncompetitive alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist.

Ohno K, Tsutsumi R, Matsumoto N, Yamashita H, Amada Y, Shishikura J, Yatsugi HI, Okada M, Sakamoto S, Yamaguchi T. Ohno K, et al. J Pharmacol Exp Ther. 2003 Jul;306(1):66-72. doi: 10.1124/jpet.103.049973. Epub 2003 Mar 26. J Pharmacol Exp Ther. 2003. PMID: 12660313

3

Effects of 2-[N-(4-chlorophenyl)-N-methylamino]-4H-pyrido[3.2-e]-1,3-thiazin-4-one (YM928), an orally active alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor antagonist, in models of generalized epileptic seizure in mice and rats.

Yamashita H, Ohno K, Amada Y, Hattori H, Ozawa-Funatsu Y, Toya T, Inami H, Shishikura J, Sakamoto S, Okada M, Yamaguchi T. Yamashita H, et al. Among authors: ohno k. J Pharmacol Exp Ther. 2004 Jan;308(1):127-33. doi: 10.1124/jpet.103.058495. Epub 2003 Oct 20. J Pharmacol Exp Ther. 2004. PMID: 14569061

4

Suppression of fully kindled seizure and retardation of kindling acquisition by YM928 in the rat kindling model of epilepsy.

Yamashita H, Ohno K, Inami H, Shishikura J, Sakamoto S, Okada M, Yamaguchi T. Yamashita H, et al. Among authors: ohno k. Eur J Pharmacol. 2004 Jun 28;494(2-3):147-54. doi: 10.1016/j.ejphar.2004.04.052. Eur J Pharmacol. 2004. PMID: 15212968

5

Synthesis, structure-activity relationships, and anticonvulsant activities of 2-amino-4H-pyrido[3,2-e][1,3]thiazin-4-one derivatives as orally active AMPA receptor antagonists.

Inami H, Shishikura J, Yasunaga T, Ohno K, Yamashita H, Kato K, Sakamoto S. Inami H, et al. Among authors: ohno k. Bioorg Med Chem. 2015 Apr 15;23(8):1788-99. doi: 10.1016/j.bmc.2015.02.033. Epub 2015 Feb 25. Bioorg Med Chem. 2015. PMID: 25792143

6

Synthesis and Pharmacological Evaluation of 3-[(4-Oxo-4H-pyrido[3,2-e][1,3]thiazin-2-yl)(phenyl)amino]propanenitrile Derivatives as Orally Active AMPA Receptor Antagonists.

Inami H, Shishikura JI, Yasunaga T, Hirano M, Kimura T, Yamashita H, Ohno K, Sakamoto S. Inami H, et al. Among authors: ohno k. Chem Pharm Bull (Tokyo). 2019;67(7):699-706. doi: 10.1248/cpb.c18-00977. Chem Pharm Bull (Tokyo). 2019. PMID: 31257325 Free article.

7

The AMPA-receptor antagonist YM90K reduces AMPA receptor-mediated excitotoxicity in rat hippocampal cultures.

Ohno K, Okada M, Tsutsumi R, Sakamoto S, Yamaguchi T. Ohno K, et al. Jpn J Pharmacol. 1998 Jan;76(1):105-8. doi: 10.1254/jjp.76.105. Jpn J Pharmacol. 1998. PMID: 9517411 Free article.

8

In-vitro characterization of YM872, a selective, potent and highly water-soluble alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate receptor antagonist.

Kohara A, Okada M, Tsutsumi R, Ohno K, Takahashi M, Shimizu-Sasamata M, Shishikura J, Inami H, Sakamoto S, Yamaguchi T. Kohara A, et al. Among authors: ohno k. J Pharm Pharmacol. 1998 Jul;50(7):795-801. doi: 10.1111/j.2042-7158.1998.tb07142.x. J Pharm Pharmacol. 1998. PMID: 9720630

9

Kainate excitotoxicity is mediated by AMPA- but not kainate-preferring receptors in embryonic rat hippocampal cultures.

Ohno K, Okada M, Tsutsumi R, Kohara A, Yamaguchi T. Ohno K, et al. Neurochem Int. 1997 Nov;31(5):715-22. doi: 10.1016/s0197-0186(97)00011-9. Neurochem Int. 1997. PMID: 9364457

10

Characterization of cyclothiazide-enhanced kainate excitotoxicity in rat hippocampal cultures.

Ohno K, Okada M, Tsutsumi R, Matsumoto N, Yamaguchi T. Ohno K, et al. Neurochem Int. 1998 Mar;32(3):265-71. doi: 10.1016/s0197-0186(97)00098-3. Neurochem Int. 1998. PMID: 9587920

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