Ohta M - Search Results

1

Synthesis and biological evaluation of 4-morpholino-2-phenylquinazolines and related derivatives as novel PI3 kinase p110alpha inhibitors.

Hayakawa M, Kaizawa H, Moritomo H, Koizumi T, Ohishi T, Okada M, Ohta M, Tsukamoto S, Parker P, Workman P, Waterfield M. Hayakawa M, et al. Among authors: ohta m. Bioorg Med Chem. 2006 Oct 15;14(20):6847-58. doi: 10.1016/j.bmc.2006.06.046. Epub 2006 Jul 11. Bioorg Med Chem. 2006. PMID: 16837202

2

Synthetic studies on novel Syk inhibitors. Part 1: Synthesis and structure-activity relationships of pyrimidine-5-carboxamide derivatives.

Hisamichi H, Naito R, Toyoshima A, Kawano N, Ichikawa A, Orita A, Orita M, Hamada N, Takeuchi M, Ohta M, Tsukamoto S. Hisamichi H, et al. Among authors: ohta m. Bioorg Med Chem. 2005 Aug 15;13(16):4936-51. doi: 10.1016/j.bmc.2005.05.033. Bioorg Med Chem. 2005. PMID: 15990316

3

Novel potent and selective calcium-release-activated calcium (CRAC) channel inhibitors. Part 1: synthesis and inhibitory activity of 5-(1-methyl-3-trifluoromethyl-1H-pyrazol-5-yl)-2-thiophenecarboxamides.

Yonetoku Y, Kubota H, Okamoto Y, Toyoshima A, Funatsu M, Ishikawa J, Takeuchi M, Ohta M, Tsukamoto S. Yonetoku Y, et al. Among authors: ohta m. Bioorg Med Chem. 2006 Jul 15;14(14):4750-60. doi: 10.1016/j.bmc.2006.03.024. Epub 2006 Mar 31. Bioorg Med Chem. 2006. PMID: 16580212

4

Novel potent and selective calcium-release-activated calcium (CRAC) channel inhibitors. Part 2: Synthesis and inhibitory activity of aryl-3-trifluoromethylpyrazoles.

Yonetoku Y, Kubota H, Okamoto Y, Ishikawa J, Takeuchi M, Ohta M, Tsukamoto S. Yonetoku Y, et al. Among authors: ohta m. Bioorg Med Chem. 2006 Aug 1;14(15):5370-83. doi: 10.1016/j.bmc.2006.03.039. Epub 2006 Apr 17. Bioorg Med Chem. 2006. PMID: 16616503

5

Synthesis and biological evaluation of imidazo[1,2-a]pyridine derivatives as novel PI3 kinase p110alpha inhibitors.

Hayakawa M, Kaizawa H, Kawaguchi K, Ishikawa N, Koizumi T, Ohishi T, Yamano M, Okada M, Ohta M, Tsukamoto S, Raynaud FI, Waterfield MD, Parker P, Workman P. Hayakawa M, et al. Among authors: ohta m. Bioorg Med Chem. 2007 Jan 1;15(1):403-12. doi: 10.1016/j.bmc.2006.09.047. Epub 2006 Oct 16. Bioorg Med Chem. 2007. PMID: 17049248

6

Design, synthesis and biological activity of selective and orally available TF/FVIIa complex inhibitors containing non-amidine P1 ligands.

Miura M, Seki N, Koike T, Ishihara T, Niimi T, Hirayama F, Shigenaga T, Sakai-Moritani Y, Tagawa A, Kawasaki T, Sakamoto S, Okada M, Ohta M, Tsukamoto S. Miura M, et al. Among authors: ohta m. Bioorg Med Chem. 2007 Jan 1;15(1):160-73. doi: 10.1016/j.bmc.2006.09.071. Epub 2006 Oct 4. Bioorg Med Chem. 2007. PMID: 17064913

7

Synthesis and evaluation of 2-{[2-(4-hydroxyphenyl)-ethyl]amino}pyrimidine-5-carboxamide derivatives as novel STAT6 inhibitors.

Nagashima S, Yokota M, Nakai E, Kuromitsu S, Ohga K, Takeuchi M, Tsukamoto S, Ohta M. Nagashima S, et al. Among authors: ohta m. Bioorg Med Chem. 2007 Jan 15;15(2):1044-55. doi: 10.1016/j.bmc.2006.10.015. Epub 2006 Oct 27. Bioorg Med Chem. 2007. PMID: 17071093

8

Synthesis and biological evaluation of pyrido[3',2':4,5]furo[3,2-d]pyrimidine derivatives as novel PI3 kinase p110alpha inhibitors.

Hayakawa M, Kaizawa H, Moritomo H, Koizumi T, Ohishi T, Yamano M, Okada M, Ohta M, Tsukamoto S, Raynaud FI, Workman P, Waterfield MD, Parker P. Hayakawa M, et al. Among authors: ohta m. Bioorg Med Chem Lett. 2007 May 1;17(9):2438-42. doi: 10.1016/j.bmcl.2007.02.032. Epub 2007 Feb 15. Bioorg Med Chem Lett. 2007. PMID: 17339109

9

Synthesis and biological evaluation of sulfonylhydrazone-substituted imidazo[1,2-a]pyridines as novel PI3 kinase p110alpha inhibitors.

Hayakawa M, Kawaguchi K, Kaizawa H, Koizumi T, Ohishi T, Yamano M, Okada M, Ohta M, Tsukamoto S, Raynaud FI, Parker P, Workman P, Waterfield MD. Hayakawa M, et al. Among authors: ohta m. Bioorg Med Chem. 2007 Sep 1;15(17):5837-44. doi: 10.1016/j.bmc.2007.05.070. Epub 2007 Jun 6. Bioorg Med Chem. 2007. PMID: 17601739

10

Synthesis of 5-chloro-N-aryl-1H-indole-2-carboxamide derivatives as inhibitors of human liver glycogen phosphorylase a.

Onda K, Suzuki T, Shiraki R, Yonetoku Y, Negoro K, Momose K, Katayama N, Orita M, Yamaguchi T, Ohta M, Tsukamoto S. Onda K, et al. Among authors: ohta m. Bioorg Med Chem. 2008 May 15;16(10):5452-64. doi: 10.1016/j.bmc.2008.04.010. Epub 2008 Apr 11. Bioorg Med Chem. 2008. PMID: 18434170

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