Okuma M - Search Results

1

Defective signal transduction induced by thromboxane A2 in a patient with a mild bleeding disorder: impaired phospholipase C activation despite normal phospholipase A2 activation.

Fuse I, Mito M, Hattori A, Higuchi W, Shibata A, Ushikubi F, Okuma M, Yahata K. Fuse I, et al. Among authors: okuma m. Blood. 1993 Feb 15;81(4):994-1000. Blood. 1993. PMID: 8428006 Free article.

2

Arg60 to Leu mutation of the human thromboxane A2 receptor in a dominantly inherited bleeding disorder.

Hirata T, Kakizuka A, Ushikubi F, Fuse I, Okuma M, Narumiya S. Hirata T, et al. Among authors: okuma m. J Clin Invest. 1994 Oct;94(4):1662-7. doi: 10.1172/JCI117510. J Clin Invest. 1994. PMID: 7929844 Free PMC article.

3

Molecular characterization of a dominantly inherited bleeding disorder with impaired platelet responses to thromboxane A2.

Okuma M, Hirata T, Ushikubi F, Kakizuka A, Narumiya S. Okuma M, et al. Pol J Pharmacol. 1996 Jan-Feb;48(1):77-82. Pol J Pharmacol. 1996. PMID: 9112632

4

Analysis of the defective signal transduction mechanism through the platelet thromboxane A2 receptor in a patient with polycythemia vera.

Ushikubi F, Ishibashi T, Narumiya S, Okuma M. Ushikubi F, et al. Among authors: okuma m. Thromb Haemost. 1992 Jan 23;67(1):144-6. Thromb Haemost. 1992. PMID: 1535462

5

Deficient elevation of the cytoplasmic calcium ion concentration by epinephrine in epinephrine-insensitive platelets of patients with myeloproliferative disorders.

Ushikubi F, Okuma M, Ishibashi T, Narumiya S, Uchino H. Ushikubi F, et al. Among authors: okuma m. Am J Hematol. 1990 Feb;33(2):96-100. doi: 10.1002/ajh.2830330205. Am J Hematol. 1990. PMID: 2154092

6

A novel platelet aggregating factor found in a patient with defective collagen-induced platelet aggregation and autoimmune thrombocytopenia.

Sugiyama T, Okuma M, Ushikubi F, Sensaki S, Kanaji K, Uchino H. Sugiyama T, et al. Among authors: okuma m. Blood. 1987 Jun;69(6):1712-20. Blood. 1987. PMID: 3580576 Free article.

7

Two thromboxane A2 receptor isoforms in human platelets. Opposite coupling to adenylyl cyclase with different sensitivity to Arg60 to Leu mutation.

Hirata T, Ushikubi F, Kakizuka A, Okuma M, Narumiya S. Hirata T, et al. Among authors: okuma m. J Clin Invest. 1996 Feb 15;97(4):949-56. doi: 10.1172/JCI118518. J Clin Invest. 1996. PMID: 8613548 Free PMC article.

The Arg60 to Leu mutant of TXR alpha, which has been shown to impair PLC activation (Hirata, T., A. Kakizuka, F. Ushikubi, I. Fuse, M. Okuma, and S. Narumiya. 1994. J. Clin. Invest. 94: 1662-1667), also impairs adenylyl cyclase stimulation, whereas that of TXR beta …

The Arg60 to Leu mutant of TXR alpha, which has been shown to impair PLC activation (Hirata, T., A. Kakizuka, F. Ushikubi, I. Fuse, M …

8

Expression of thromboxane A2 receptor in cultured human erythroleukemia cells and its induction by 12-O-tetradecanoylphorbol-13-acetate.

Nakajima M, Yamamoto M, Ushikubi F, Okuma M, Fujiwara M, Narumiya S. Nakajima M, et al. Among authors: okuma m. Biochem Biophys Res Commun. 1989 Feb 15;158(3):958-65. doi: 10.1016/0006-291x(89)92815-5. Biochem Biophys Res Commun. 1989. PMID: 2522003

9

Purification of the thromboxane A2/prostaglandin H2 receptor from human blood platelets.

Ushikubi F, Nakajima M, Hirata M, Okuma M, Fujiwara M, Narumiya S. Ushikubi F, et al. Among authors: okuma m. J Biol Chem. 1989 Oct 5;264(28):16496-501. J Biol Chem. 1989. PMID: 2528545 Free article.

10

Hemorrhagic thrombocytopathy with platelet thromboxane A2 receptor abnormality: defective signal transduction with normal binding activity.

Ushikubi F, Okuma M, Kanaji K, Sugiyama T, Ogorochi T, Narumiya S, Uchino H. Ushikubi F, et al. Among authors: okuma m. Thromb Haemost. 1987 Apr 7;57(2):158-64. Thromb Haemost. 1987. PMID: 2955539

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