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A p53-dependent response limits the viability of mammalian haploid cells.
Olbrich T, Mayor-Ruiz C, Vega-Sendino M, Gomez C, Ortega S, Ruiz S, Fernandez-Capetillo O. Olbrich T, et al. Proc Natl Acad Sci U S A. 2017 Aug 29;114(35):9367-9372. doi: 10.1073/pnas.1705133114. Epub 2017 Aug 14. Proc Natl Acad Sci U S A. 2017. PMID: 28808015 Free PMC article.
ERF deletion rescues RAS deficiency in mouse embryonic stem cells.
Mayor-Ruiz C, Olbrich T, Drosten M, Lecona E, Vega-Sendino M, Ortega S, Dominguez O, Barbacid M, Ruiz S, Fernandez-Capetillo O. Mayor-Ruiz C, et al. Among authors: olbrich t. Genes Dev. 2018 Apr 1;32(7-8):568-576. doi: 10.1101/gad.310086.117. Epub 2018 Apr 12. Genes Dev. 2018. PMID: 29650524 Free PMC article.
CTCF is a barrier for 2C-like reprogramming.
Olbrich T, Vega-Sendino M, Tillo D, Wu W, Zolnerowich N, Pavani R, Tran AD, Domingo CN, Franco M, Markiewicz-Potoczny M, Pegoraro G, FitzGerald PC, Kruhlak MJ, Lazzerini-Denchi E, Nora EP, Nussenzweig A, Ruiz S. Olbrich T, et al. Nat Commun. 2021 Aug 11;12(1):4856. doi: 10.1038/s41467-021-25072-x. Nat Commun. 2021. PMID: 34381034 Free PMC article.
TRF2-mediated telomere protection is dispensable in pluripotent stem cells.
Markiewicz-Potoczny M, Lobanova A, Loeb AM, Kirak O, Olbrich T, Ruiz S, Lazzerini Denchi E. Markiewicz-Potoczny M, et al. Among authors: olbrich t. Nature. 2021 Jan;589(7840):110-115. doi: 10.1038/s41586-020-2959-4. Epub 2020 Nov 25. Nature. 2021. PMID: 33239785 Free PMC article.
The homeobox transcription factor DUXBL controls exit from totipotency.
Vega-Sendino M, Lüttmann FF, Olbrich T, Chen Y, Kuenne C, Stein P, Tillo D, Carey GI, Zhong J, Savy V, Radonova L, Lu T, Saykali B, Kim KP, Domingo CN, Schüler L, Günther S, Bentsen M, Bosnakovski D, Schöler H, Kyba M, Maity TK, Jenkins LM, Looso M, Williams CJ, Kim J, Ruiz S. Vega-Sendino M, et al. Among authors: olbrich t. Nat Genet. 2024 Apr;56(4):697-709. doi: 10.1038/s41588-024-01692-z. Epub 2024 Mar 20. Nat Genet. 2024. PMID: 38509386
Development of an automated manufacturing process for large-scale production of autologous T cell therapies.
Francis N, Braun M, Neagle S, Peiffer S, Bohn A, Rosenthal A, Olbrich T, Lollies S, Ilsmann K, Hauck C, Gerstmayer B, Weber S, Kirkpatrick A. Francis N, et al. Among authors: olbrich t. Mol Ther Methods Clin Dev. 2023 Sep 16;31:101114. doi: 10.1016/j.omtm.2023.101114. eCollection 2023 Dec 14. Mol Ther Methods Clin Dev. 2023. PMID: 37790245 Free PMC article.
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