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Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases.
Guo RT, Cao R, Liang PH, Ko TP, Chang TH, Hudock MP, Jeng WY, Chen CK, Zhang Y, Song Y, Kuo CJ, Yin F, Oldfield E, Wang AH. Guo RT, et al. Among authors: oldfield e. Proc Natl Acad Sci U S A. 2007 Jun 12;104(24):10022-7. doi: 10.1073/pnas.0702254104. Epub 2007 May 29. Proc Natl Acad Sci U S A. 2007. PMID: 17535895 Free PMC article.
Activity of sulfonium bisphosphonates on tumor cell lines.
Zhang Y, Hudock MP, Krysiak K, Cao R, Bergan K, Yin F, Leon A, Oldfield E. Zhang Y, et al. Among authors: oldfield e. J Med Chem. 2007 Nov 29;50(24):6067-79. doi: 10.1021/jm700991k. Epub 2007 Oct 27. J Med Chem. 2007. PMID: 17963374
Lipophilic bisphosphonates as dual farnesyl/geranylgeranyl diphosphate synthase inhibitors: an X-ray and NMR investigation.
Zhang Y, Cao R, Yin F, Hudock MP, Guo RT, Krysiak K, Mukherjee S, Gao YG, Robinson H, Song Y, No JH, Bergan K, Leon A, Cass L, Goddard A, Chang TK, Lin FY, Van Beek E, Papapoulos S, Wang AH, Kubo T, Ochi M, Mukkamala D, Oldfield E. Zhang Y, et al. Among authors: oldfield e. J Am Chem Soc. 2009 Apr 15;131(14):5153-62. doi: 10.1021/ja808285e. J Am Chem Soc. 2009. PMID: 19309137 Free PMC article.
Mechanism of action and inhibition of dehydrosqualene synthase.
Lin FY, Liu CI, Liu YL, Zhang Y, Wang K, Jeng WY, Ko TP, Cao R, Wang AH, Oldfield E. Lin FY, et al. Among authors: oldfield e. Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21337-42. doi: 10.1073/pnas.1010907107. Epub 2010 Nov 23. Proc Natl Acad Sci U S A. 2010. PMID: 21098670 Free PMC article.
Squalene synthase as a target for Chagas disease therapeutics.
Shang N, Li Q, Ko TP, Chan HC, Li J, Zheng Y, Huang CH, Ren F, Chen CC, Zhu Z, Galizzi M, Li ZH, Rodrigues-Poveda CA, Gonzalez-Pacanowska D, Veiga-Santos P, de Carvalho TM, de Souza W, Urbina JA, Wang AH, Docampo R, Li K, Liu YL, Oldfield E, Guo RT. Shang N, et al. Among authors: oldfield e. PLoS Pathog. 2014 May 1;10(5):e1004114. doi: 10.1371/journal.ppat.1004114. eCollection 2014 May. PLoS Pathog. 2014. PMID: 24789335 Free PMC article.
927 results