Olesen PH - Search Results

1

Xanomeline: a novel muscarinic receptor agonist with functional selectivity for M1 receptors.

Shannon HE, Bymaster FP, Calligaro DO, Greenwood B, Mitch CH, Sawyer BD, Ward JS, Wong DT, Olesen PH, Sheardown MJ, Swedberg MD, Suzdak PD, Sauerberg P. Shannon HE, et al. Among authors: olesen ph. J Pharmacol Exp Ther. 1994 Apr;269(1):271-81. J Pharmacol Exp Ther. 1994. PMID: 7909557

2

Novel functional M1 selective muscarinic agonists. 2. Synthesis and structure-activity relationships of 3-pyrazinyl-1,2,5,6-tetrahydro-1-methylpyridines. Construction of a molecular model for the M1 pharmacophore.

Ward JS, Merritt L, Klimkowski VJ, Lamb ML, Mitch CH, Bymaster FP, Sawyer B, Shannon HE, Olesen PH, Honoré T, et al. Ward JS, et al. Among authors: olesen ph. J Med Chem. 1992 Oct 30;35(22):4011-9. doi: 10.1021/jm00100a005. J Med Chem. 1992. PMID: 1433209

3

Functionally selective M1 muscarinic agonists. 3. Side chains and azacycles contributing to functional muscarinic selectivity among pyrazinylazacycles.

Ward JS, Merritt L, Calligaro DO, Bymaster FP, Shannon HE, Sawyer BD, Mitch CH, Deeter JB, Peters SC, Sheardown MJ, Olesen PH, Swedberg MD, Sauerberg P. Ward JS, et al. Among authors: olesen ph. J Med Chem. 1995 Sep 1;38(18):3469-81. doi: 10.1021/jm00018a007. J Med Chem. 1995. PMID: 7658434

4

Neurochemical effects of the M1 muscarinic agonist xanomeline (LY246708/NNC11-0232).

Bymaster FP, Wong DT, Mitch CH, Ward JS, Calligaro DO, Schoepp DD, Shannon HE, Sheardown MJ, Olesen PH, Suzdak PD, Swedberg MD, Sauerberg P. Bymaster FP, et al. Among authors: olesen ph. J Pharmacol Exp Ther. 1994 Apr;269(1):282-9. J Pharmacol Exp Ther. 1994. PMID: 7909558

5

In vivo pharmacology of butylthio[2.2.2] (LY297802 / NNC11-1053), an orally acting antinociceptive muscarinic agonist.

Shannon HE, Womer DE, Bymaster FP, Calligaro DO, DeLapp NC, Mitch CH, Ward JS, Whitesitt CA, Swedberg MD, Sheardown MJ, Fink-Jensen A, Olesen PH, Rimvall K, Sauerberg P. Shannon HE, et al. Among authors: olesen ph. Life Sci. 1997;60(13-14):969-76. doi: 10.1016/s0024-3205(97)00036-2. Life Sci. 1997. PMID: 9121363 Review.

6

M1 receptor agonist activity is not a requirement for muscarinic antinociception.

Sheardown MJ, Shannon HE, Swedberg MD, Suzdak PD, Bymaster FP, Olesen PH, Mitch CH, Ward JS, Sauerberg P. Sheardown MJ, et al. Among authors: olesen ph. J Pharmacol Exp Ther. 1997 May;281(2):868-75. J Pharmacol Exp Ther. 1997. PMID: 9152396

7

Butylthio[2.2.2] (NNC 11-1053/LY297802): an orally active muscarinic agonist analgesic.

Swedberg MD, Sheardown MJ, Sauerberg P, Olesen PH, Suzdak PD, Hansen KT, Bymaster FP, Ward JS, Mitch CH, Calligaro DO, Delapp NW, Shannon HE. Swedberg MD, et al. Among authors: olesen ph. J Pharmacol Exp Ther. 1997 May;281(2):876-83. J Pharmacol Exp Ther. 1997. PMID: 9152397

8

Pharmacology of butylthio[2.2.2] (LY297802/NNC11-1053): a novel analgesic with mixed muscarinic receptor agonist and antagonist activity.

Shannon HE, Sheardown MJ, Bymaster FP, Calligaro DO, Delapp NW, Gidda J, Mitch CH, Sawyer BD, Stengel PW, Ward JS, Wong DT, Olesen PH, Suzdak PD, Sauerberg P, Swedberg MD. Shannon HE, et al. Among authors: olesen ph. J Pharmacol Exp Ther. 1997 May;281(2):884-94. J Pharmacol Exp Ther. 1997. PMID: 9152398

9

1,2,5-Thiadiazole analogues of aceclidine as potent m1 muscarinic agonists.

Ward JS, Merritt L, Calligaro DO, Bymaster FP, Shannon HE, Mitch CH, Whitesitt C, Brunsting D, Sheardown MJ, Olesen PH, Swedberg MD, Jeppesen L, Sauerberg P. Ward JS, et al. Among authors: olesen ph. J Med Chem. 1998 Jan 29;41(3):379-92. doi: 10.1021/jm970125n. J Med Chem. 1998. PMID: 9464368

10

Unexpected antipsychotic-like activity with the muscarinic receptor ligand (5R,6R)6-(3-propylthio-1,2,5-thiadiazol-4-yl)-1-azabicyclo[3.2.1]octane.

Bymaster FP, Shannon HE, Rasmussen K, Delapp NW, Mitch CH, Ward JS, Calligaro DO, Ludvigsen TS, Sheardown MJ, Olesen PH, Swedberg MD, Sauerberg P, Fink-Jensen A. Bymaster FP, et al. Among authors: olesen ph. Eur J Pharmacol. 1998 Sep 4;356(2-3):109-19. doi: 10.1016/s0014-2999(98)00487-7. Eur J Pharmacol. 1998. PMID: 9774240

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