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Olmutinib Reverses Thioacetamide-Induced Cell Cycle Gene Alterations in Mice Liver and Kidney Tissues, While Wheat Germ Treatment Exhibits Limited Efficacy at Gene Level.
Zargar S, Wani TA, Alamery S, Yaseen F. Zargar S, et al. Medicina (Kaunas). 2024 Apr 16;60(4):639. doi: 10.3390/medicina60040639. Medicina (Kaunas). 2024. PMID: 38674285 Free PMC article.
This study investigated the impact of olmutinib and wheat germ oil (WGO) on Thioacetamide (TAA)-induced gene alterations in mice liver and kidney tissues. Materials and Methods: Adult male C57BL/6 mice were exposed to 0.3% TAA in drinking water for 14 days, followed by the …
This study investigated the impact of olmutinib and wheat germ oil (WGO) on Thioacetamide (TAA)-induced gene alterations in mice live …
Synthesis and initial in vitro evaluation of olmutinib derivatives as prospective imaging probe for non-small cell lung cancer.
Fawwaz M, Mishiro K, Arwansyah A, Nishii R, Ogawa K. Fawwaz M, et al. Bioimpacts. 2024;14(1):27774. doi: 10.34172/bi.2023.27774. Epub 2023 Aug 19. Bioimpacts. 2024. PMID: 38327635 Free PMC article.
INTRODUCTION: Imaging a non-small cell lung cancer (NSCLC) using radiolabeled tyrosine kinase inhibitors (TKIs) has attracted attention due to their unique interaction with the target epidermal growth factor receptor (EGFR). Olmutinib (OTB) is one of the third-generation E …
INTRODUCTION: Imaging a non-small cell lung cancer (NSCLC) using radiolabeled tyrosine kinase inhibitors (TKIs) has attracted attention due …
In Silico and In Vitro Exploration of Poziotinib and Olmutinib Synergy in Lung Cancer: Role of hsa-miR-7-5p in Regulating Apoptotic Pathway Marker Genes.
Alamery S, AlAjmi A, Wani TA, Zargar S. Alamery S, et al. Medicina (Kaunas). 2023 Oct 30;59(11):1923. doi: 10.3390/medicina59111923. Medicina (Kaunas). 2023. PMID: 38003971 Free PMC article.
Methods: A combined targeted therapy involving olmutinib and poziotinib was investigated for its impact on the apoptotic pathway in A549 cells. ...A549 cells were treated with varying concentrations (1, 2.5, and 5 muM) of poziotinib, olmutinib, and their combination …
Methods: A combined targeted therapy involving olmutinib and poziotinib was investigated for its impact on the apoptotic pathway in A …
The impacts of CYP3A4 genetic polymorphism and drug interactions on the metabolism of lurasidone.
Li Q, Wang J, Wang ZL, Shen Y, Zhou Q, Liu YN, Hu GX, Cai JP, Xu RA. Li Q, et al. Biomed Pharmacother. 2023 Dec;168:115833. doi: 10.1016/j.biopha.2023.115833. Epub 2023 Nov 6. Biomed Pharmacother. 2023. PMID: 37935069 Free article.
In vivo, Sprague-Dawley (SD) rats were applied to study the interaction between lurasidone and olmutinib. The concentrations of the analytes were detected by ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS). ...In conclusion, CYP3A4 genetic pol …
In vivo, Sprague-Dawley (SD) rats were applied to study the interaction between lurasidone and olmutinib. The concentrations of the a …
Learning from COVID-19: How drug hunters can prepare for the next pandemic.
Puhl AC, Lane TR, Ekins S. Puhl AC, et al. Drug Discov Today. 2023 Oct;28(10):103723. doi: 10.1016/j.drudis.2023.103723. Epub 2023 Jul 22. Drug Discov Today. 2023. PMID: 37482237
During this time, our very small company was able to contribute to antiviral drug discovery efforts through global collaborations with other researchers, which enabled the identification and repurposing of multiple molecules with activity against SARS-CoV-2 including pyronaridine …
During this time, our very small company was able to contribute to antiviral drug discovery efforts through global collaborations with other …
Discovery of PLpro and Mpro Inhibitors for SARS-CoV-2.
Puhl AC, Godoy AS, Noske GD, Nakamura AM, Gawriljuk VO, Fernandes RS, Oliva G, Ekins S. Puhl AC, et al. ACS Omega. 2023 Jun 14;8(25):22603-22612. doi: 10.1021/acsomega.3c01110. eCollection 2023 Jun 27. ACS Omega. 2023. PMID: 37387790 Free PMC article.
We additionally tested several kinase inhibitors and identified olmutinib (IC(50) = 0.54 0.04 muM), bosutinib (IC(50) = 4.23 0.28 muM), crizotinib (IC(50) = 3.81 0.04 muM), and dacominitinib (IC(50) = IC(50) 3.33 0.06 muM) as PL(pro) inhibitors for the first time. ...
We additionally tested several kinase inhibitors and identified olmutinib (IC(50) = 0.54 0.04 muM), bosutinib (IC(50) = 4.23 0.28 muM …
Evaluation of the Effect of Wheat Germ Oil and Olmutinib on the Thioacetamide-Induced Liver and Kidney Toxicity in Mice.
Alamery S, Zargar S, Yaseen F, Wani TA, Siyal A. Alamery S, et al. Life (Basel). 2022 Jun 15;12(6):900. doi: 10.3390/life12060900. Life (Basel). 2022. PMID: 35743930 Free PMC article.
In addition, Group II continued with TAA; Group III was given olmutinib (30 mg/kg), Group IV was given the wheat germ oil (WGO) (1400 mg/kg), and Group V was given (olmutinib (30 mg/kg) + WGO (1400 mg/kg)) for five days. The results suggested that olmutinib t …
In addition, Group II continued with TAA; Group III was given olmutinib (30 mg/kg), Group IV was given the wheat germ oil (WGO) (1400 …
Elucidation of the interaction mechanism of olmutinib with human alpha-1 acid glycoprotein: insights from spectroscopic and molecular modeling studies.
Kou SB, Li L, Zhang RJ, Shi JH, Jiang SL. Kou SB, et al. J Biomol Struct Dyn. 2023 Feb;41(2):525-537. doi: 10.1080/07391102.2021.2009373. Epub 2021 Nov 30. J Biomol Struct Dyn. 2023. PMID: 34844510
Olmutinib, the third-generation tyrosine kinase inhibitor, is applied in treating non-small cell lung cancer (NSCLC). The aim of this study is to elucidate the interaction mechanism of olmutinib with human alpha-1 acid glycoprotein (HAG), an important carrier protei …
Olmutinib, the third-generation tyrosine kinase inhibitor, is applied in treating non-small cell lung cancer (NSCLC). The aim of this …
Icotinib, Almonertinib, and Olmutinib: A 2D Similarity/Docking-Based Study to Predict the Potential Binding Modes and Interactions into EGFR.
Almalki FA, Shawky AM, Abdalla AN, Gouda AM. Almalki FA, et al. Molecules. 2021 Oct 24;26(21):6423. doi: 10.3390/molecules26216423. Molecules. 2021. PMID: 34770832 Free PMC article.
In the current study, a 2D similarity/docking-based study was used to predict the potential binding modes of icotinib, almonertinib, and olmutinib into EGFR. The similarity search of icotinib, almonertinib, and olmutinib against a database of 154 EGFR ligands reveal …
In the current study, a 2D similarity/docking-based study was used to predict the potential binding modes of icotinib, almonertinib, and …
Spectroscopic, molecular docking and dynamic simulation studies of binding between the new anticancer agent olmutinib and human serum albumin.
Alanazi AM, Bakheit AH, Attwa MW, Abdelhameed AS. Alanazi AM, et al. J Biomol Struct Dyn. 2022;40(24):14236-14246. doi: 10.1080/07391102.2021.2001380. Epub 2021 Nov 12. J Biomol Struct Dyn. 2022. PMID: 34766879
In this study, the interaction between human serum albumin (HSA), which is the key bio-distributor of exogenous and endogenous compounds in the human bloodstream, and HM61713 (Olmutinib; OMB), which is used as an anticancer drug, is examined by multiple spectroscopic techn …
In this study, the interaction between human serum albumin (HSA), which is the key bio-distributor of exogenous and endogenous compounds in …
41 results