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Page 1
Estrogenic activity of isoflavonoids from Onobrychis ebenoides.
Halabalaki M, Alexi X, Aligiannis N, Lambrinidis G, Pratsinis H, Florentin I, Mitakou S, Mikros E, Skaltsounis AL, Alexis MN. Halabalaki M, et al. Planta Med. 2006 May;72(6):488-93. doi: 10.1055/s-2005-916261. Planta Med. 2006. PMID: 16773531
Fractionation of the neutral extract of Onobrychis ebenoides (Leguminosae) yielded a new isoflavone, named ebenosin (1), in addition to the known ones, afrormosin (2), formononetin (3) and daidzein (4). ...
Fractionation of the neutral extract of Onobrychis ebenoides (Leguminosae) yielded a new isoflavone, named ebenosin (1), in ad …
Ebenfurans IV-VIII from Onobrychis ebenoides: evidence that C-prenylation is the key determinant of the cytotoxicity of 3-formyl-2-arylbenzofurans.
Halabalaki M, Alexi X, Aligiannis N, Alexis MN, Skaltsounis AL. Halabalaki M, et al. J Nat Prod. 2008 Nov;71(11):1934-7. doi: 10.1021/np800134h. Epub 2008 Nov 6. J Nat Prod. 2008. PMID: 18986200
Phytochemical investigation of a methanol extract of Onobrychis ebenoides yielded five new 3-formyl-2-arylbenzofurans, namely, ebenfurans IV-VIII (1-5), together with the known compounds ebenfurans I, II (6), and III (7). ...
Phytochemical investigation of a methanol extract of Onobrychis ebenoides yielded five new 3-formyl-2-arylbenzofurans, namely, …
Protective effect of plant extract from Onobrychis ebenoides on ovariectomy-induced bone loss in rats.
Dontas I, Halabalaki M, Moutsatsou P, Mitakou S, Papoutsi Z, Khaldi L, Galanos A, Lyritis GP. Dontas I, et al. Maturitas. 2006 Jan 20;53(2):234-42. doi: 10.1016/j.maturitas.2005.05.007. Epub 2005 Jun 23. Maturitas. 2006. PMID: 15979258
The present study was undertaken to investigate the possible protective effect of the aqueous solution of the plant Onobrychis ebenoides, with proven in vitro mild estrogenic action, on bone mass loss of the ovariectomized (Ovx) rat experimental model of osteoporosi …
The present study was undertaken to investigate the possible protective effect of the aqueous solution of the plant Onobrychis ebe …
Three new arylobenzofurans from Onobrychis ebenoides and evaluation of their binding affinity for the estrogen receptor.
Halabalaki M, Aligiannis N, Papoutsi Z, Mitakou S, Moutsatsou P, Sekeris C, Skaltsounis AL. Halabalaki M, et al. J Nat Prod. 2000 Dec;63(12):1672-4. doi: 10.1021/np000071b. J Nat Prod. 2000. PMID: 11141112
Three new 2-phenyl-benzofurans, ebenfuran I, ebenfuran II, and ebenfuran III, were isolated from Onobrychis ebenoides. Their structures were elucidated on the basis of chemical and spectral data as 2-(2,4-dihydroxyphenyl)-5-hydroxy-6-methoxy-benzofuran (1), 2-(2,4-d …
Three new 2-phenyl-benzofurans, ebenfuran I, ebenfuran II, and ebenfuran III, were isolated from Onobrychis ebenoides. Their s …
Evaluation of estrogenic/antiestrogenic activity of Onobrychis ebenoides extract - interaction with estrogen receptor subtypes ERalpha and ERbeta.
Papoutsi Z, Kassi E, Halabalaki M, Mitakou S, Moutsatsou P. Papoutsi Z, et al. Toxicol In Vitro. 2007 Apr;21(3):364-70. doi: 10.1016/j.tiv.2006.09.009. Epub 2006 Sep 29. Toxicol In Vitro. 2007. PMID: 17092687
A protective effect of plant extract from Onobrychis ebenoides on ovariectomy-induced bone loss in rats has been shown. To investigate the molecular mechanisms that underly the beneficial effect of O. ebenoides (Onb) on bone loss, we studied its potential to …
A protective effect of plant extract from Onobrychis ebenoides on ovariectomy-induced bone loss in rats has been shown. To inv …
Plant 2-arylobenzofurans demonstrate a selective estrogen receptor modulator profile.
Papoutsi Z, Kassi E, Papaevangeliou D, Pratsinis H, Zoumpourlis V, Halabalaki M, Mitakou S, Kalofoutis A, Moutsatsou P. Papoutsi Z, et al. Steroids. 2004 Oct-Nov;69(11-12):727-34. doi: 10.1016/j.steroids.2004.07.005. Steroids. 2004. PMID: 15579325
We have isolated from the plant Onobrychis ebenoides three novel arylobenzofurans with binding affinity for the estrogen receptor. ...
We have isolated from the plant Onobrychis ebenoides three novel arylobenzofurans with binding affinity for the estrogen recep …
Pharmacoproteomic study of the natural product Ebenfuran III in DU-145 prostate cancer cells: the quantitative and temporal interrogation of chemically induced cell death at the protein level.
Roumeliotis TI, Halabalaki M, Alexi X, Ankrett D, Giannopoulou EG, Skaltsounis AL, Sayan BS, Alexis MN, Townsend PA, Garbis SD. Roumeliotis TI, et al. J Proteome Res. 2013 Apr 5;12(4):1591-603. doi: 10.1021/pr300968q. Epub 2013 Mar 12. J Proteome Res. 2013. PMID: 23418717
A naturally occurring benzofuran derivative, Ebenfuran III (Eb III), was investigated for its antiproliferative effects using the DU-145 prostate cell line. Eb III was isolated from Onobrychis ebenoides of the Leguminosae family, a plant endemic in Central and South …
A naturally occurring benzofuran derivative, Ebenfuran III (Eb III), was investigated for its antiproliferative effects using the DU-145 pro …
Cytotoxic effects of 2-arylbenzofuran phytoestrogens on human cancer cells: modulation by adrenal and gonadal steroids.
Katsanou ES, Halabalaki M, Aligiannis N, Mitakou S, Skaltsounis AL, Alexi X, Pratsinis H, Alexis MN. Katsanou ES, et al. J Steroid Biochem Mol Biol. 2007 May;104(3-5):228-36. doi: 10.1016/j.jsbmb.2007.03.028. Epub 2007 Mar 24. J Steroid Biochem Mol Biol. 2007. PMID: 17451940
We have previously reported on the isolation and the estrogen receptor (ER) modulation properties of three new 2-arylbenzofurans from Onobrychis ebenoides, ebenfuran I [2-(2,4-dihydroxyphenyl)-5-hydroxy-6-methoxy-benzofuran], ebenfuran II [2-(2,4-dihydroxyphenyl)-3- …
We have previously reported on the isolation and the estrogen receptor (ER) modulation properties of three new 2-arylbenzofurans from Ono …