Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1993 1
1998 3
1999 1
2000 3
2001 3
2002 3
2003 6
2004 4
2005 6
2006 5
2007 6
2008 4
2009 5
2010 1
2011 11
2012 7
2013 8
2014 10
2015 8
2016 7
2017 6
2018 7
2019 5
2020 6
2021 9
2022 6
2023 4
2024 1

Text availability

Article attribute

Article type

Publication date

Search Results

126 results

Results by year

Filters applied: . Clear all
Page 1
Androgen deprivation-induced OPHN1 amplification promotes castration-resistant prostate cancer.
Liu J, Zhang Y, Li S, Sun F, Wang G, Wei D, Yang T, Gu S. Liu J, et al. Oncol Rep. 2022 Jan;47(1):3. doi: 10.3892/or.2021.8214. Epub 2021 Nov 5. Oncol Rep. 2022. PMID: 34738630 Free PMC article.
Thus, the role of OPHN1 in PCa pathology was investigated. The expression status of OPHN1 in PCa was searched in The Cancer Genome Atlas (TCGA) database. ...In TCGA database, amplification of the OPHN1 gene was observed in the PCa tumors. ADT increased the ex …
Thus, the role of OPHN1 in PCa pathology was investigated. The expression status of OPHN1 in PCa was searched in The Cancer Ge …
Circ-OPHN1 suppresses the proliferation, migration, and invasion of trophoblast cells through mediating miR-558/THBS2 axis.
Li Y, Chen J, Song S. Li Y, et al. Drug Dev Res. 2022 Jun;83(4):1034-1046. doi: 10.1002/ddr.21931. Epub 2022 Mar 11. Drug Dev Res. 2022. PMID: 35277867
Circ-OPHN1 and THBS2 levels were enhanced, while miR-558 level was declined in PE placental tissues. Circ-OPHN1 or THBS2 overexpression hindered the proliferation, migration, and invasion of trophoblast cells. ...
Circ-OPHN1 and THBS2 levels were enhanced, while miR-558 level was declined in PE placental tissues. Circ-OPHN1 or THBS2 overe …
Hereditary Ataxia Overview.
Perlman S. Perlman S. 1998 Oct 28 [updated 2023 Nov 16]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2024. 1998 Oct 28 [updated 2023 Nov 16]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2024. PMID: 20301317 Free Books & Documents. Review.
Ophn1 regulation of prefrontal inhibition: A mechanism for stress susceptibility in intellectual disability.
Cvetkovska V, Bagot RC. Cvetkovska V, et al. Neuron. 2021 May 19;109(10):1583-1584. doi: 10.1016/j.neuron.2021.04.030. Neuron. 2021. PMID: 34015262 Free article.
Wang et al. (2021) characterize the molecular, cellular, and circuit-level role of Oligophrenin-1 in prefrontal parvalbumin interneurons, demonstrating that loss of Ophn1 function in these neurons is a mechanism for increased susceptibility to stress in intellectual disabi …
Wang et al. (2021) characterize the molecular, cellular, and circuit-level role of Oligophrenin-1 in prefrontal parvalbumin interneurons, de …
Targeting the Lnc-OPHN1-5/androgen receptor/hnRNPA1 complex increases Enzalutamide sensitivity to better suppress prostate cancer progression.
Zhang M, Sun Y, Huang CP, Luo J, Zhang L, Meng J, Liang C, Chang C. Zhang M, et al. Cell Death Dis. 2021 Sep 20;12(10):855. doi: 10.1038/s41419-021-03966-4. Cell Death Dis. 2021. PMID: 34545067 Free PMC article.
Mechanism dissection revealed that lnc-OPHN1-5 interacted with AR-mRNA to minimize its interaction with the RNA binding protein (RBP) hnRNPA1. ...This effect was reversed by increasing lnc-OPHN1-5 expression. Consistently, the in vivo mice model confirmed that knock …
Mechanism dissection revealed that lnc-OPHN1-5 interacted with AR-mRNA to minimize its interaction with the RNA binding protein (RBP) …
Expanding the phenotypic spectrum associated with OPHN1 mutations: Report of 17 individuals with intellectual disability but no cerebellar hypoplasia.
Moortgat S, Lederer D, Deprez M, Buzatu M, Clapuyt P, Boulanger S, Benoit V, Mary S, Guichet A, Ziegler A, Colin E, Bonneau D, Maystadt I. Moortgat S, et al. Eur J Med Genet. 2018 Aug;61(8):442-450. doi: 10.1016/j.ejmg.2018.03.002. Epub 2018 Mar 3. Eur J Med Genet. 2018. PMID: 29510240 Review.
Among the identified OPHN1 mutations, we report for the first time a missense mutation occurring in a mosaic state. ...We emphasize the power of next generation techniques (X-exome sequencing, whole-exome sequencing and targeted multi-gene panel) to expand the phenotypic a …
Among the identified OPHN1 mutations, we report for the first time a missense mutation occurring in a mosaic state. ...We emphasize t …
Oligophrenin 1 (OPHN1) gene mutation causes syndromic X-linked mental retardation with epilepsy, rostral ventricular enlargement and cerebellar hypoplasia.
Bergmann C, Zerres K, Senderek J, Rudnik-Schoneborn S, Eggermann T, Häusler M, Mull M, Ramaekers VT. Bergmann C, et al. Brain. 2003 Jul;126(Pt 7):1537-44. doi: 10.1093/brain/awg173. Epub 2003 May 21. Brain. 2003. PMID: 12805098 Review.
Notably, OPHN1 mutations have been previously reported as a rare cause of non-syndromic X-linked mental retardation. Our findings, however, indicate that OPHN1 mutations result in a recognizable syndrome. In addition, identification of OPHN1 as a further gene …
Notably, OPHN1 mutations have been previously reported as a rare cause of non-syndromic X-linked mental retardation. Our findings, ho …
Oligophrenin-1 (Ophn1) is expressed in mouse retinal vessels.
Sel S, Kaiser M, Nass N, Trau S, Roepke A, Storsberg J, Hampel U, Paulsen F, Kalinski T. Sel S, et al. Gene Expr Patterns. 2012 Jan-Feb;12(1-2):63-7. doi: 10.1016/j.gep.2011.11.003. Epub 2011 Nov 20. Gene Expr Patterns. 2012. PMID: 22119667
In the present study we investigated the spatial and temporal expression of Ophn1 in the mouse eye. The expression of Ophn1 was analysed on both mRNA and protein level. ...Ophn1 transcripts were detected in adult retina by RT-PCR and confirmed by sequencing. …
In the present study we investigated the spatial and temporal expression of Ophn1 in the mouse eye. The expression of Ophn1 wa …
Novel unconventional variants expand the allelic spectrum of OPHN1 gene.
Nuovo S, Brankovic V, Caputi C, Casella A, Nigro V, Leuzzi V, Valente EM. Nuovo S, et al. Am J Med Genet A. 2021 May;185(5):1575-1581. doi: 10.1002/ajmg.a.62144. Epub 2021 Feb 27. Am J Med Genet A. 2021. PMID: 33638601
Mutations in the OPHN1 gene cause a rare X-linked recessive neurodevelopmental disorder characterized by intellectual disability, variably associated with cerebellar hypoplasia and distinctive facial appearance. ...Clinical and neuroimaging findings in the patients recapit …
Mutations in the OPHN1 gene cause a rare X-linked recessive neurodevelopmental disorder characterized by intellectual disability, var …
Oligophrenin-1 (OPHN1), a gene involved in X-linked intellectual disability, undergoes RNA editing and alternative splicing during human brain development.
Barresi S, Tomaselli S, Athanasiadis A, Galeano F, Locatelli F, Bertini E, Zanni G, Gallo A. Barresi S, et al. PLoS One. 2014 Mar 17;9(3):e91351. doi: 10.1371/journal.pone.0091351. eCollection 2014. PLoS One. 2014. PMID: 24637888 Free PMC article.
Oligophrenin-1 (OPHN1) encodes for a Rho-GTPase-activating protein, important for dendritic morphogenesis and synaptic function. ...We found that OPHN1 editing is detectable already at the 18th week of gestation in human brain with a boost of editing at weeks 20 to …
Oligophrenin-1 (OPHN1) encodes for a Rho-GTPase-activating protein, important for dendritic morphogenesis and synaptic function. ...W …
126 results