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Photochemical activation of TRPA1 channels in neurons and animals.
Kokel D, Cheung CY, Mills R, Coutinho-Budd J, Huang L, Setola V, Sprague J, Jin S, Jin YN, Huang XP, Bruni G, Woolf CJ, Roth BL, Hamblin MR, Zylka MJ, Milan DJ, Peterson RT. Kokel D, et al. Nat Chem Biol. 2013 Apr;9(4):257-63. doi: 10.1038/nchembio.1183. Epub 2013 Feb 10. Nat Chem Biol. 2013. PMID: 23396078 Free PMC article.
TRPA1 is both necessary and sufficient for the optovin response. Optovin activates human TRPA1 via structure-dependent photochemical reactions with redox-sensitive cysteine residues. In animals with severed spinal cords, optovin treatment enables control of m …
TRPA1 is both necessary and sufficient for the optovin response. Optovin activates human TRPA1 via structure-dependent photoch …
A high-conductance chemo-optogenetic system based on the vertebrate channel Trpa1b.
Lam PY, Mendu SK, Mills RW, Zheng B, Padilla H, Milan DJ, Desai BN, Peterson RT. Lam PY, et al. Sci Rep. 2017 Sep 19;7(1):11839. doi: 10.1038/s41598-017-11791-z. Sci Rep. 2017. PMID: 28928472 Free PMC article.
Here, we expand the optogenetics toolbox in the form of a tunable, high-conductance vertebrate cation channel, zTrpa1b, coupled with photo-activated channel ligands, such as optovin and 4g6. Our results demonstrate that zTrpa1b/ligand pairing offers high light sensitivity, …
Here, we expand the optogenetics toolbox in the form of a tunable, high-conductance vertebrate cation channel, zTrpa1b, coupled with photo-a …
TRPA1 expression and its functional activation in rodent cortex.
Kheradpezhouh E, Choy JMC, Daria VR, Arabzadeh E. Kheradpezhouh E, et al. Open Biol. 2017 Apr;7(4):160314. doi: 10.1098/rsob.160314. Open Biol. 2017. PMID: 28424320 Free PMC article.
These modulations were absent in the TRPA1 knockout mice. Next, we used optovin, a reversible photoactive molecule, to activate TRPA1 in individual L5 neurons of rat cortex. Optical control of activity was established by applying a tightly focused femtosecond-pulsed laser …
These modulations were absent in the TRPA1 knockout mice. Next, we used optovin, a reversible photoactive molecule, to activate TRPA1 …
Transient Receptor Potential Ankyrin 1 Activation within the Cardiac Myocyte Limits Ischemia-reperfusion Injury in Rodents.
Lu Y, Piplani H, McAllister SL, Hurt CM, Gross ER. Lu Y, et al. Anesthesiology. 2016 Dec;125(6):1171-1180. doi: 10.1097/ALN.0000000000001377. Anesthesiology. 2016. PMID: 27748654 Free PMC article.

Further, using a rat in vivo model of cardiac injury, the TRPA1 activators ASP 7663 and optovin reduce myocardial injury (45 5%* and 44 8%,* respectively, vs. control, 66 6% infarct size/area at risk; n = 6 per group; mean SD; *P < 0.001). ...In isolated cardiac myocyte

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Further, using a rat in vivo model of cardiac injury, the TRPA1 activators ASP 7663 and optovin reduce myocardial injury (45 5%* and …