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CD44, a therapeutic target for metastasising tumours.
Orian-Rousseau V. Orian-Rousseau V. Eur J Cancer. 2010 May;46(7):1271-7. doi: 10.1016/j.ejca.2010.02.024. Epub 2010 Mar 19. Eur J Cancer. 2010. PMID: 20303742 Review.
CD44: More than a mere stem cell marker.
Morath I, Hartmann TN, Orian-Rousseau V. Morath I, et al. Int J Biochem Cell Biol. 2016 Dec;81(Pt A):166-173. doi: 10.1016/j.biocel.2016.09.009. Epub 2016 Sep 15. Int J Biochem Cell Biol. 2016. PMID: 27640754 Review.
Perspectives of CD44 targeting therapies.
Orian-Rousseau V, Ponta H. Orian-Rousseau V, et al. Arch Toxicol. 2015 Jan;89(1):3-14. doi: 10.1007/s00204-014-1424-2. Epub 2014 Dec 5. Arch Toxicol. 2015. PMID: 25472903 Review.
CD44 functions in Wnt signaling by regulating LRP6 localization and activation.
Schmitt M, Metzger M, Gradl D, Davidson G, Orian-Rousseau V. Schmitt M, et al. Cell Death Differ. 2015 Apr;22(4):677-89. doi: 10.1038/cdd.2014.156. Epub 2014 Oct 10. Cell Death Differ. 2015. PMID: 25301071 Free PMC article.
Opposing effects of high- and low-molecular weight hyaluronan on CXCL12-induced CXCR4 signaling depend on CD44.
Fuchs K, Hippe A, Schmaus A, Homey B, Sleeman JP, Orian-Rousseau V. Fuchs K, et al. Cell Death Dis. 2013 Oct 3;4(10):e819. doi: 10.1038/cddis.2013.364. Cell Death Dis. 2013. PMID: 24091662 Free PMC article.
CD44 acts both as a growth- and invasiveness-promoting molecule and as a tumor-suppressing cofactor.
Herrlich P, Morrison H, Sleeman J, Orian-Rousseau V, König H, Weg-Remers S, Ponta H. Herrlich P, et al. Ann N Y Acad Sci. 2000 Jun;910:106-18; discussion 118-20. doi: 10.1111/j.1749-6632.2000.tb06704.x. Ann N Y Acad Sci. 2000. PMID: 10911909 Review.
Involvement of CD44v6 in InlB-dependent Listeria invasion.
Jung C, Matzke A, Niemann HH, Schwerk C, Tenenbaum T, Orian-Rousseau V. Jung C, et al. Mol Microbiol. 2009 Jun;72(5):1196-207. doi: 10.1111/j.1365-2958.2009.06716.x. Epub 2009 Apr 30. Mol Microbiol. 2009. PMID: 19432801
Epidermal-specific deletion of CD44 reveals a function in keratinocytes in response to mechanical stress.
Shatirishvili M, Burk AS, Franz CM, Pace G, Kastilan T, Breuhahn K, Hinterseer E, Dierich A, Bakiri L, Wagner EF, Ponta H, Hartmann TN, Tanaka M, Orian-Rousseau V. Shatirishvili M, et al. Cell Death Dis. 2016 Nov 10;7(11):e2461. doi: 10.1038/cddis.2016.342. Cell Death Dis. 2016. PMID: 27831556 Free PMC article.
CD44 regulates Wnt signaling at the level of LRP6.
Orian-Rousseau V, Schmitt M. Orian-Rousseau V, et al. Mol Cell Oncol. 2015 Jan 23;2(3):e995046. doi: 10.4161/23723556.2014.995046. eCollection 2015 Jul-Sep. Mol Cell Oncol. 2015. PMID: 27308483 Free PMC article.
Direct binding of hepatocyte growth factor and vascular endothelial growth factor to CD44v6.
Volz Y, Koschut D, Matzke-Ogi A, Dietz MS, Karathanasis C, Richert L, Wagner MG, Mély Y, Heilemann M, Niemann HH, Orian-Rousseau V. Volz Y, et al. Biosci Rep. 2015 Jun 29;35(4):e00236. doi: 10.1042/BSR20150093. Biosci Rep. 2015. PMID: 26181364 Free PMC article.
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