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NCX-1000, a nitric oxide-releasing derivative of ursodeoxycholic acid, ameliorates portal hypertension and lowers norepinephrine-induced intrahepatic resistance in the isolated and perfused rat liver.
Fiorucci S, Antonelli E, Brancaleone V, Sanpaolo L, Orlandi S, Distrutti E, Acuto G, Clerici C, Baldoni M, Del Soldato P, Morelli A. Fiorucci S, et al. Among authors: orlandi s. J Hepatol. 2003 Dec;39(6):932-9. doi: 10.1016/s0168-8278(03)00393-3. J Hepatol. 2003. PMID: 14642608
5-Amino-2-hydroxybenzoic acid 4-(5-thioxo-5H-[1,2]dithiol-3yl)-phenyl ester (ATB-429), a hydrogen sulfide-releasing derivative of mesalamine, exerts antinociceptive effects in a model of postinflammatory hypersensitivity.
Distrutti E, Sediari L, Mencarelli A, Renga B, Orlandi S, Russo G, Caliendo G, Santagada V, Cirino G, Wallace JL, Fiorucci S. Distrutti E, et al. Among authors: orlandi s. J Pharmacol Exp Ther. 2006 Oct;319(1):447-58. doi: 10.1124/jpet.106.106435. Epub 2006 Jul 19. J Pharmacol Exp Ther. 2006. PMID: 16855178 Free article.
A farnesoid x receptor-small heterodimer partner regulatory cascade modulates tissue metalloproteinase inhibitor-1 and matrix metalloprotease expression in hepatic stellate cells and promotes resolution of liver fibrosis.
Fiorucci S, Rizzo G, Antonelli E, Renga B, Mencarelli A, Riccardi L, Orlandi S, Pruzanski M, Morelli A, Pellicciari R. Fiorucci S, et al. Among authors: orlandi s. J Pharmacol Exp Ther. 2005 Aug;314(2):584-95. doi: 10.1124/jpet.105.084905. Epub 2005 Apr 28. J Pharmacol Exp Ther. 2005. PMID: 15860571
3alpha-6alpha-Dihydroxy-7alpha-fluoro-5beta-cholanoate (UPF-680), physicochemical and physiological properties of a new fluorinated bile acid that prevents 17alpha-ethynyl-estradiol-induced cholestasis in rats.
Clerici C, Castellani D, Asciutti S, Pellicciari R, Setchell KD, O'Connell NC, Sadeghpour B, Camaioni E, Fiorucci S, Renga B, Nardi E, Sabatino G, Clementi M, Giuliano V, Baldoni M, Orlandi S, Mazzocchi A, Morelli A, Morelli O. Clerici C, et al. Among authors: orlandi s. Toxicol Appl Pharmacol. 2006 Jul 15;214(2):199-208. doi: 10.1016/j.taap.2005.12.017. Epub 2006 Feb 17. Toxicol Appl Pharmacol. 2006. PMID: 16487557
156 results