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The proteasome as a target for cancer therapy.
Voorhees PM, Dees EC, O'Neil B, Orlowski RZ. Voorhees PM, et al. Among authors: orlowski rz. Clin Cancer Res. 2003 Dec 15;9(17):6316-25. Clin Cancer Res. 2003. PMID: 14695130 Review.
The proteasome and proteasome inhibitors in cancer therapy.
Voorhees PM, Orlowski RZ. Voorhees PM, et al. Among authors: orlowski rz. Annu Rev Pharmacol Toxicol. 2006;46:189-213. doi: 10.1146/annurev.pharmtox.46.120604.141300. Annu Rev Pharmacol Toxicol. 2006. PMID: 16402903 Review.
Proteasome inhibitors in the treatment of multiple myeloma.
Shah JJ, Orlowski RZ. Shah JJ, et al. Among authors: orlowski rz. Leukemia. 2009 Nov;23(11):1964-79. doi: 10.1038/leu.2009.173. Epub 2009 Sep 10. Leukemia. 2009. PMID: 19741722 Free PMC article. Review.
Rapid early monoclonal protein reduction after therapy with bortezomib or bortezomib and pegylated liposomal doxorubicin in relapsed/refractory myeloma is associated with a longer time to progression.
Shah J, Bladé J, Sonneveld P, Harousseau JL, Lantz K, Londhe A, Lowery C, Orlowski RZ. Shah J, et al. Among authors: orlowski rz. Cancer. 2011 Aug 15;117(16):3758-62. doi: 10.1002/cncr.25937. Epub 2011 Feb 15. Cancer. 2011. PMID: 21328327 Free PMC article. Clinical Trial.
A small molecule inhibitor of ubiquitin-specific protease-7 induces apoptosis in multiple myeloma cells and overcomes bortezomib resistance.
Chauhan D, Tian Z, Nicholson B, Kumar KG, Zhou B, Carrasco R, McDermott JL, Leach CA, Fulcinniti M, Kodrasov MP, Weinstock J, Kingsbury WD, Hideshima T, Shah PK, Minvielle S, Altun M, Kessler BM, Orlowski R, Richardson P, Munshi N, Anderson KC. Chauhan D, et al. Cancer Cell. 2012 Sep 11;22(3):345-58. doi: 10.1016/j.ccr.2012.08.007. Cancer Cell. 2012. PMID: 22975377 Free PMC article.
352 results