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Pattern recognition receptors in fungal immunity.
Patin EC, Thompson A, Orr SJ. Patin EC, et al. Semin Cell Dev Biol. 2019 May;89:24-33. doi: 10.1016/j.semcdb.2018.03.003. Epub 2018 Mar 9. Semin Cell Dev Biol. 2019. PMID: 29522806 Free PMC article. Review.
The protective effect of inflammatory monocytes during systemic C. albicans infection is dependent on collaboration between C-type lectin-like receptors.
Thompson A, Davies LC, Liao CT, da Fonseca DM, Griffiths JS, Andrews R, Jones AV, Clement M, Brown GD, Humphreys IR, Taylor PR, Orr SJ. Thompson A, et al. Among authors: orr sj. PLoS Pathog. 2019 Jun 26;15(6):e1007850. doi: 10.1371/journal.ppat.1007850. eCollection 2019 Jun. PLoS Pathog. 2019. PMID: 31242262 Free PMC article.
Dependence on Dectin-1 Varies With Multiple Candida Species.
Thompson A, Griffiths JS, Walker L, da Fonseca DM, Lee KK, Taylor PR, Gow NAR, Orr SJ. Thompson A, et al. Among authors: orr sj. Front Microbiol. 2019 Aug 6;10:1800. doi: 10.3389/fmicb.2019.01800. eCollection 2019. Front Microbiol. 2019. PMID: 31447813 Free PMC article.
Differential susceptibility of Dectin-1 isoforms to functional inactivation by neutrophil and fungal proteases.
Griffiths JS, Thompson A, Stott M, Benny A, Lewis NA, Taylor PR, Forton J, Herrick S, Orr SJ, McGreal EP. Griffiths JS, et al. Among authors: orr sj. FASEB J. 2018 Jun;32(6):3385-3397. doi: 10.1096/fj.201701145R. Epub 2018 Jan 22. FASEB J. 2018. PMID: 29401615 Free PMC article.
Thus, Dectin-1 and Dectin-2 cleavage by NE and/or A. fumigatus-derived proteases results in an aberrant antifungal immune response that likely contributes to disease pathology in patients with CF.-Griffiths, J. S., Thompson, A., Stott, M., Benny, A., Lewis, N. A., Taylor, …
Thus, Dectin-1 and Dectin-2 cleavage by NE and/or A. fumigatus-derived proteases results in an aberrant antifungal immune response that like …
IL-33 Augments Virus-Specific Memory T Cell Inflation and Potentiates the Efficacy of an Attenuated Cytomegalovirus-Based Vaccine.
McLaren JE, Clement M, Marsden M, Miners KL, Llewellyn-Lacey S, Grant EJ, Rubina A, Gimeno Brias S, Gostick E, Stacey MA, Orr SJ, Stanton RJ, Ladell K, Price DA, Humphreys IR. McLaren JE, et al. Among authors: orr sj. J Immunol. 2019 Feb 1;202(3):943-955. doi: 10.4049/jimmunol.1701757. J Immunol. 2019. PMID: 30635396 Free PMC article.
626 results