Osheroff N - Search Results

1

Target-Mediated Fluoroquinolone Resistance in Neisseria gonorrhoeae: Actions of Ciprofloxacin against Gyrase and Topoisomerase IV.

Collins JA, Oviatt AA, Chan PF, Osheroff N. Collins JA, et al. Among authors: osheroff n. ACS Infect Dis. 2024 Apr 12;10(4):1351-1360. doi: 10.1021/acsinfecdis.4c00041. Epub 2024 Mar 4. ACS Infect Dis. 2024. PMID: 38606464 Free PMC article.

2

Mechanistic and Structural Basis for the Actions of the Antibacterial Gepotidacin against Staphylococcus aureus Gyrase.

Gibson EG, Bax B, Chan PF, Osheroff N. Gibson EG, et al. Among authors: osheroff n. ACS Infect Dis. 2019 Apr 12;5(4):570-581. doi: 10.1021/acsinfecdis.8b00315. Epub 2019 Feb 28. ACS Infect Dis. 2019. PMID: 30757898 Free PMC article.

3

Bimodal Actions of a Naphthyridone/Aminopiperidine-Based Antibacterial That Targets Gyrase and Topoisomerase IV.

Gibson EG, Oviatt AA, Cacho M, Neuman KC, Chan PF, Osheroff N. Gibson EG, et al. Among authors: osheroff n. Biochemistry. 2019 Nov 5;58(44):4447-4455. doi: 10.1021/acs.biochem.9b00805. Epub 2019 Oct 28. Biochemistry. 2019. PMID: 31617352 Free PMC article.

4

Gyrase and Topoisomerase IV: Recycling Old Targets for New Antibacterials to Combat Fluoroquinolone Resistance.

Collins JA, Osheroff N. Collins JA, et al. Among authors: osheroff n. ACS Infect Dis. 2024 Apr 12;10(4):1097-1115. doi: 10.1021/acsinfecdis.4c00128. Epub 2024 Apr 2. ACS Infect Dis. 2024. PMID: 38564341 Free PMC article. Review.

5

Interactions between Gepotidacin and Escherichia coli Gyrase and Topoisomerase IV: Genetic and Biochemical Evidence for Well-Balanced Dual-Targeting.

Oviatt AA, Gibson EG, Huang J, Mattern K, Neuman KC, Chan PF, Osheroff N. Oviatt AA, et al. Among authors: osheroff n. ACS Infect Dis. 2024 Apr 12;10(4):1137-1151. doi: 10.1021/acsinfecdis.3c00346. Epub 2024 Mar 5. ACS Infect Dis. 2024. PMID: 38606465 Free PMC article.

6

Polyamine-containing etoposide derivatives as poisons of human type II topoisomerases: Differential effects on topoisomerase IIα and IIβ.

Oviatt AA, Kuriappan JA, Minniti E, Vann KR, Onuorah P, Minarini A, De Vivo M, Osheroff N. Oviatt AA, et al. Among authors: osheroff n. Bioorg Med Chem Lett. 2018 Sep 15;28(17):2961-2968. doi: 10.1016/j.bmcl.2018.07.010. Epub 2018 Jul 5. Bioorg Med Chem Lett. 2018. PMID: 30006062 Free PMC article.

7

1,2-Naphthoquinone as a Poison of Human Type II Topoisomerases.

Collins JA, Osheroff N. Collins JA, et al. Among authors: osheroff n. Chem Res Toxicol. 2021 Apr 19;34(4):1082-1090. doi: 10.1021/acs.chemrestox.0c00492. Epub 2021 Mar 24. Chem Res Toxicol. 2021. PMID: 33760604 Free PMC article.

8

Topoisomerase II Poisons: Converting Essential Enzymes into Molecular Scissors.

Vann KR, Oviatt AA, Osheroff N. Vann KR, et al. Among authors: osheroff n. Biochemistry. 2021 Jun 1;60(21):1630-1641. doi: 10.1021/acs.biochem.1c00240. Epub 2021 May 19. Biochemistry. 2021. PMID: 34008964 Free PMC article. Review.

9

1,3-Dioxane-Linked Novel Bacterial Topoisomerase Inhibitors: Expanding Structural Diversity and the Antibacterial Spectrum.

Lu Y, Mann CA, Nolan S, Collins JA, Parker E, Papa J, Vibhute S, Jahanbakhsh S, Thwaites M, Hufnagel D, Hazbón MH, Moreno J, Stedman TT, Wittum T, Wozniak DJ, Osheroff N, Yalowich JC, Mitton-Fry MJ. Lu Y, et al. Among authors: osheroff n. ACS Med Chem Lett. 2022 May 9;13(6):955-963. doi: 10.1021/acsmedchemlett.2c00111. eCollection 2022 Jun 9. ACS Med Chem Lett. 2022. PMID: 35707162 Free PMC article.

10

Actions of a Novel Bacterial Topoisomerase Inhibitor against Neisseria gonorrhoeae Gyrase and Topoisomerase IV: Enhancement of Double-Stranded DNA Breaks.

Dauda SE, Collins JA, Byl JAW, Lu Y, Yalowich JC, Mitton-Fry MJ, Osheroff N. Dauda SE, et al. Among authors: osheroff n. Int J Mol Sci. 2023 Jul 28;24(15):12107. doi: 10.3390/ijms241512107. Int J Mol Sci. 2023. PMID: 37569485 Free PMC article.

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