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Irinophore C™, a lipid nanoparticle formulation of irinotecan, abrogates the gastrointestinal effects of irinotecan in a rat model of clinical toxicities.
Waterhouse DN, Sutherland BW, Santos ND, Masin D, Osooly M, Strutt D, Ostlund C, Anantha M, Harasym N, Manisali I, Wehbe M, Bally MB, Webb MS. Waterhouse DN, et al. Among authors: osooly m. Invest New Drugs. 2014 Dec;32(6):1071-82. doi: 10.1007/s10637-014-0138-x. Epub 2014 Jul 27. Invest New Drugs. 2014. PMID: 25064374 Free PMC article.
Validating the use of a luciferase labeled breast cancer cell line, MDA435LCC6, as a means to monitor tumor progression and to assess the therapeutic activity of an established anticancer drug, docetaxel (Dt) alone or in combination with the ILK inhibitor, QLT0267.
Kalra J, Anantha M, Warburton C, Waterhouse D, Yan H, Yang YJ, Strut D, Osooly M, Masin D, Bally MB. Kalra J, et al. Among authors: osooly m. Cancer Biol Ther. 2011 May 1;11(9):826-38. doi: 10.4161/cbt.11.9.15183. Epub 2011 May 1. Cancer Biol Ther. 2011. PMID: 21358264 Free PMC article.
Loss of Parkinson's susceptibility gene LRRK2 promotes carcinogen-induced lung tumorigenesis.
Lebovitz C, Wretham N, Osooly M, Milne K, Dash T, Thornton S, Tessier-Cloutier B, Sathiyaseelan P, Bortnik S, Go NE, Halvorsen E, Cederberg RA, Chow N, Dos Santos N, Bennewith KL, Nelson BH, Bally MB, Lam WL, Gorski SM. Lebovitz C, et al. Among authors: osooly m. Sci Rep. 2021 Jan 22;11(1):2097. doi: 10.1038/s41598-021-81639-0. Sci Rep. 2021. PMID: 33483550 Free PMC article.
[213Bi]Bi3+/[111In]In3+-neunpa-cycMSH: Theranostic Radiopharmaceutical Targeting Melanoma─Structural, Radiochemical, and Biological Evaluation.
Wharton L, Zhang C, Yang H, Zeisler J, Radchenko V, Rodríguez-Rodríguez C, Osooly M, Patrick BO, Lin KS, Bénard F, Schaffer P, Orvig C. Wharton L, et al. Among authors: osooly m. Bioconjug Chem. 2022 Mar 16;33(3):505-522. doi: 10.1021/acs.bioconjchem.2c00038. Epub 2022 Mar 3. Bioconjug Chem. 2022. PMID: 35239331
H4picoopa─Robust Chelate for 225Ac/111In Theranostics.
Wharton L, Jaraquemada-Peláez MG, Zhang C, Zeisler J, Rodríguez-Rodríguez C, Osooly M, Radchenko V, Yang H, Lin KS, Bénard F, Schaffer P, Orvig C. Wharton L, et al. Among authors: osooly m. Bioconjug Chem. 2022 Oct 19;33(10):1900-1921. doi: 10.1021/acs.bioconjchem.2c00364. Epub 2022 Sep 20. Bioconjug Chem. 2022. PMID: 36126334